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Observed transaminitis with a unique bacteriophage therapy protocol to treat recalcitrant Staphylococcal biofilm infections

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References

  1. Doub JB. Bacteriophage therapy for clinical biofilm infections: parameters that influence treatment protocols and current treatment approaches. Antibiotics (Basel). 2020;9:799.

    Article  CAS  Google Scholar 

  2. Dąbrowska K. Phage therapy: What factors shape phage pharmacokinetics and bioavailability? systematic and critical review. Med Res Rev. 2019;39:2000–25.

    Article  Google Scholar 

  3. Aslam S, Lampley E, Wooten D, Karris M, Benson C, Strathdee S, Schooley R. Lessons learned from the first 10 consecutive cases of intravenous bacteriophage therapy to treat multidrug-resistant bacterial infections at a single center in the United States. Open Forum Infect Dis. 2020;7:389.

    Article  Google Scholar 

  4. Onsea J, Soentjens P, Djebara S, Merabishvili M, Depypere M, Spriet I, De Munter P, Debaveye Y, Nijs S, Vanderschot P, Wagemans J, Pirnay JP, Lavigne R, Metsemakers WJ. Bacteriophage application for difficult-to-treat musculoskeletal infections: development of a standardized multidisciplinary treatment protocol. Viruses. 2019;11:891.

    Article  CAS  Google Scholar 

  5. Chang RYK, Wallin M, Lin Y, Leung SSY, Wang H, Morales S, Chan HK. Phage therapy for respiratory infections. Adv Drug Deliv Rev. 2018;133:76–86.

    Article  CAS  Google Scholar 

  6. Ferry T, Kolenda C, Batailler C, Gustave CA, Lustig S, Malatray M, et al. Phage therapy as adjuvant to conservative surgery and antibiotics to salvage patients with relapsing S. aureus prosthetic knee infection. Front Med. 2020;7:570572.

    Article  Google Scholar 

  7. Doub JB, Ng VY, Johnson AJ, Slomka M, Fackler J, Horne B, Brownstein MJ, Henry M, Malagon F, Biswas B. Salvage bacteriophage therapy for a chronic MRSA prosthetic joint infection. Antibiotics (Basel). 2020;9:241.

    Article  Google Scholar 

  8. Hansen MF, Svenningsen SL, Røder HL, Middelboe M, Burmølle M. Big impact of the tiny: bacteriophage-bacteria interactions in biofilms. Trends Microbiol. 2019;27:739–52.

    Article  CAS  Google Scholar 

  9. Roy ME, Peppers MP, Whiteside LA, Lazear RM. Vancomycin concentration in synovial fluid: direct injection into the knee vs. intravenous infusion. J Arthroplasty. 2014;29:564–8.

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Clinical Care and Research, Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA

    James B. Doub & Eleanor Wilson

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  1. James B. Doub
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  2. Eleanor Wilson
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Correspondence to James B. Doub.

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None to declare.

Ethical approval

All patients gave informed consent to be administered bacteriophage therapy for their recalcitrant infections and to publish their cases and/or data. All patients included had individual IND’s granted by the FDA through the expanded access pathway. These were individually reviewed and approved by the University of Maryland IRB.

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Doub, J.B., Wilson, E. Observed transaminitis with a unique bacteriophage therapy protocol to treat recalcitrant Staphylococcal biofilm infections. Infection 50, 281–283 (2022). https://doi.org/10.1007/s15010-021-01675-w

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  • DOI: https://doi.org/10.1007/s15010-021-01675-w

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