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Relationship between Helicobacter pylori and undifferentiated non-granulomatous anterior uveitis

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Abstract

Purpose

The relationship of Helicobacter pylori infection with ocular diseases, including anterior uveitis, has been reported. The objective of this study was to determine the presence of anti-H. pylori IgG antibodies in patients with idiopathic non-granulomatous anterior uveitis and compare the results with a control group.

Methods

A prospective, comparative, and cross-sectional study was conducted. Patients with idiopathic granulomatous anterior uveitis and a group of control subjects were included. The presence of anti-H. pylori IgG antibodies was determined. The chi-square test was performed for comparative analysis with GraphPad Prism V5.0 software.

Results

Thirty patients with idiopathic non-granulomatous anterior uveitis and 35 control subjects were included. In the determination of anti-H. pylori IgG antibodies, 24 (80%) patients and 19 (54%) control subjects were positive. A significant difference (p = 0.0263) was found between the groups and an odds ratio (OR) of 3.37.

Conclusions

A direct relationship was found between the presence of anti-H. pylori IgG antibodies and idiopathic non-granulomatous anterior uveitis. An association can be established between idiopathic non-granulomatous anterior uveitis and H. pylori infection, without this being a causal or physiopathogenic relationship.

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Data availability

The data generated in this research is available if necessary and upon reasonable request to the corresponding author.

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Funding

All authors declare to have no funding sources.

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Authors and Affiliations

  1. Centro de Investigación Biomédica, Fundación Hospital Nuestra Señora de la Luz I.A.P., Ezequiel Montes 135, Col. Tabacalera, C.P. 06030, Del. Cuauhtémoc, CDMX, México

    Héctor Javier Pérez-Cano, Jimena Ceja-Martínez, Vanessa Tellezgiron-Lara, Oscar Morales-López & Selma Alin Somilleda-Ventura

  2. Segmento Anterior, Fundación Hospital Nuestra Señora de la Luz I.A.P., Ezequiel Montes 135, Col. Tabacalera, C.P. 06030, Del. Cuauhtémoc, CDMX, México

    Jimena Ceja-Martínez

  3. Uvea y Enfermedades Inflamatorias, Fundación Hospital Nuestra Señora de la Luz I.A.P., Ezequiel Montes 135, Col. Tabacalera, C.P. 06030, Del. Cuauhtémoc, CDMX, México

    Stephanie Voorduin-Ramos

Authors
  1. Héctor Javier Pérez-Cano
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  2. Jimena Ceja-Martínez
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  3. Vanessa Tellezgiron-Lara
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  5. Oscar Morales-López
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  6. Selma Alin Somilleda-Ventura
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Contributions

HJP-C and SAS-V contributed equally. HJP-C, SAS-V, SV-R, JC-M, VT-L, and OM-L designed the study. ASS-V and HJP-C were responsible for the statistical analysis. All of the authors contributed to patient enrollment, data collection, and interpretation. All of the authors approved the final version of the manuscript.

Corresponding author

Correspondence to Héctor Javier Pérez-Cano.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical standards

This study was performed following the Declaration of Helsinki. Informed consent was obtained from the participants. Local ethics authorities revised the project design and granted approval for the study (2016U4R2).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

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Authors in the article are all agreed to the submission of this article for publication.

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Pérez-Cano, H.J., Ceja-Martínez, J., Tellezgiron-Lara, V. et al. Relationship between Helicobacter pylori and undifferentiated non-granulomatous anterior uveitis. Infection 51, 765–768 (2023). https://doi.org/10.1007/s15010-022-01970-0

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  • DOI: https://doi.org/10.1007/s15010-022-01970-0

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