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Liquid biopsy

Neue Biomarker für Diagnostik und Therapiemonitoring in der Onkologie

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gynäkologie + geburtshilfe Aims and scope

In die Tumordiagnostik kommt Bewegung. Während klassische Tumormarker bei Frühdiagnostik oder Screening nicht bedeutsam sind, erlaubt die durchflusszytometrische Bestimmung von Biomarkern in Makrophagen eine neue Form einer nicht invasiven Diagnostik („liquid biopsy“), mit der Tumoren früher erfasst und deren Malignität charakterisiert werden kann. Interessant sind zwei Biomarker, die fundamentale biophysikalische Prozesse detektieren und in allen Malignomen verändert sind. Damit wäre ein genereller Malignomnachweis („pan-cancer test“) denkbar. Noch ist der Stellenwert einer solchen Diagnostik umstritten. Einsatzmöglichkeiten bestehen bei der Früherkennung, Tumorcharakterisierung und beim Monitoring von Therapieverläufen.

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Authors and Affiliations

  1. 63512, Hainburg, Deutschland

    Johannes F. Coy

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  1. Johannes F. Coy
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Correspondence to Johannes F. Coy.

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Coy, J.F. Neue Biomarker für Diagnostik und Therapiemonitoring in der Onkologie. gynäkologie + geburtshilfe 21, 20–24 (2016). https://doi.org/10.1007/s15013-016-0966-1

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  • DOI: https://doi.org/10.1007/s15013-016-0966-1

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