Skip to main content
SpringerLink
Log in

Diagnostik und Therapie pulmonaler Pilzinfektionen

Auf Pilzsuche in der Lunge

  • fortbildung
  • Published:
Pneumo News Aims and scope

Die Lunge immunschwacher Patienten kann von unterschiedlichen Pilzspezies befallen werden. Für die Prognose der Betroffenen ist entscheidend, den Erreger schnell zu identifizieren und zu behandeln. Wichtig dabei ist die Unterscheidung zwischen Kolonisation und akuter Infektion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Pfaller MA, Andes DR, Diekema DJ et al. Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) registry 2004-2008. PLoS One. 2014;9(7):e101510. doi: 10.1371/journal.pone.0101510

    Article  PubMed  PubMed Central  Google Scholar 

  2. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20:133–63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Borg-von Zepelin M, Kunz L, Ruchel R et al. Epidemiology and antifungal susceptibilities of Candida spp. to six antifungal agents: results from a surveillance study on fungaemia in Germany from July 2004 to August 2005. J Antimicrob Chemother. 2007;60:424–8

    Article  CAS  PubMed  Google Scholar 

  4. Pappas PG, Kauffman CA, Andes D et al. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:503–35

    Article  CAS  PubMed  Google Scholar 

  5. Ostrosky-Zeichner L, Pappas PG. Invasive candidiasis in the intensive care unit. Crit Care Med. 2006;34:857–63

    Article  PubMed  Google Scholar 

  6. Sims CR, Ostrosky-Zeichner L, Rex JH. Invasive candidiasis in immunocompromised hospitalized patients. Arch Med Res. 2005;36:660–71

    Article  PubMed  Google Scholar 

  7. Tortorano AM, Kibbler C, Peman J et al. Candidaemia in Europe: epidemiology and resistance. Int J Antimicrob Agents. 2006;27:359–66

    Article  CAS  PubMed  Google Scholar 

  8. Tortorano AM, Peman J, Bernhardt H et al. Epidemiology of candidaemia in Europe: results of 28-month European Confederation of Medical Mycology (ECMM) hospital-based surveillance study. Eur J Clin Microbiol Infect Dis. 2004;23:317–22

    Article  CAS  PubMed  Google Scholar 

  9. Kousha M, Tadi R, Soubani AO. Pulmonary aspergillosis: a clinical review. Eur Respir Rev. 2011;20:156–74

    Article  CAS  PubMed  Google Scholar 

  10. Soubani AO, Chandrasekar PH. The clinical spectrum of pulmonary aspergillosis. Chest. 2002;121:1988–99

    Article  PubMed  Google Scholar 

  11. Wiesmuller GA, Heinzow B, Aurbach U et al. Medizinisch klinische Diagnostik bei Schimmelpilzexposition in Innenraumen. Pneumologie. 2016;70:699–741

    Article  CAS  PubMed  Google Scholar 

  12. Cuenca-Estrella M, Verweij PE, Arendrup MC et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: diagnostic procedures. Clin Microbiol Infect. 2012;8 Suppl 7:9–18

    Article  Google Scholar 

  13. Blot S, Dimopoulos G, Rello J et al. Is Candida really a threat in the ICU? Curr Opin Crit Care. 2008; 4:600–4

    Article  Google Scholar 

  14. Rello J, Esandi ME, Diaz E et al. The role of Candida sp isolated from bronchoscopic samples in nonneutropenic patients. Chest. 1998;114:146–9

    Article  CAS  PubMed  Google Scholar 

  15. Kauffman CA, Fisher JF, Sobel JD et al. Candida urinary tract infections—diagnosis. Clin Infect Dis. 2011;52 Suppl 6:452–6

    Article  Google Scholar 

  16. Fisher JF, Kavanagh K, Sobel JD et al. Candida urinary tract infection: pathogenesis. Clin Infect Dis. 2011;52 Suppl 6:437–51

    Article  Google Scholar 

  17. Sobel JD, Fisher JF, Kauffman CA et al. Candida urinary tract infections—epidemiology. Clin Infect Dis. 2011;52 Suppl 6:433–36

    Article  Google Scholar 

  18. Arvanitis M, Anagnostou T, Fuchs BB et al. Molecular and nonmolecular diagnostic methods for invasive fungal infections. Clin Microbiol Rev. 2014;27:490–526

