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Eckpfeiler der Prävention

Hypertonie und die Folgen für kognitive Funktionsstörungen und Demenz

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Zusammenfassung

Immer mehr Menschen erkranken an einer Demenz. Die Demenz entwickelt sich daher zu einer immensen Herausforderung in älter werdenden Gesellschaften. Entscheidend für die Prävention ist es, wesentliche Risikofaktoren einer Demenz rechtzeitig zu erkennen und zu behandeln – zweifellos gehört hierzu auch die Behandlung der arteriellen Hypertonie.

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Literatur

  1. Peltz CB, Corrada MM, Berlau DJ, Kawas CH. Cognitive impairment in nondemented oldest-old: Prevalence and relationship to cardiovascular risk factors. Alzheimers Dement. 2012;8(2):87–94

    Article  PubMed  PubMed Central  Google Scholar 

  2. Knecht S, Berger K. Einfluss vaskulärer Faktoren auf die Entwicklung einer Demenz. Dtsch Arztebl International. 2004;101(31-32): p. A–2185

    Google Scholar 

  3. Lüders S, Stöve S, Schrader J. Prävention der vaskulären Demenz. Internist 2012;53:223–31

    Article  PubMed  Google Scholar 

  4. Lüders S, Schrader J. Vaskuläre Demenz und Hypertonie. Dtsch med Wochenschr. 2015;140(21):1599–603.

    Article  PubMed  Google Scholar 

  5. Rönnemaa E, Zethelius B, Lannfelt L, Kilander L. Vascular Risk Factors and Dementia: 40-Year Follow-Up of a Population-Based Cohort. Dement Geriatr Cogn Disord. 2011;31(6):460–6

    Article  PubMed  Google Scholar 

  6. Lüders S, Saathoff U, Haller H et al. Häufigkeit kognitiver Funktionsstörungen bei Patienten mit Begleiterkrankungen. Ergebnisse des DEMTECT-Registers der Schlaganfall-Kommission der Deutschen Hypertonie-Gesellschaft. DHL-Kongress, Berlin 2012

    Google Scholar 

  7. Brayne C, Ince PG, Keage HAD et al. Education, the brain and dementia: neuroprotection or compensation? Brain. 2010;133(8):2210–6

    Article  PubMed  Google Scholar 

  8. Leys D, Henon H, Mackowiak-Cordoliani MA et al. Poststroke dementia. Lancet Neurol. 2005;4:752–9

    Article  PubMed  Google Scholar 

  9. Novak V, Hajjar I. The relationship between blood pressure and cognitive function. Nat Rev Cardiol. 2010;7:686–98

    PubMed  PubMed Central  Google Scholar 

  10. O’Donnell MJ, Xavier D, Liu L et al. Risk factors for ischemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2010;376:112–23

    Article  PubMed  Google Scholar 

  11. Tu JV. Reducing the global burden of stroke. Lancet. 2010;376:74–5

    Article  PubMed  Google Scholar 

  12. Vermeer SE, Prins ND, den Heijer T et al. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2013;348:1215–22

    Article  Google Scholar 

  13. Bernick C, Kuller L, Dulberg C et al. Silent MRI infarcts and the risk of future stroke: the cardiovascular health study. Neurology. 2001;57:1222–29

    Article  CAS  PubMed  Google Scholar 

  14. Watanabe N, Imai Y, Nagai K et al. Nocturnal blood pressure and silent cerebovascular lesions in elderly Japanese. Stroke. 1996;27:1319–27

    Article  CAS  PubMed  Google Scholar 

  15. Launer LJ, Ross GW, Petrovitch H et al. Midlife blood pressure and dementia: the Honolulu-Asia aging study. Neurobiol Aging. 2000;21(1):49–55

    Article  CAS  PubMed  Google Scholar 

  16. Freitag MH, Peila R, Masaki K et al. Midlife pulse pressure and incidence of dementia: the Honolulu-Asia Aging Study. Stroke. 2006;37(1):33–7

    Article  PubMed  Google Scholar 

  17. Kivipelto M, Helkala EL, Laakso MP et al. Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med. 2002;137(3):149–55

    Article  CAS  PubMed  Google Scholar 

  18. Launer LJ, Masaki K, Petrovitch H et al. The association between midlife blood pressure levels and late-life cognitive function. JAMA. 1995;274:1846–51

    Article  CAS  PubMed  Google Scholar 

  19. Morris MC, Scherr PA, Hebert LE et al. Association of incident Alzheimer’s disease and blood pressure measured from 13 years before to 2 years after diagnosis in a large community study. Arch Neurol. 2001;58:1640–46

