Skip to main content
SpringerLink
Log in

Integrative Medizin

Krebs und Stress — Folgen und mögliche Auswege

  • Fortbildung
  • Published:
gynäkologie + geburtshilfe Aims and scope

Mit circa einer halben Million Neuerkrankungen gehört Krebs, insbesondere Brust-, Prostata-, Darm- und Lungenkrebs, zu den häufigsten Erkrankungen und ist trotz verbesserter Diagnose- und Behandlungsmaßnahmen die zweithäufigste Todesursache in Deutschland. Stress als begünstigender Faktor für eine Tumorprogression bei verschiedenen Krebserkrankungen ist seit Längerem bekannt. Die Rolle von Stress bei der Krebsentstehung ist hingegen noch nicht eindeutig geklärt. Mind-Body-medizinische Verfahren könnten als Anti-Stress-Interventionen den Verlauf von Krebserkrankungen positiv beeinflussen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Albert US et al. (2016) Diagnostik und Therapie primärer und metastasierter Mammakarzinome - Gynäkologische Probleme bei Mammakarzinompatientinnen. In: http://www.ago-online.de/fileadmin/downloads/leitlinien/mamma/Maerz2016/de/2016D%2025_Gyna%CC%88kologische%20Probleme.pdf: AGO Arbeitsgemeinschaft Gynäkologische Onkologie e.V.

  2. Bleiker EM, Hendriks JH, Otten JD, Verbeek AL, van der Ploeg HM. Personality factors and breast cancer risk: a 13-year follow-up. Journal of the National Cancer Institute. 2008;100:213–218.

    Article  PubMed  Google Scholar 

  3. Carlson LE et al. (2015) Mindfulness-based cancer recovery and supportive-expressive therapy maintain telomere length relative to controls in distressed breast cancer survivors. Cancer 121: 476–84.

    Article  PubMed  Google Scholar 

  4. Carlson LE, Tamagawa R, Stephen J, Drysdale E, Zhong L, Speca M. Randomized-controlled trial of mindfulness-based cancer recovery versus supportive expressive group therapy among distressed breast cancer survivors (MINDSET): long-term follow-up results. Psychooncology. 2016 Jul;25(7):750–9. doi: 10.1002/pon.4150. Epub 2016 May 18.

    Article  PubMed  Google Scholar 

  5. Chida Y, Steptoe A, Powell LH: Religiosity/spirituality and mortality. A systematic quantitative review. Psychother Psychosom 2009; 78: 81–90.

    Article  PubMed  Google Scholar 

  6. Cohen L, Cole SW, Sood AK, Prinsloo S, Kirschbaum C, Arevalo JM, Jennings NB, Scott S, Vence L, Wei Q, Kentor D, Radvanyi L, Tannir N, Jonasch E, Tamboli P, Pisters L. Depressive symptoms and cortisol rhythmicity predict survival in patients with renal cell carcinoma: role of inflammatory signaling. PLoS One. 2012;7(8):e42324.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Derry et.al. (2015) Yoga and self-reported cognitive problems in breast cancer survivors: a randomized controlled trial. Psychooncology 24: 958–66. Horneber M et al. (2012) How many cancer patients use complementary and alternative medicine: a systematic review and metaanalysis. Integrative cancer therapies 11: 187-203.

    Article  PubMed  Google Scholar 

  8. Dobos G, et al. Integrating mindfulness in supportive cancer care: a cohort study on a mindfulness-based day care clinic for cancer survivors. Support Care Cancer. 2015.

  9. Dobos G, et al. Integrative oncology for breast cancer patients: introduction of an expert-based model. BMC Cancer. 2012

  10. Dobos G, Paul A. (Hg.) Mind-Body-Medizin, Elsevier München 2011.

  11. Duijts SF, Zeegers MP, Borne BV. The association between stressful life events and breast cancer risk: a meta-analysis. Int J Cancer. 2003 Dec 20;107 (6):1023–9.

    Google Scholar 

  12. Green McDonald P, O’Connell M, Lutgendorf SK (2013). Psychoneuroimmunology and cancer: a decade of discovery, paradigm shifts, and methodological innovations. Brain Behav Immun. 2013 Mar;30 Suppl:S1-9. doi: 10.1016/j.bbi.2013.01.003. Epub 2013 Jan 16.

  13. Hamer M, Chida Y, Molloy GJ. Psychological distress and cancer mortality. J Psychosom Res. 2009 Mar;66(3):255–8.

    Article  PubMed  Google Scholar 

  14. Hanahan, D.; Weinberg, R. A. (2011). „Hallmarks of Cancer: The Next Generation“. Cell 144(5): 646–674.

    Article  CAS  PubMed  Google Scholar 

  15. Huang HP et al. (2015) A meta-analysis of the benefits of mindfulness-based stress reduction (MBSR) on psychological function among breast cancer (BC) survivors. Breast Cancer. 2016 Jul;23(4):568–76. doi: 10.1007/s12282-015-0604-0. Epub 2015 Mar 28}.

    Article  PubMed  Google Scholar 

  16. Johns SA et al. (2015) Randomized controlled pilot study of mindfulness-based stress reduction for persistently fatigued cancer survivors. Psychooncology. 24(8):885–93. doi:10.1002/pon.3648. Epub 2014 Aug 17.

    Article  PubMed  Google Scholar 

  17. Kroenke CH, Kubzansky LD, Schernhammer ES, Holmes MD, Kawachi I. Social networks, social support, and survival after breast cancer diagnosis. J Clin Obncol. 1;24(7):1105-11.