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Maertens J, Buve K, Theunissen K et al. Galactomannan serves as a surrogate endpoint for outcome of pulmonary invasive aspergillosis in neutropenic hematology patients. Cancer. 2009;115: 355–62

    Article  PubMed  Google Scholar 

  20. Meersseman W, Lagrou K, Maertens J et al. Galactomannan in bronchoalveolar lavage fluid: a tool for diagnosing aspergillosis in intensive care unit patients. Am J Respir Crit Care Med. 2008;177:27–34

    Article  PubMed  Google Scholar 

  21. Meersseman W, Lagrou K, Maertens J et al. Invasive aspergillosis in the intensive care unit. Clin Infect Dis. 2007;45:205–16

    Article  PubMed  Google Scholar 

  22. Lichtenstern C, Swoboda S, Hirschburger M et al. Update: invasive Pilzinfektionen. Diagnose und Therapie in der operativen Intensivmedizin. Anaesthesist. 2010;59:30–52

    Article  CAS  PubMed  Google Scholar 

  23. Maymind M, Thomas JG, Abrons HL et al. Laboratory implementation of a rapid three-stain technique for detection of microorganisms from lower respiratory specimens. J Clin Lab Anal. 1996;10:104–9

    Article  CAS  PubMed  Google Scholar 

  24. Mrazek C, Lass-Florl C. Biopsy procedures for molecular tissue diagnosis of invasive fungal infections. Curr Infect Dis Rep. 2011;13:504–9

    Article  PubMed  Google Scholar 

  25. Soler N, Torres A, Ewig S et al. Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med. 1998;157:1498–505

    Article  CAS  PubMed  Google Scholar 

  26. Rodriguez-Adrian LJ, King RT, Tamayo-Derat LG et al. Retinal lesions as clues to disseminated bacterial and candidal infections: frequency, natural history, and etiology. Medicine (Baltimore). 2003;82:187–202

    Google Scholar 

  27. Ascioglu S, Rex JH, de Pauw B et al. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin Infect Dis. 2002;34:7–14

    Article  CAS  PubMed  Google Scholar 

  28. Ascioglu S, de Pauw BE, Meis JF. Prophylaxis and treatment of fungal infections associated with haematological malignancies. Int J Antimicrob Agents. 2000;15:159–68

    Article  CAS  PubMed  Google Scholar 

  29. Limper AH, Knox KS, Sarosi GA et al. An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients. Am J Respir Crit Care Med. 2011;183:96–128

    Article  CAS  PubMed  Google Scholar 

  30. Evans SE. Coping with Candida infections. Proc Am Thorac Soc 2010;7:197–203

    Article  PubMed  Google Scholar 

  31. Kalil AC, Metersky ML, Klompas M et al. Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63:575–82

    Article  PubMed  Google Scholar 

  32. Haron E, Vartivarian S, Anaissie E et al. Primary Candida pneumonia. Experience at a large cancer center and review of the literature. Medicine (Baltimore). 1993;72:137–42

    Article  CAS  Google Scholar 

  33. Limper AH. Clinical approach and management for selected fungal infections in pulmonary and critical care patients. Chest. 2014;146:1658–66

    Article  PubMed  Google Scholar 

  34. Tissot F, Agrawal S, Pagano L et al. ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients. Haematologica 2016, doi: 10.3324/haematol.2016.152900

    Google Scholar 

  35. Tarpatzi A, Avlamis A, Papaparaskevas J et al. Incidence and risk factors for central vascular catheter-related bloodstream infections in a tertiary care hospital. New Microbiol. 2012;35:429–37

    PubMed  Google Scholar 

  36. Chabi ML, Goracci A, Roche N et al. Pulmonary aspergillosis. Diagn Interv Imaging. 2015;96:435–42

    Article  CAS  PubMed  Google Scholar 

  37. Tasci S, Schafer H, Ewig S et al. Erfolgreiche Behandlung einer chronisch nekrotisierenden pulmonalen Aspergillose mit einer oralen Itraconazol-Langzeittherapie. Dtsch Med Wochenschr. 1999;124:1419–22

    Article  CAS  PubMed  Google Scholar 

  38. Denning DW, Cadranel J, Beigelman-Aubry C et al. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J. 2016;47:45–68