    Article  CAS  PubMed  Google Scholar 

  20. Qiu C, Winblad B, Fratiglioni L. The age-dependent relation of blood pressure to cognitive function and dementia. Lancet Neurol. 2005;4(8):487–99

    Article  PubMed  Google Scholar 

  21. Knecht S, Wersching H, Lohmann H et al. High-normal blood pressure is associated with poor cognitive performance. Hypertension. 2008;51(3): 663–8

    Article  CAS  PubMed  Google Scholar 

  22. Kalaria RN. Vascular basis for brain degeneration: faltering controls and risk factors for dementia. Nutr Rev. 2010;68 Suppl 2:S74–87

    Article  PubMed  PubMed Central  Google Scholar 

  23. Beauchet O, Celle S, Roche F et al. Blood pressure levels and brain volume reduction: a systematic review and meta-analysis. J Hypertens. 2013; 1(8):1502–16

    Article  Google Scholar 

  24. Skoog I, Lernfelt B, Landahl S et al. A. 15-year longitudinal study of blood pressure and dementia. Lancet. 1996;347:1141–5

    Article  CAS  PubMed  Google Scholar 

  25. Stewart R, Xue QL, Masaki K et al. Change in blood pressure and incident dementia: a 32-year prospective study. Hypertension. 2009;54(2):233–40

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Kilander L, Nyman H, Boberg M et al. Hypertension Is Related to Cognitive Impairment: A 20-Year Follow-up of 999 Men. Hypertension. 1998;31(3):780–6

    Article  CAS  PubMed  Google Scholar 

  27. Sharp SI, Aarsland D, Day S et al. Hypertension is a potential risk factor for vascular dementia: systematic review. Int J Geriatr Psychiatry. 2011;26(7):661–9

    Article  PubMed  Google Scholar 

  28. Ueda K, Kawano H, Hasuo Y, Fujishima M. Prevalence and etiology of dementia in a Japanese community. Stroke. 1992;23(6):798–803

    Article  CAS  PubMed  Google Scholar 

  29. Yoshitake T, Kiyohara Y, Kato I et al. Incidence and risk factors of vascular dementia and Alzheimer’s disease in a defined elderly Japanese population: the Hisayama Study. Neurology. 1995;45(6):1161–8

    Article  CAS  PubMed  Google Scholar 

  30. Power MC, Weuve J, Gagne JJ et al. The association between blood pressure and incident Alzheimer disease: a systematic review and meta-analysis. Epidemiology. 2011;22(5):646–59

    Article  PubMed  PubMed Central  Google Scholar 

  31. Meng XF, Yu JT, Wang HF et al. Midlife vascular risk factors and the risk of Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014;42(4):1295–310

    PubMed  Google Scholar 

  32. Corrada M. Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study. Alzheimer’s Association International Conference 2014, Abstract P2–083

    Google Scholar 

  33. Gorelick PB, Scuteri A, Black SE et al. Vascular Contributions to Cognitive Impairment and Dementia. A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2011;42:2672–713

    Article  PubMed  PubMed Central  Google Scholar 

  34. Haag MDM, Hofman A, Koudstaal PJ et al. Duration of antihypertensive drug use and risk of dementia. A prospective cohort study. Neurology. 2009;72:1727–34

    Article  CAS  PubMed  Google Scholar 

  35. Forette F, Seux ML, Staessen JA et al. The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study. Arch Intern Med. 2002;162(18):2046–52

    Article  PubMed  Google Scholar 

  36. Peila R, White LR, Masaki K et al. Reducing the risk of dementia. Efficacy of long-term treatment of hypertension. Stroke. 2006;37:1165–70

    Article  PubMed  Google Scholar 

  37. Tzourio C, Anderson C, Chapman N et al. Effects of blood pressure lowering with perindopril and indapamide therapy on dementia and cognitive decline in patients with cerebrovascular disease. Arch Intern Med. 2003;163:1069–75

    Article  CAS  PubMed  Google Scholar 

  38. Peters R, Beckett N, Forette F et al. Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial. Lancet. 2008;7:683–9

    Article  CAS  PubMed  Google Scholar 

  39. Sugiyama T, Lee JD, Shimizu H et al. Influence of treated blood pressure on progression of silent cerebral infarction. J Hypertens. 1999;17:679–84

    Article  CAS  PubMed  Google Scholar 

  40. Duron E, Rigaud AS, Dubail D et al. Effects of antihypertensive therapy on cognitive decline in Alzheimer’s disease. Am J Hypertens. 2009;22:1020–4

