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Admission lysophosphatidylethanolamine acyltransferase level predicts the severity and prognosis of community-acquired pneumonia

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Abstract

Purpose

Early diagnosis and prognosis of patients with community-acquired pneumonia (CAP) are still difficult clinical challenges. This study aimed to investigate the role of lysophosphatidylethanolamine acyltransferase (LPEAT) in CAP and to evaluate the effectiveness of this enzyme as an indicator of disease severity and risk of death in CAP.

Methods

This retrospective, multi-center study was conducted in 2017. A total of 267 patients with CAP were included. Of these 267 patients, 175 patients had non-severe CAP (non-SCAP) and 92 patients had severe CAP (SCAP). In addition, we recruited 15 healthy volunteers and 42 hospitalized disease controls in our study. The demographic and clinical characteristics were recorded for all participants. Admission levels of LPEAT were determined by quantitative enzyme-linked immunosorbent assay.

Results

Admission levels of LPEAT in patients with SCAP were significantly higher, particularly in non-survivors and were not affected by the causative etiology. Furthermore, when the patients were stratified according to PSI and CURB-65 scores, the patients with high severity scores had higher LPEAT levels upon admission than patients with low severity scores. LPEAT also performed well in predicting SCAP in patients with CAP. Moreover, LPEAT could predict the 30-day mortality rate of patients with CAP, and combining LPEAT with the clinical severity score further improved the accuracy of mortality prediction.

Conclusion

Elevated LPEAT levels can reliably predict the severity of illness in patients with CAP at the time of admission. Adding LPEAT to clinical scoring methods could improve prognostic accuracy.

Trial registration

ClinicalTrials.gov, NCT03093220. Registered on March 28th, 2017.

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Acknowledgements

The authors thank all patients who participated in the study. This study was funded by the Ministry of Science and Technology of China (2017ZX10103004-006). The authors thank all patients who participated in the study.

Funding

This study was funded by the Ministry of Science and Technology of China (2017ZX10103004-006).

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Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing, China

    Li Chen, Lili Zhao, Ying Shang, Yu Xu & Zhancheng Gao

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  1. Li Chen
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  2. Lili Zhao
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  3. Ying Shang
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  4. Yu Xu
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Contributions

LC: writing (original draft, then review and editing) and data curation. LZ: writing (review and editing). YS: writing (review and editing) and data curation. YX: writing (review and editing) and funding acquisition. ZG: writing (review and editing) and conceptualization.

Corresponding authors

Correspondence to Yu Xu or Zhancheng Gao.

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Conflict of interest

On behalf of all the authors, the corresponding author states that there is no conflict of interest. All the authors declare that the submitted work has not been published before (neither in English nor in any other language) and that the work is not under consideration for publication elsewhere.

Ethics approval

The study was approved by the Institutional Review Board of PKUPH (No. 2016PHB202-01).

Consent to participate

Informed written consent was obtained from all participants in this study.

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All the authors read the manuscript and approved the submission.

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Chen, L., Zhao, L., Shang, Y. et al. Admission lysophosphatidylethanolamine acyltransferase level predicts the severity and prognosis of community-acquired pneumonia. Infection 49, 877–888 (2021). https://doi.org/10.1007/s15010-021-01585-x

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  • DOI: https://doi.org/10.1007/s15010-021-01585-x

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