Skip to main content

Advertisement

SpringerLink
Log in

Fatal Neisseria macacae infective endocarditis: first report

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

Introduction

Neisseria macacae is a Gram-negative diplococcus, found in the oropharynx of healthy Rhesus Monkeys. Infections caused by N. macacae in humans are extremely rare.

Case presentation

We present here the first case of N. macacae infective endocarditis in a 65-year-old man with a native aortic valve infection complicated by a peri-aortic abscess. N. macacae was isolated from blood culture and was found on the cardiac valve using 16S rDNA detection. Despite an appropriate antibiotic therapy, and aortic homograft replacement, and mitral repair, the patient died 4 days after surgery from a massive hemorrhagic stroke.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Vedros NA, Hoke C, Chun P. Neisseria macacae sp. nov., a new Neisseria species isolated from the oropharynges of Rhesus Monkeys (Macaca mulatta). Int J Syst Bacteriol. 1983;33:515–20.

    Article  Google Scholar 

  2. Weyand NJ, Wertheimer AM, Hobbs TR, Sisko JL, Taku NA, Gregston LD, et al. Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence, and horizontal gene transfer. Proc Natl Acad Sci USA. 2013;19:3059–64.

    Article  Google Scholar 

  3. Bennett JS, Jolley KA, Earle SG, Corton C, Bentley SD, Parkhill J, et al. A genomic approach to bacterial taxonomy: an examination and proposed reclassification of species within the genus Neisseria. Microbiology. 2012;158:1570–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bennett JS, Jolley KA, Maiden MC. Genome sequence analyses show that Neisseria oralis is the same species as ‘Neisseria mucosa var. heidelbergensis’. Int J Syst Evol Microbiol. 2013;63:3920–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Schouten MA, Suwandy F, Quaak M. Neisseria macacae bacteraemia in a child with fever and petechiae. Ned Tijdschr Med Microbiol. 2014;S83–4.

  6. Mechergui A, Achour W, Hassen AB. Intraspecific 16S rRNA gene diversity among clinical isolates of Neisseria species. APMIS. 2014;122:437–42.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Alberto Riberi who managed the patient in surgery, Hajer Graier, Hervé Chaudet, and Sophie Edouard for technical help, and Magdalen Lardière for English corrections.

Author information

Authors and Affiliations

  1. Faculté de Médecine, URMITE, Aix-Marseille Université, UM63, CNRS 7278, IRD 198, INSERM 1095, IHU Méditerranée Infection, 19-21 Boulevard Jean Moulin, 13005, Marseille, France

    Maude Vecten, Jean-Paul Casalta, Hubert Lepidi, Didier Raoult & Frédérique Gouriet

  2. Pôle de Maladies Infectieuses, Hôpital de la Timone, Rue St Pierre, 13385, Marseille, France

    Maude Vecten, Jean-Paul Casalta, Didier Raoult & Frédérique Gouriet

  3. Department of Cardiology, Centre Hospitalier Universitaire, Hôpital de La Timone, AP-HM, Aix-Marseille University, Marseille, France

    Hélène Martel, Sandrine Hubert & Gilbert Habib

Authors
  1. Maude Vecten
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hélène Martel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jean-Paul Casalta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sandrine Hubert
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hubert Lepidi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Gilbert Habib
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Didier Raoult
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Frédérique Gouriet
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Frédérique Gouriet.

Ethics declarations

Conflict of interest

None.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vecten, M., Martel, H., Casalta, JP. et al. Fatal Neisseria macacae infective endocarditis: first report. Infection 45, 369–371 (2017). https://doi.org/10.1007/s15010-017-0985-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-017-0985-4

Keywords

Search

Navigation