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Autoimmunerkrankungen

Notwendige Diagnostik bei Immundermatosen im Kindesalter

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Pädiatrie Aims and scope

Eine neu aufgetretene Dermatitis kann primäres klinischen Zeichen einer chronischen autoimmunologischen oder autoinflammatorischen Erkrankung im Kindesalter sein. Selten sind Immundermatosen bei Kindern für eine chronische Entzündungserkrankung spezifisch. In den meisten Fällen ist eine umfassende klinische, laborchemische und auch bildgebende Diagnostik notwendig.

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Literatur

  1. Van Noort JM, Amor S. Cell biology of autoimmune diseases. Int Rev Cytol. 1998;178:127–206

    Article  PubMed  Google Scholar 

  2. McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M, Mansfield E, Gadina M, Karenko L, Pettersson T, McCarthy J, Frucht DM, Aringer M, Torosyan Y, Teppo AM, Wilson M, Karaarslan HM, Wan Y, Todd I, Wood G, Schlimgen R, Kumarajeewa TR, Cooper SM, Vella JP, Amos CI, Mulley J, Quane KA, Molloy MG, Ranki A, Powell RJ, Hitman GA, O’Shea JJ, Kastner DL. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell. 1999 Apr 2;97(1):133–44

    Article  Google Scholar 

  3. McGonagle D, Aziz A, Dickie LJ, McDermott MF. An integrated classification of pediatric inflammatory diseases, based on the concepts of autoinflammation and the immunological disease continuum. Pediatr Res. 2009 May;65(5 Pt 2):38R–45R

    Article  PubMed  Google Scholar 

  4. Dainichi T, Hanakawa S, Kabashima K. Classification of inflammatory skin diseases: a proposal based on the disorders of the three-layered defense systems, barrier, innate immunity and acquired immunity. J Dermatol Sci. 2014 Nov;76(2):81–9

    Article  PubMed  Google Scholar 

  5. Feder HM Jr. Periodic fever, aphthous stomatitis, pharyngitis, adenitis: a clinical review of a new syndrome. Curr Opin Pediatr. 2000Jun;12(3):253–6

    Article  PubMed  Google Scholar 

  6. Sandrine B, Goebeler M. Vasculitis in childhood — a dermatological approach. J Dtsch Dermatol Ges. 2014 Feb;12(2):124–9

    PubMed  Google Scholar 

  7. Lowry CA, Pilkington CA. Juvenile dermatomyositis: extramuscular manifestations and their management. Curr Opin Rheumatol. 2009 Nov;21(6):575–80

    Article  CAS  PubMed  Google Scholar 

  8. Foeldvari I. New developments in juvenile systemic and localized scleroderma. Rheum Dis Clin North Am. 2013 Nov;39(4):905–20

    Article  PubMed  Google Scholar 

  9. Balato N, Megna M, Napolitano M, Balato A, Scalvenzi M, Cirillo T, Gallo L, Ayala F. Psoriasis in Children: a Review. Curr Pediatr Rev. 2015 Apr 30

  10. Wouters CH, Maes A, Foley KP, Bertin J, Rose CD. Blau syndrome, the prototypic auto-inflammatory granulomatous disease. Pediatr Rheumatol Online J. 2014 Aug 6;12:33

    Article  Google Scholar 

  11. Kessel C, Holzinger D, Foell D. Phagocyte-derived S100 proteins in autoinflammation: putative role in pathogenesis and usefulness as biomarkers. Clin Immunol. 2013 Jun;147(3):229–41

    Article  CAS  PubMed  Google Scholar 

  12. Esposito S, Ascolese B, Senatore L, Bosis S, Verrecchia E, Cantarini L, Rigante D. Current advances in the understanding and treatment of mevalonate kinase deficiency. Int J Immunopathol Pharmacol. 2014 Oct-Dec;27(4):491–8

    CAS  PubMed  Google Scholar 

  13. Yaris N, Cakir M, Sözen E, Cobanoglu U. Analysis of children with peripheral lymphadenopathy. Clin Pediatr (Phila). 2006 Jul;45(6):544–9

