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Das sogenannte "Chemobrain"

Kognitive Dysfunktion bei Krebskranken - ein oft unterbewertetes Symptom

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Literatur:

  1. Lange M et al. Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors. Ann Oncol. 2019;30(12):1925-40

  2. Wefel JS et al. International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. Lancet Oncol. 2011;12(7):703-8

  3. Lycke M et al. Predictors of baseline cancer-related cognitive impairment in cancer patients scheduled for a curative treatment. Psychooncology. 2017;26(5):632-9

  4. Janelsins MC et al. Prevalence, mechanisms, and management of cancer-related cognitive impairment. Int Rev Psychiatry. 2014;26(1):102-13

  5. Ganz PA et al. Cognitive complaints after breast cancer treatments: examining the relationship with neuropsychological test performance. J Natl Cancer Inst. 2013;105(11):791-801

  6. Paquet L et al. Testing a novel account of the dissociation between self-reported memory problems and memory performance in chemotherapy-treated breast cancer survivors. Psychooncology. 2018;27(1):171-77

  7. Allen DH, Loughan AR. Impact of Cognitive Impairment in Patients with Gliomas. Semin Oncol Nurs. 2018;34(5):528-46

  8. Ahles TA, Root JC. Cognitive Effects of Cancer and Cancer Treatments. Annu Rev Clin Psychol. 2018;14:425-51

  9. Hardy SJ et al. Cognitive Changes in Cancer Survivors. Am Soc Clin Oncol Educ Book. 2018;38:795-806

  10. Koppelmans V et al. Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. J Clin Oncol. 2012;30(10):1080-6

  11. Hermelink K et al. Chemotherapy and Post-traumatic Stress in the Causation of Cognitive Dysfunction in Breast Cancer Patients. J Natl Cancer Inst. 2017;109(10):10.1093/jnci/djx057

  12. McGinty HL et al. Cognitive functioning in men receiving androgen deprivation therapy for prostate cancer: a systematic review and meta-analysis. Support Care Cancer. 2014;22(8):2271-80

  13. Ahles TA et al. Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol. 2010;28(29):4434-40

  14. Schilder CM et al. Cognitive functioning of postmenopausal breast cancer patients before adjuvant systemic therapy, and its association with medical and psychological factors. Crit Rev Oncol Hematol. 2010;76(2):133-41

  15. Hermelink K et al. Short-term effects of treatment-induced hormonal changes on cognitive function in breast cancer patients: results of a multicenter, prospective, longitudinal study. Cancer. 2008;113(9):2431-9

  16. Ganz PA et al. Cognitive function after the initiation of adjuvant endocrine therapy in early-stage breast cancer: an observational cohort study. J Clin Oncol. 2014;32(31):3559-67

  17. Bender CM et al. Patterns of change in cognitive function with anastrozole therapy. Cancer. 2015;121(15):2627-3

  18. Joly F et al. Prospective Evaluation of the Impact of Antiangiogenic Treatment on Cognitive Functions in Metastatic Renal Cancer. Eur Urol Focus. 2016;2(6):642-9

  19. McGinnis GJ, Raber J. CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy. Immunotherapy. 2017;9(11):929-41

  20. Lawrie TA et al. Long-term neurocognitive and other side effects of radiotherapy, with or without chemotherapy, for glioma. Cochrane Database Syst Rev. 2019;8(8):CD013047

  21. Byeongsang Oh 1 et al. Effect of medical Qigong on cognitive function, quality of life, and a biomarker of inflammation in cancer patients: a randomized controlled trial. Support Care Cancer. 2012;20(6):1235-42

  22. Jalali R et al. Efficacy of Stereotactic Conformal Radiotherapy vs Conventional Radiotherapy on Benign and Low-Grade Brain Tumors: A Randomized Clinical Trial. JAMA Oncol. 2017;3(10):1368-76

  23. Brown PD et al; for NRG Oncology. Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001. J Clin Oncol. 2020;38(10):1019-29

  24. Grosu AL et al. Whole-brain irradiation with hippocampal sparing and dose escalation on metastases: neurocognitive testing and biological imaging (HIPPORAD) - a phase II prospective randomized multicenter trial (NOA-14, ARO 2015-3, DKTK-ROG). BMC Cancer. 2020;20(1):532

  25. https://nccn.gov zuletzt abgerufen: 26.7.2023

  26. Allen DH et al. Assessment and Management of Cancer- and Cancer Treatment-Related Cognitive Impairment. Nurse Pract. 2018;14(4):217-24

  27. Wefel JS et al. International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. Lancet Oncol. 2011;12(7):703-8

  28. Rick O, König V. Krebsbedingte kognitive Dysfunktion. Cancer-related cognitive dysfunction. Die Onkologie. 2022; 28(9)

  29. Scherwath A et al. Psychometric evaluation of a neuropsychological test battery measuring cognitive dysfunction in cancer patients--recommendations for a screening tool. Fortschr Neurol Psychiatr. 2008;76(10):583-93

  30. Schmitz KH et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc. 2010;42(7):1409-26

  31. Fardell JE, et al. Cognitive impairments caused by oxaliplatin and 5-fluorouracil chemotherapy are ameliorated by physical activity.Psychopharmacology (Berl). 2012;220(1):183-93

  32. Hines S et al. The effectiveness of psychosocial interventions for cognitive dysfunction in cancer patients who have received chemotherapy: a systematic review. Worldviews Evid Based Nurs. 2014;11(3):187-93

  33. Bray VJ et al. Evaluation of a Web-Based Cognitive Rehabilitation Program in Cancer Survivors Reporting Cognitive Symptoms After Chemotherapy. J Clin Oncol. 2017;35(2):217-25

  34. Kesler S et al. Cognitive training for improving executive function in chemotherapy-treated breast cancer survivors. Clin Breast Cancer. 2013;13(4):299-306

  35. Fernandes HA et al. Cognitive rehabilitation for cancer-related cognitive dysfunction: a systematic review. Support Care Cancer. 2019;27(9):3253-79

  36. Karschnia P et al. Pharmacologic management of cognitive impairment induced by cancer therapy. Lancet Oncol. 2019;20(2):e92-e102

  37. Fan HG et al. The influence of erythropoietin on cognitive function in women following chemotherapy for breast cancer. Psychooncology. 2009;18(2):156-61

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Schilling, G. Das sogenannte "Chemobrain". Im Fokus Onkologie 26, 52–57 (2023). https://doi.org/10.1007/s15015-023-3200-8

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  • DOI: https://doi.org/10.1007/s15015-023-3200-8

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