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Perspektiven zu cholesterinwirksamer Behandlung 2014

  • Schwerpunkt_Lipidologie
  • Published:
CardioVasc Aims and scope

Zusammenfassung

Cholesterinwirksame Therapie ist eine Schlüsselmaßnahme in der Prävention kardiovaskulärer Erkrankungen. Dass dieses Kapitel der Gesundheitsversorgung mit der Statintherapie nicht abgeschlossen ist, wurde bei den diesjährigen großen internationalen Kardiologiekongressen sichtbar. Große Erwartungen an weitere Entwicklungen zur Erhöhung der Wirksamkeit cholesterinsenkender Behandlung lassen eine Vielzahl von Ergebnissen klinischer Programme mit den PCSK9-Inhibitoren erkennen. Schon kurze Zeit nach der Entdeckung klinischer Implikationen von PCSK9-Mutationen liegen größere Studien zu Wirkungen und Verträglichkeit monoklonaler Antikörper gegen PCSK9 vor. Der Beitrag führt in Erkenntnisse zur Funktion von PCSK9 ein und erlaubt eine Bewertung therapeutischer Wirkungen auf dem Boden einer systematischen Analyse bisher vorgestellter Studien. Die beträchtliche LDL-Cholesterin-senkende Potenz bei einem verblüffend guten Sicherheitsprofil weisen auf Behandlungsoptionen in klinischen Konstellationen, für die bislang „unmet needs“ bestehen.

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Authors and Affiliations

  1. Praxis Dres. T. Beckenbauer und S. Maierhof, Am Markt 11, 28195, Bremen, Deutschland

    Gerald Klose

  2. Physiologisches Institut, Fachbereich Medizin der Justus-Liebig-Universität, Gießen, Deutschland

    Rainer Schulz

  3. Klinik für Innere Medizin II, Universitätsklinikum Ulm, Ulm, Deutschland

    Wolfgang Koenig

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Klose, G., Schulz, R. & Koenig, W. Perspektiven zu cholesterinwirksamer Behandlung 2014. CV 14, 50–60 (2014). https://doi.org/10.1007/s15027-014-0521-8

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