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Hidradenitis suppurativa/Acne inversa

Langwierige Diagnose, hohe Rezidivrate

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hautnah dermatologie Aims and scope

Zusammenfassung

Die chronisch entzündliche Erkrankung Hidradenitis suppurativa/Acne inversa stellt sowohl Ärzte als auch Patienten vor große Herausforderungen. Bis zur Diagnose vergehen oft Jahre, die Rezidivrate ist erheblich. Die Wahl der Therapieoption ist entscheidend vom Gesundheitszustand des Patienten und vom Schweregrad der Erkrankung abhängig. Der folgende Beitrag gibt einen Überblick über bewährte und neue Therapieoptionen

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Literatur

  1. Revuz JE et al. Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies. J Am Acad Dermatol 2008; 59: 596–601

    Article  PubMed  Google Scholar 

  2. Fimmel S & Zouboulis CC. Comorbidities of hidradenitis suppurativa (acne inversa). Dermatoendocrinol 2010; 2: 9–16.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Saunte DM et al. Diagnostic Delay in Hidradenitis Suppurativa is a Global Problem. Br J Dermatol 2015; doi: 10.1111/bjd.14038

  4. Alikhan A et al. Hidradenitis suppurativa: A comprehensive review. J Am Acad Dermatol 2009, 60: 539–61

    Article  PubMed  Google Scholar 

  5. von der Werth JM et al. The clinical genetics of hidradenitis. Br J Dermatol 2002; 142: 947–53

    Article  Google Scholar 

  6. Yu CC. Hidradenitis suppurativa:a disease of follicular epithelium, rather than apocrine glands. Br J Dermatol 1990; 122: 763–9

    Article  CAS  PubMed  Google Scholar 

  7. von Laffert M et al. Hidradenitis suppurativa (acne inversa): early inflammatory events at terminal follicles and at interfollicular epidermis. Exp Dermatol 2010; 19: 533–7

    Article  Google Scholar 

  8. Kurzen H et al. What causes hidradenitis suppurativa? Exp Dermatol 2008; 17: 455–72

    Article  CAS  PubMed  Google Scholar 

  9. Kirschke JH et al. Hidradenitis suppurativa/Acne inversa, Ein Update. Hautarzt 2015; 66: 413–22

    Article  CAS  PubMed  Google Scholar 

  10. Zouboulis CC et al. Hidradenitis suppurativa / Acne inversa: Aktuelles zur Definition, Epidemiologie, Pathogenese, Klassifikation und Evidenz-basierten Therapie. Akt Dermatol 2015; 45: 185–99

    Google Scholar 

  11. Schrader AM et al. Hidradenitis suppurativa: A retrospective study of 846 Dutch patients to identify factors associated with disease severity. J Am Acad Dermatol 2014; 71: 460–7

    Article  PubMed  Google Scholar 

  12. Canoui-Poitrine F et al. Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity. Am Acad Dermatol 2009; 61: 51–7

    Article  Google Scholar 

  13. Hurley H. Axillary hyperhidrosis, apocrine bromhidrosis, hidradenitis suppurativa and familial benign pemphigus. Surgical approach. Dermatologic Surgery. Principles and Practice (Roenigk RK, Roenigk HH Jr, eds) 2nd edn. New York 1996

  14. Constantinou C et al. Hidradenitis suppurativa complicated by squamous cell carcinoma. Am Surg 2008; 74: 1177–81

    PubMed  Google Scholar 

  15. Zouboulis CC et al. Hidradenitis suppurativa/acne inversa: Criteria for diagnosis, severity assessment, classification and disease evaluation. Dermatology 2015; 231: 184–90

    Article  PubMed  Google Scholar 

  16. Zouboulis C et al. S1-Leitlinie zur Therapie der Hidradenitis suppurativa/Acne inversa. JDDG 2012; 10: 1–31

    Article  PubMed  Google Scholar 

  17. van Rappard DC et al. Mild to moderate hidradenitis suppurativa treated with local excision and primary closure. J Eur Acad Dermatol Venereol 2012; 26: 898–902

    Article  PubMed  Google Scholar 

  18. van Hattem S et al. Surgical treatment of sinuses by deroofing in hidradenitis suppurativa. Dermatol Surg 2012; 38: 494–7

    Article  PubMed  Google Scholar 

  19. Mizukami T et al. Reconstruction for extensive groin hidradenitis suppurativa using a combination of inferior abdominal flap and medial thigh-lift: a case report. Aesthetic Plast Surg 2014; 38: 745–8

    Article  PubMed  Google Scholar 

  20. Rompel R et al. Long-term results of wide surgical excision in 106 patients with hidradenitis suppurativa. Dermatol Surg 2000; 26: 638–43

    Article  CAS  PubMed  Google Scholar 

  21. Ritz JP et al. Extent of surgery and recurrence rate of hidradenitis suppurativa. Int J Colorect Dis 1998; 13: 164–8

    Article  CAS  Google Scholar 

  22. Harrison BJ et al. Recurrence after surgical treatment of hidradenitis suppurativa. Br Med J 1987; 294: 487–9

    Article  CAS  Google Scholar 

  23. Ulrich A et al. Acne inversa, Einfluss assoziierter Faktoren auf den Schweregrad und das operative Ergebnis. Hautarzt 2014; 65: 623–7