    Article  CAS  PubMed  Google Scholar 

  39. Patterson TF, Thompson GR, 3rd, Denning DW et al. Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63:433–42

    Article  PubMed  Google Scholar 

  40. Alanio A, Hauser PM, Lagrou K et al. ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients. J Antimicrob Chemother. 2016;71:2386–96

    Article  CAS  PubMed  Google Scholar 

  41. Maschmeyer G, Helweg-Larsen J, Pagano L et al. ECIL guidelines for treatment of Pneumocystis jirovecii pneumonia in non-HIV-infected haematology patients. J Antimicrob Chemother. 2016;71:2405–13

    Article  CAS  PubMed  Google Scholar 

  42. Wheat LJ, Kauffman CA. Histoplasmosis. Infect Dis Clin North Am. 2003;17:1–19, vii

    Article  PubMed  Google Scholar 

  43. Kauffman CA. Pulmonary Histoplasmosis. Curr Infect Dis Rep. 2001;3:279–85

    Article  PubMed  Google Scholar 

  44. Wheat J, Sarosi G, McKinsey D et al. Practice guidelines for the management of patients with histoplasmosis. Infectious Diseases Society of America. Clin Infect Dis. 2000;30:688–95

    Article  CAS  PubMed  Google Scholar 

  45. Galgiani JN, Ampel NM, Blair JE et al. Executive Summary: 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis. Clin Infect Dis. 2016;63:717–22

    Article  PubMed  Google Scholar 

  46. Galgiani JN, Ampel NM, Blair JE et al. 2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis. Clin Infect Dis. 2016;63:e112–146

    Article  PubMed  Google Scholar 

  47. Lortholary O, Petrikkos G, Akova M et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: patients with HIV infection or AIDS. Clin Microbiol Infect. 2012;18 Suppl 7:68–77

    Article  CAS  PubMed  Google Scholar 

  48. Ullmann AJ, Akova M, Herbrecht R et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: adults with haematological malignancies and after haematopoietic stem cell transplantation (HCT). Clin Microbiol Infect. 2012;18 Suppl 7:53–67

    Article  CAS  PubMed  Google Scholar 

  49. Cornely OA, Bohme A, Buchheidt D et al. Prophylaxis of invasive fungal infections in patients with hematological malignancies and solid tufortbildung mors—guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol. 2003;82 Suppl 2:S186–200

    Article  PubMed  Google Scholar 

  50. El Zakhem A, Saad H, Tayyar R et al. Controversies in Candida management. Int J Antimicrob Agents. 2015;46 Suppl 1:S43–46

    Article  CAS  PubMed  Google Scholar 

  51. Albert M, Williamson D, Muscedere J et al. Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study). Intensive Care Med. 2014;40:1313–22

    Article  CAS  PubMed  Google Scholar 

  52. Maertens J, Cesaro S, Maschmeyer G et al. ECIL guidelines for preventing Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients. J Antimicrob Chemother. 2016;71:2397–404

    Article  CAS  PubMed  Google Scholar 

  53. Tacke D, Buchheidt D, Karthaus M et al. Primary prophylaxis of invasive fungal infections in patients with haematologic malignancies. 2014 update of the recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology. Ann Hematol. 2014;93:1449–56

    Article  CAS  PubMed  Google Scholar 

  54. Fleming S, Yannakou CK, Haeusler GM et al. Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2014. Intern Med J. 2014;44:1283–97

    Article  CAS  PubMed  Google Scholar 

  55. Kruger WH, Bohlius J, Cornely OA et al. Antimicrobial prophylaxis in allogeneic bone marrow transplantation. Guidelines of the infectious diseases working party (AGIHO) of the german society of haematology and oncology. Ann Oncol. 2005;16:1381–90

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Kreiskliniken Reutlingen / Ermstalklinik Med. Klinik III Innere Medizin/Pneumologie, Stuttgarter-Str. 100, 72574, Reutlingen-Bad Urach, Deutschland

    Adrian Gillissen

  2. Universitätsklinikum Gießen, Medizinische Klinik und Poliklinik II, Klinikstraße 33, 35392, Gießen, Deutschland

    Maria Paparoupa

Authors
  1. Adrian Gillissen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Paparoupa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Adrian Gillissen.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gillissen, A., Paparoupa, M. Auf Pilzsuche in der Lunge. Pneumo News 9, 37–45 (2017). https://doi.org/10.1007/s15033-017-0668-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15033-017-0668-y

Search

Navigation