    Article  Google Scholar 

  14. Oguz A, Karadeniz C, Temel EA, Citak EC, Okur FV. Evaluation of peripheral lymphadenopathy in children. Pediatr Hematol Oncol. 2006 Oct-Nov;23(7):549–61

    Article  PubMed  Google Scholar 

  15. Rajasekaran K, Krakovitz P. Enlarged neck lymph nodes in children. Pediatr Clin North Am. 2013 Aug;60(4):923–36

    Article  PubMed  Google Scholar 

  16. Lang S, Kansy B. [Diseases of the cervical lymph nodes in childhood]. Laryngorhinootologie. 2014 Mar;93 Suppl 1:S49–69

    PubMed  Google Scholar 

  17. Sánchez-Manubens J, Bou R, Anton J. Diagnosis and classification of Kawasaki disease. J Autoimmun. 2014 Feb-Mar;48-49:113–7

    Article  PubMed  Google Scholar 

  18. Collado Ramos P. Ultrasound imaging in juvenile idiopathic arthritis for the rheumatologist. Clin Exp Rheumatol. 2014 Jan-Feb;32(1 Suppl 80):S34–41

    PubMed  Google Scholar 

  19. Ernste FC, Reed AM. Recent advances in juvenile idiopathic inflammatory myopathies. Curr Opin Rheumatol. 2014 Nov;26(6):671–8

    Article  CAS  PubMed  Google Scholar 

  20. Hull KM, Wong K, Wood GM, Chu WS, Kastner DL. Monocytic fasciitis: a newly recognized clinical feature of tumor necrosis factor receptor dysfunction. Arthritis Rheum. 2002 Aug;46(8):2189–94

    Article  CAS  PubMed  Google Scholar 

  21. Kaiser D, Bolt I, Hofer M, Relly C, Berthet G, Bolz D, Saurenmann T. Chronic nonbacterial osteomyelitis in children: a retrospective multicenter study. Pediatr Rheumatol Online J. 2015 Jun 19;13:25

    Article  PubMed Central  PubMed  Google Scholar 

  22. Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ. Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J. 2013 Dec 23;11(1):47

    Article  PubMed Central  PubMed  Google Scholar 

  23. Stern SM, Ferguson PJ. Autoinflammatory bone diseases. Rheum Dis Clin North Am. 2013 Nov;39(4):735–49

    Article  PubMed  Google Scholar 

  24. Punzi L, Furlan A, Podswiadek M, Gava A, Valente M, De Marchi M, Peserico A. Clinical and genetic aspects of Blau syndrome: a 25-year follow-up of one family and a literature review. Autoimmun Rev. 2009 Jan;8(3):228–32

    Article  CAS  PubMed  Google Scholar 

  25. Aksentijevich, I., Masters, S. L., Ferguson, P. J., Dancey, P., Frenkel, J., van Royen-Kerkhoff, A., Laxer, R., Tedgard, U., Cowen, E. W., Pham, T.-H., Booty, M., Estes, J. D., and 30 others. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. New Eng. J. Med. 2009;360: 2426–37

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Caso F, Rigante D, Vitale A, Lucherini OM, Costa L, Atteno M, Compagnone A, Caso P, Frediani B, Galeazzi M, Punzi L, Cantarini L. Monogenic autoinflammatory syndromes: state of the art on genetic, clinical, and therapeutic issues. Int J Rheumatol. 2013;2013:513782

    Article  PubMed Central  PubMed  Google Scholar 

  27. Kallinich T Periodische Fiebersyndrome. In: Wagner, Dannecker, Pädiatrische Rheumatologie 2. Auflage 2013; S 435

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Authors and Affiliations

  1. Klinik für Allgemeine Pädiatrie, Universitätsklinikum SH, Campus Kiel, Schwanenweg 20, 24105, Kiel, Deutschland

    Philipp von Bismarck

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  1. Philipp von Bismarck
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Der Autor erklärt, dass bei der Erstellung des Beitrags kein Interessenkonflikt vorlag.

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von Bismarck, P. Notwendige Diagnostik bei Immundermatosen im Kindesalter. Pädiatrie 27 (Suppl 7), 21–30 (2015). https://doi.org/10.1007/s15014-015-0457-1

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  • DOI: https://doi.org/10.1007/s15014-015-0457-1

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