    Article  CAS  PubMed  Google Scholar 

  24. Lapins J et al. Scanner-assisted carbon dioxide laser surgery: a retrospective follow-up study of patients with hidradenitis suppurativa. J Am Acad Dermatol 2002; 47: 280–5

    Article  PubMed  Google Scholar 

  25. Clemmensen O et al. Topical treatment of hidradenitis suppurativa with clindamycin. Int J Dermatol 1983; 22: 325–8

    Article  CAS  PubMed  Google Scholar 

  26. van der Zee HH et al. The effect of combined treatment with oral clindamycin and oral rifampicin in patients with hidradenitis suppurativa. Dermatology 2009; 219: 143–7

    Article  PubMed  Google Scholar 

  27. Mendonça CO & Griffiths CE. Clindamycin and rifampicin combination therapy for hidradenitis suppurativa. Br J Dermatol 2006; 154: 977–8

    Article  PubMed  Google Scholar 

  28. Gener G et al. Combination therapy with clindamycin and rifampicin for hidradenitis suppurativa: a series of 116 consecutive patients. Dermatology 2009; 219: 148–54

    Article  CAS  PubMed  Google Scholar 

  29. Jemec GB. Efficacy and Safety of Adalimumab in patients with moderate to severe hidradenitis suppurativa: Results from PIONEER II, a Phase 3, randomized, placebo-controlled trial. Amsterdam: 23rd congress of the EADV, 2014

  30. Grant AG et al. Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial. J Am Acad Dermatol 2010; 62: 205–17

    Article  CAS  PubMed  Google Scholar 

  31. van Rappard DC et al. Comparing treatment outcome of infliximab and adalimumab in patients with severe hidradenitis suppurativa. J Dermatolog Treat 2012; 23: 284–9

    Article  PubMed  Google Scholar 

  32. Adams DR et al. Treatment of hidradenitis suppurativa with etanercept injection. Arch Dermatol 2010; 146: 501–4

    CAS  PubMed  Google Scholar 

  33. Kraft J et al. Hidradenitis suppurativa in 64 female patients: retrospective study comparing oral antibiotics and antiandrogen therapy. J Cutan Med Surg 2007; 11: 125–31

    Article  CAS  PubMed  Google Scholar 

  34. Brocard A et al. Hidradenitis suppurativa and zinc: a new therapeutic approach. A pilot study. Dermatology 2007; 214: 325–7

    Article  CAS  PubMed  Google Scholar 

  35. Soria A et al. Absence of efficacy of oral isotretinoin in hidradenitis suppurativa: a retrospective study based on patients’ outcome assessment. Dermatology 2009; 218: 134–5

    Article  CAS  PubMed  Google Scholar 

  36. Matusiak L et al. Acitretin treatment for hidradenitis suppurativa: a prospective series of 17 patients. Br J Dermatol 2014; 171: 170–4

    Article  CAS  PubMed  Google Scholar 

  37. Boer J et al. Long-term results of acitretin therapy for hidradenitis suppurativa. Is acne inversa also a misnomer? Br J Dermatol 2011; 164: 170–5

    Article  CAS  PubMed  Google Scholar 

  38. Kaur MR et al. Hidradenitis suppurativa treated with dapsone: A case series of five patients. J Dermatolog Treat 2006; 17: 211–3

    Article  CAS  PubMed  Google Scholar 

  39. Yazdanyar S et al. Dapsone therapy for hidradenitis suppurativa: a series of 24 patients. Dermatology 2011; 222: 342–6

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Klinik für Dermatologie, Klinikum Frankfurt (Oder), Müllroser Chaussee 7, 15236, Frankfurt (Oder), Deutschland

    Antonia Brandt &  Annett Milling

  2. Klinik für Dermatologie, Venerologie und Allergologie, Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau-Roßlau, Deutschland

    Christos C. Zouboulis

Authors
  1. Antonia Brandt
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  2. Annett Milling
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  3. Christos C. Zouboulis
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Correspondence to Annett Milling.

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Interessenkonflikt

Die Autoren erklären, dass sie sich bei der Erstellung des Beitrages von keinen wirtschaftlichen Interessen leiten ließen. Antonia Brandt erklärt, dass keine potenziellen Interessenkonflikte vorliegen. Annett Milling erklärt eine Beratungstätigkeit für AbbVie. Christos Zouboulis erklärt die Durchführung von klinischen Studien, die von der Firma AbbVie finanziert werden, eine Beratungs- und Vortragstätigkeit für AbbVie sowie die Durchführung einer klinischen Studie, die von der Firma Novartis finanziert wird. Der Verlag erklärt, dass die inhaltliche Qualität des Beitrags von zwei unabhängigen Gutachtern geprüft wurde. Werbung in dieser Zeitschriftenausgabe hat keinen Bezug zur CME-Fortbildung. Der Verlag garantiert, dass die CME-Fortbildung sowie die CME-Fragen frei sind von werblichen Aussagen und keinerlei Produktempfehlungen enthalten. Dies gilt insbesondere für Präparate, die zur Therapie des dargestellten Krankheitsbildes geeignet sind.

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Brandt, A., Milling, A. & Zouboulis, C.C. Langwierige Diagnose, hohe Rezidivrate. hautnah dermatologie 31, 40–47 (2015). https://doi.org/10.1007/s15012-015-1864-2

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  • DOI: https://doi.org/10.1007/s15012-015-1864-2

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