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Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review

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Abstract

Purpose

There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms.

Methods

We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment options for XDR NDM-producing Enterobacteriaceae.

Results

Infections caused by New Delhi beta-lactamase (NDM)-producing Enterobacteriaceae are becoming increasingly prevalent worldwide. The presence of the enzyme results in multidrug-resistant and extensively drug-resistant phenotypes which often pose a treatment challenge. Despite this challenge, case reports and series have demonstrated good clinical outcomes with numerous treatment options in comparison to infections due to KPC-producing Enterobacteriaceae.

Conclusions

Further good-quality research focused on the treatment of NDM-producing Enterobacteriaceae is warranted.

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Authors and Affiliations

  1. Microbiology Laboratory, National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

    Vindana Chibabhai, Trusha Nana & Norma Bosman

  2. Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Vindana Chibabhai, Trusha Nana, Norma Bosman, Teena Thomas & Warren Lowman

  3. Infection Control Services, National Health Laboratory Service, Charlotte Maxeke Johannesburg Academic Hospital, Johannesburg, South Africa

    Teena Thomas

  4. Vermaak and Partners Pathologists, Wits Donald Gordon Medical Centre, Johannesburg, South Africa

    Warren Lowman

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  1. Vindana Chibabhai
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Chibabhai, V., Nana, T., Bosman, N. et al. Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review. Infection 46, 1–13 (2018). https://doi.org/10.1007/s15010-017-1070-8

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