Die kardiale Resynchronisationstherapie (CRT) stellt eine Standardbehandlung der symptomatischen, therapierefraktären Herzinsuffizienz dar. Dennoch beträgt die Rate an Non-Respondern rund 30 %. Die Bildung von simultanen Erregungsfronten im linksventrikulären Myokard mittels multipolarer Stimulation (MPP) könnte bei Respondern die Effektivität der CRT verbessern oder die Zahl der Non-Responder reduzieren.
Literatur
Ponikowski P, Voors AA, Anker SD et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37(27):2129–200
Auricchio A, Prinzen FW. Non-responders to cardiac resynchronization therapy: the magnitude of the problem and the issues. Circ J. 2011;75(3):521–7
Ginks MR, Duckett SG, Kapetanakis S et al. Multi-site left ventricular pacing as a potential treatment for patients with postero-lateral scar: insights from cardiac magnetic resonance imaging and invasive haemodynamic assessment. Europace. 2012;14(3):373–9
Forleo GB, Mantica M, Di Biase L et al. Clinical and procedural outcome of patients implanted with a quadripolar left ventricular lead: early results of a prospective multicenter study. Heart Rhythm. 2012;9(11):1822–8
Sperzel J, Danschel W, Gutleben KJ et al. First prospective, multi-centre clinical experience with a novel left ventricular quadripolar lead. Europace. 2012;14(3):365–72
Mehta PA, Shetty AK, Squirrel M et al. Elimination of phrenic nerve stimulation occurring during CRT: follow-up in patients implanted with a novel quadripolar pacing lead. J Interv Card Electrophysiol. 2012;33(1):43–9
Thibault B, Dubuc M, Khairy P et al. Acute haemodynamic comparison of multisite and biventricular pacing with a quadripolar left ventricular lead. Europace. 2013;15(7):984–91
Rinaldi CA, Leclercq C, Kranig W et al. Improvement in acute contractility and hemodynamics with multipoint pacing via a left ventricular quadripolar pacing lead. J Interv Card Electrophysiol. 2014;40(1):75–80
Pappone C, Calovic Z, Vicedomini G et al. Improving cardiac resynchronization therapy response with multipoint left ventricular pacing: Twelve-month follow-up study. Heart Rhythm. 2015;12(6):1250–8
Chung ES, Leon AR, Tavazzi L et al. Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation. 2008;117(20):2608–16
Russo C, Jaubert MP, Jin Z et al. Intra- and interobserver reproducibility of left ventricular mechanical dyssynchrony assessment by real time three-dimensional echocardiography. Echocardiography. 2012;29(5):598–607
Kleijn SA, Aly MF, Knol DL et al. A meta-analysis of left ventricular dyssynchrony assessment and prediction of response to cardiac resynchronization therapy by three-dimensional echocardiography. Eur Heart J Cardiovasc Imaging. 2012;13(9):763–75
Weigand S, Karl M, Brkic A et al. The impact of multipole pacing on left ventricular function in patients with cardiac resynchronization therapy - A real-time three-dimensional echocardiography approach. Int J Cardiol. 2018;272:238–43
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Weigand, S., Kolb, C. Optimierung der kardialen Resynchronisationstherapie. CV 19, 33–37 (2019). https://doi.org/10.1007/s15027-019-1540-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s15027-019-1540-2