  18. Kümmel S, Schmidt M. (2016) Diagnostik und Therapie primärer und metastasierter Mammakarzinome - Komplementäre Therapie „Survivorship“. In: http://www.ago-online.de/fileadmin/downloads/leitlinien/mamma/Maerz2016/de/2016D%2024_Komplementaere%20Therapie.pdf: AGO Arbeitsgemeinschaft Gynäkologische Onkologie e.V.

  19. Kwok A et al. (2015) Dietary experiences and support needs of women who gain weight following chemotherapy for breast cancer. Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer 23: 1561–1568.

    Article  Google Scholar 

  20. Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M. Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003 Mar 1;157(5):415–23.

    Article  PubMed  Google Scholar 

  21. Lutgendorf SK, De Geest K, Bender D, Ahmed A, Goodheart MJ, Dahmoush L, Zimmerman MB, Penedo FJ, Lucci JA 3rd, Ganjei-Azar P, Thaker PH, Mendez L, Lubaroff DM, Slavich GM, Cole SW, Sood AK. Social influences on clinical outcomes of patients with ovarian cancer. J Clin Oncol. 2012 Aug 10;30(23):2885–90.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Mills PJ, Schneider RH, Hill D, Walton KG, Wallace RK. Beta-adrenergic receptor sensitivity in subjects practicing transcendental meditation. J Psychosom Res. 1990;34(1):29–33.

    Article  CAS  PubMed  Google Scholar 

  23. Morgan N, Irwin MR, Chung M, Wang C. (2014). The effects of mind-body therapies on the immune system: meta-analysis. PLoS One. 2014 Jul 2;9(7):e100903. doi: 10.1371/journal.pone.0100903. eCollection 2014.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Ornish D et al. (2005). Intensive lifestyle changes may affect the progression of prostate cancer. J Urol. 2005 Sep;174(3):1065–9; discussion 1069-70.

    Article  PubMed  Google Scholar 

  25. Palesh O et al. (2014) Actigraphy-measured sleep disruption as a predictor of survival among women with advanced breast cancer. Sleep. 1;37(5):837–42. doi: 10.5665/sleep.3642.

    PubMed  PubMed Central  Google Scholar 

  26. Palesh O et al. (2016) RCT utilizing acupuncture for management of insomnia associated with cancer. Journal of Clinical Oncology, 2015 ASCO Annual Meeting 33, No 15_suppl.

  27. Palesh O, Butler LD, Koopman C, Giese-Davis J, Carlson R, Spiegel D. Stress history and breast cancer recurrence. J Psychosom Res. 2007 Sep;63(3):233–9.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Petticrew M. Cancer-stress link: the truth. Nurs Times. 1999 Mar 3-9;95(9):52–3.

    CAS  PubMed  Google Scholar 

  29. Pinquart M, Duberstein PR. Associations of social networks with cancer mortality: a meta-analysis. Crit Rev Oncol Hematol. 2010 Aug;75(2):122–37.

    Article  PubMed  Google Scholar 

  30. Reynolds P, Kaplan GA. Social connections and risk for cancer: prospective evidence from the Alameda County Study. Behav Med. 1990 Fall;16(3):101–10.

    Article  CAS  PubMed  Google Scholar 

  31. Robert-Koch-Institut. Krebs in Deutschland 2011/2012. 10. Ausgabe, 2015. Zentrum für Krebsregisterdaten, GEKID. Gesundheitsberichterstattung des Bundes. Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (Hrsg). Berlin.

  32. Satin JR, et al.: Depression as a predictor of disease progression and moritality in cancer patients: a meta-analysis. Cancer 2009; 115: 5349–5361.

    Article  PubMed  Google Scholar 

  33. Sprehn GC, Chambers JE, Saykin AJ, Konski A, Johnstone PA. Decreased cancer survival in individuals separated at time of diagnosis: critical period for cancer pathophysiology? Cancer. 2009 Nov 1;115(21):5108–16.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Sprod LK (2015) Effects of yoga on cancer-related fatigue and global side-effect burden in older cancer survivors. Journal of Geriatric Oncology 6: 8–14.

    Article  PubMed  Google Scholar 

  35. Steele et al., 2007. Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003 Mar 1;157(5):415–23.

    Google Scholar 

  36. Thaker PH et al. (2006) Chronic Stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinomaNature Medicine 12, 939 - 944 (2006) Published online: 23 July 2006 doi:10.1038/nm1447

  37. Watkins JL et al., (2015) Clinical Impact of selective and non-selective beta blockers on survival in ovarian cancer patients. Cancer October 1; 121(19): 3444–3451. doi:10.1002/cncr.29392.

    CAS  Google Scholar 

  38. Zeng Y et al. (2014) Health benefits of qigong or tai chi for cancer patients: a systematic review and meta-analyses. Complementary therapies in medicine 22: 173–186.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universität Duisburg-Essen, Lehrstuhl für Naturheilkunde und Integrative Medizin, Kliniken Essen-Mitte, Knappschaftskrankenhaus, Am Deimelsberg 34a, 45276, Essen, Deutschland

    Gustav Dobos

  2. http://www.springermedizin.de

    Petra Voiß, Kyung-Eun Choi, Sherko Kümmel & Anna Paul

Authors
  1. Gustav Dobos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Petra Voiß
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyung-Eun Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sherko Kümmel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Anna Paul
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gustav Dobos.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dobos, G., Voiß, P., Choi, KE. et al. Krebs und Stress — Folgen und mögliche Auswege. gynäkologie + geburtshilfe 22, 24–29 (2017). https://doi.org/10.1007/s15013-017-1109-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15013-017-1109-z

Search

Navigation