    Article  CAS  PubMed  Google Scholar 

  41. Böhm M, Schumacher H, Leong D et al. Systolic Blood Pressure Variation and Mean Heart Rate Is Associated With Cognitive Dysfunction in Patients With High Cardiovascular Risk. Hypertension. 2015;65(3):651–61

    Article  PubMed  Google Scholar 

  42. van der Wardt V, Logan P, Conroy S et al. Antihypertensive Treatment in People With Dementia. J Am Med Dir Assoc. 2014;15(9):620–9

    Article  PubMed  Google Scholar 

  43. Beishon LC, Harrison JK, Harwood RH et al. The evidence for treating hypertension in older people with dementia: a systematic review. J Hum Hypertens. 2014;28(5):283–7

    Article  CAS  PubMed  Google Scholar 

  44. Ohrui T, Tomita N, Sato-Nakagawa T et al. Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression. Neurology. 2004;63(7):1324–5

    Article  CAS  PubMed  Google Scholar 

  45. Kaiser EA, Lotze U, Schäfer HH. Increasing complexity: which drug class to choose for treatment of hypertension in the elderly? Clin Interv Aging. 2014;9:459–75

    PubMed  PubMed Central  Google Scholar 

  46. Lehrl S, Gräßel E, Eicke C. Wirkung von Felodipin bei hypertonen Patienten mit leichten Hirnleistungsstörungen in einer randomisierten Doppelblindstudie. Dtsch med Wochenschr. 2000;125(45):1350–6

    Article  CAS  PubMed  Google Scholar 

  47. Tedesco MA, Ratti G, Mennella S et al. Comparison of losartan and hydrochlorothiazide on cognitive function and quality of life in hypertensive patients. Am J Hypertension. 1999;12:1130–4

    Article  CAS  Google Scholar 

  48. Inaba S, Iwai M, Furuno M et al. Continuous Activation of Renin-Angiotensin System Impairs Cognitive Function in Renin/Angiotensinogen Transgenic Mice. Hypertension. 2009;53:356

    Article  CAS  PubMed  Google Scholar 

  49. Wright JW, Harding JW. The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer’s disease. J Renin Angiotensin Aldosterone Syst. 2008;9(4):226–37

    Article  CAS  PubMed  Google Scholar 

  50. Xie W, Zhu D, Ji L et al. Angiotensin-(1-7) improves cognitive function in rats with chronic cerebral hypoperfusion. Brain Res. 2014;1573:44–53

    Article  CAS  PubMed  Google Scholar 

  51. Sink KM, Leng X, Williamson J et al. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension. Arch Intern Med. 2009;169(13):1195–202

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Chiu WC, Ho WC, Lin MH et al. Angiotension receptor blockers reduce the risk of dementia. J Hypertens. 2014;32(4):938–47

    Article  CAS  PubMed  Google Scholar 

  53. Fogari R, Preti P, Mugellini A et al. Influence of losartan and atenolol on cognitive function in very elderly hypertensive patients. Am J Hypertens. 2002;15:36A

    Google Scholar 

  54. Levi Marpillat N, Macquin-Mavier I, Tropeano AI et al. Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis. J Hypertens. 2013;31(6):1073–82

    Article  CAS  PubMed  Google Scholar 

  55. Schrader J, Lüders S, Kulschewski A et al. MOSES Study Group. Morbidity and Mortality After Stroke, Eprosartan Compared with Nitrendipine for Secondary Prevention: principal results of a prospective randomized controlled study (MOSES). Stroke. 2005;36(6):1218–26

    Article  CAS  PubMed  Google Scholar 

  56. Gelber RP, Ross GW, Petrovitch H et al. Antihypertensive medication use and risk of cognitive impairment: The Honolulu-Asia Aging Study. Neurology. 2013;81(10):888–95

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Joachim Schrader.

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Die Autoren erklären, dass sie sich bei der Erstellung des Beitrages von keinen wirtschaftlichen Interessen leiten ließen und dass keine potenziellen Interessenkonflikte vorliegen. Der Verlag erklärt, dass die inhaltliche Qualität des Beitrags von zwei unabhängigen Gutachtern geprüft wurde. Werbung in dieser Zeitschriftenausgabe hat keinen Bezug zur CME-Fortbildung. Der Verlag garantiert, dass die CME-Fortbildung sowie die CME-Fragen frei sind von werblichen Aussagen und keinerlei Produktempfehlungen enthalten. Dies gilt insbesondere für Präparate, die zur Therapie des dargestellten Krankheitsbildes geeignet sind.

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Schrader, J., Lüders, S. Hypertonie und die Folgen für kognitive Funktionsstörungen und Demenz. CV 16, 49–56 (2016). https://doi.org/10.1007/s15027-016-0744-y

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