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Physiologische Infektanfälligkeit oder Immundefekt?

Ungewöhnliche Infektionen

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Pädiatrie Aims and scope

Der Titel lässt einen stutzen: Der Begriff „Infektanfälligkeit“ impliziert nämlich eine — wodurch auch immer — entstandene Abwehrschwäche gegenüber infektiösen Erregern, während „physiologisch“ auf Verhältnisse hinweist, die beim Gesunden vorliegen. Kann man also gleichzeitig gesund sein und ein geschwächtes Immunsystem haben? Was ist nun wissenschaftlich betrachtet „Infektanfälligkeit“?

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Literatur

  1. Okkes IM, Oskam SK, Lamberts H. The probability of specific diagnoses for patients presenting with common symptoms to dutch family physicians. J Fam Pract. 2002 Jan;51(1):31–6.

    CAS  PubMed  Google Scholar 

  2. Casanova JL, Abel L. The human model: A genetic dissection of immunity to infection in natural conditions. Nat Rev Immunol. 2004 Jan;4(1):55–66.

    Article  CAS  PubMed  Google Scholar 

  3. Nafstad P, Hagen JA, Oie L, Magnus P, Jaakkola JJ. Day care centers and respiratory health. Pediatrics. 1999 Apr;103(4 Pt 1):753–8.

    Article  CAS  PubMed  Google Scholar 

  4. The hamburg cholera epidemic. Br Med J. 1893 Feb 25;1(1678):429–30.

  5. Smith GJ, Bahl J, Vijaykrishna D, Zhang J, Poon LL, Chen H, et al. Dating the emergence of pandemic influenza viruses. Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709–12.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Caulfield LE, de Onis M, Blossner M, Black RE. Undernutrition as an underlying cause of child deaths associated with diarrhea, pneumonia, malaria, and measles. Am J Clin Nutr. 2004 Jul;80(1):193–8.

    CAS  PubMed  Google Scholar 

  7. Wahn V, Ehl S, Niehues T. Infektanfälligkeit — versuch einer definition. Allergologie. 2003;26(10).

  8. International Union of Immunological Societies Expert Committee on Primary Immunodeficiencies, Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H, et al. Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol. 2009 Dec;124(6):1161–78.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Baumann U, Belohradsky BH, Friedrich W, Linde R, Niehues T, Renner E, et al. Primäre Immundefekte — Warnzeichen und Algorithmen zur Diagnosefindung. 1. ed. Bremen: UNI-MED SCIENCE; 2010.

  10. Farmand S, Baumann U, von Bernuth H, Borte M, Foerster-Waldl E, et al. Interdisciplinary AWMF guideline for the diagnostics of primary immunodeficiency. Klin Padiatr. 2011 Nov;223(6):378–85.

    Article  CAS  PubMed  Google Scholar 

  11. Abel L, Plancoulaine S, Jouanguy E, Zhang SY, Mahfoufi N, Nicolas N, et al. Age-dependent mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood. J Pediatr. 2010 Oct;157(4):623,9, 629.e1.

    Article  PubMed  Google Scholar 

  12. Fieschi C, Casanova JL. The role of interleukin-12 in human infectious diseases: Only a faint signature. Eur J Immunol. 2003 Jun;33(6):1461–4.

    Article  CAS  PubMed  Google Scholar 

  13. Bakare N, Menschik D, Tiernan R, Hua W, Martin D. Severe combined immunodeficiency (SCID) and rotavirus vaccination: Reports to the vaccine adverse events reporting system (VAERS). Vaccine. 2010 Sep 14;28(40):6609–12.

    Article  PubMed  Google Scholar 

  14. Wolska-Kusnierz B, Bajer A, Caccio S, Heropolitanska-Pliszka E, Bernatowska E, Socha P, et al. Cryptosporidium infection in patients with primary immunodeficiencies. J Pediatr Gastroenterol Nutr. 2007 Oct;45(4):458–64.

    Article  PubMed  Google Scholar 

  15. Plebani A, Soresina A, Rondelli R, Amato GM, Azzari C, Cardinale F, et al. Clinical, immunological, and molecular analysis in a large cohort of patients with X-linked agammaglobulinemia: An italian multicenter study. Clin Immunol. 2002 9;104(3):221–30.

    Article  CAS  PubMed  Google Scholar 

  16. Quinti I, Soresina A, Spadaro G, Martino S, Donnanno S, Agostini C, et al. Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency. J Clin Immunol. 2007 May;27(3):308–16.

    Article  PubMed  Google Scholar 

  17. Schimke LF, Sawalle-Belohradsky J, Roesler J, Wollenberg A, Rack A, Borte M, et al. Diagnostic approach to the hyper-IgE syndromes: Immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. J Allergy Clin Immunol. 2010 Sep;126(3):611,7.e1.

    Article  CAS  PubMed  Google Scholar 

  18. van den Berg JM, van Koppen E, Ahlin A, Belohradsky BH, Bernatowska E, Corbeel L, et al. Chronic granulomatous disease: The european experience. PLoS One. 2009;4(4):e5234.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Yarmohammadi H, Estrella L, Doucette J, Cunningham-Rundles C. Recognizing primary immune deficiency in clinical practice. Clin Vaccine Immunol. 2006 Mar;13(3):329–32.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Gruber C, Keil T, Kulig M, Roll S, Wahn U, Wahn V, et al. History of respiratory infections in the first 12 yr among children from a birth cohort Pediatr Allergy Immunol. 2008 Sep;19(6):505–12.

    Article  PubMed  Google Scholar 

  21. Okkes IM, Polderman GO, Fryer GE, Yamada T, Bujak M, Oskam SK, et al. The role of family practice in different health care systems: A comparison of reasons for encounter, diagnoses, and interventions in primary care populations in the netherlands, japan, poland, and the united states. J Fam Pract. 2002 Jan;51(1):72–3.

    CAS  PubMed  Google Scholar 

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Der Autor erklärt, dass bei der Erstellung des Beitrags kein Interessenkonflikt vorlag.

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Baumann, U. Physiologische Infektanfälligkeit oder Immundefekt?. Pädiatrie 26 (Suppl 1), 56–61 (2014). https://doi.org/10.1007/s15014-014-0462-9

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  • DOI: https://doi.org/10.1007/s15014-014-0462-9

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