Skip to main content

Advertisement

SpringerLink
Log in

Bilateral periprosthetic joint infection with Ureaplasma urealyticum in an immunocompromised patient

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

This case study discusses how we diagnosed and treated a patient with a late haematogenous bilateral periprosthetic joint infection (PJI) after total knee arthroplasties caused by Ureaplasma urealyticum. This has never been reported before. We will discuss how we used a PET-CT, synovial fluid cell count, and synovial fluid analysis by 16S rRNA gene sequencing to diagnose this PJI. We will also discuss how we treated this patient to obtain full recovery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Huotari K, Peltola M, Jämsen E. The incidence of late prosthetic joint infections: a registry-based study of 112,708 primary hip and knee replacements. Acta Orthop. 2015;86:321–5.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Gundtoft PH, Overgaard S, Schønheyder HC, Møller JK, Kjærsgaard-Andersen P, Pedersen AB. The “true” incidence of surgically treated deep prosthetic joint infection after 32,896 primary total hip arthroplasties: a prospective cohort study. Acta Orthop. 2015;86:326–34.

    Article  PubMed  PubMed Central  Google Scholar 

  3. J Parvizi, T Gehrke. In: Proceedings of the International Consensus Meeting on Periprosthetic Joint Infection. 2013. ISBN 978-1-57400-147-1.

  4. Kumar R, Kumar V, Malhotra R. Potential clinical implication of 18 F-FDG PET/CT in diagnosis of periprosthetic infection and its comparison with 18 F-Fluoride PET/CT. J Med Imaging Radiat Oncol. 2016. doi:10.1111/1754-9485.12444 (Epub ahead of print).

    Google Scholar 

  5. Basu S, Kwee TC, Saboury B, Garino JP, Nelson CL, Zhuang H, et al. FDG PET for diagnosing infection in hip and knee prostheses: prospective study in 221 prostheses and subgroup comparison with combined (111)In-labeled leukocyte/(99 m)Tc-sulfur colloid bone marrow imaging in 88 prostheses. Clin Nucl Med. 2014;39:609–15.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Bedair H, Ting N, Jacovides C, Saxena A, Moric M, Parvizi J, Della Valle CJ. The Mark Coventry Award: diagnosis of early postoperative TKA infection using synovial fluid analysis. Clin Orthop Relat Res. 2011;469:34–40.

    Article  PubMed  Google Scholar 

  7. Sköldenberg OG, Rysinska AD, Neander G, Muren OH, Ahl TE. Ureaplasma urealyticum infection in total hip arthroplasty leading to revision. J Arthroplasty. 2010;25:11–3.

    Article  Google Scholar 

  8. Dias JM, Costa MM, da Silva JAP, de Queiroz MV. Septic arthritis: patients with or without isolated infectious agents have similar characteristics. Infection. 2014;42:385–91.

    Article  Google Scholar 

  9. Lai GG, Lim ST, Tao M, Chan A, Li H, Quek R. Late-onset neutropenia following RCHOP chemotherapy in diffuse large B-cell lymphoma. Am J Hematol. 2009;84:414–7.

    Article  CAS  PubMed  Google Scholar 

  10. Boxer L. How to approach neutropenia. Hematol Educ Progr Am Soc Hematol. 2012;2012:174–82.

    Google Scholar 

  11. Presterl E, Grisold AJ, Reichmann S, Hirschl AM, Georgopoulos A, Graninger W. Viridans streptococci in endocarditis and neutropenic sepsis: biofilm formation and effects of antibiotics. J Antimicrob Chemother. 2005;55:45–50.

    Article  CAS  PubMed  Google Scholar 

  12. Tande A, Patel R. Prosthetic joint infection. Clin Microbiol Rev. 2014;27:302–45.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kado R, Sanders G, McCune WJ. Suppression of normal immune responses after treatment with rituximab. Curr Opin Rheumatol. 2016;28:251–8.

    Article  CAS  PubMed  Google Scholar 

  14. Filanovsky K, Miller EB, Sigler E, Berrebi A, Shvidel L. Incidence of profound hypogammaglobulinemia and infection rate in lymphoma patients following the combination of chemotherapy and rituximab. Recent Pat Anticancer Drug Discov. 2016;11:228–35.

    Article  CAS  PubMed  Google Scholar 

  15. Fried AJ, Bonilla FA. Pathogenesis, diagnosis, and management of primary antibody deficiencies and infections. Clin Microbiol Rev. 2009;22:396–414.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Achermann Y, Stasch P, Preiss S, Lucke K, Vogt M. Characteristics and treatment outcomes of 69 cases with early prosthetic joint infections of the hip and knee. Infection. 2014;42:511–9.

    Article  CAS  PubMed  Google Scholar 

  17. Samra Z, Rosenberg S, Dan M. Susceptibility of Ureaplasma urealyticum to tetracycline, doxycycline, erythromycin, roxithromycin, clarithromycin, azithromycin, levofloxacin and moxifloxacin. J Chemother. 2011;23:77–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jeroen Bosch Hospital, Henri Dunantstraat 1, 5223 GZ, ’s-Hertogenbosch, The Netherlands

    R. L. Roerdink, C. M. Douw, A. C. A. P. Leenders, R. S. Dekker, M. Dietvorst & L. P. A. Bom

  2. Catharinahospital, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands

    C. J. M. Oosterbos & R. W. T. M. Kempen

  3. Elisabeth-Tweesteden Hospital, Dr. Deelenlaan 5, 5042 AD, Tilburg, The Netherlands

    H. T. J. Roerdink

Authors
  1. R. L. Roerdink
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. M. Douw
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. C. A. P. Leenders
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. S. Dekker
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Dietvorst
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. J. M. Oosterbos
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H. T. J. Roerdink
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. R. W. T. M. Kempen
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. L. P. A. Bom
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. L. Roerdink.

Ethics declarations

Informed consent

The patient has given her informed consent prior to this report.

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Roerdink, R.L., Douw, C.M., Leenders, A.C.A.P. et al. Bilateral periprosthetic joint infection with Ureaplasma urealyticum in an immunocompromised patient. Infection 44, 807–810 (2016). https://doi.org/10.1007/s15010-016-0912-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-016-0912-0

Keywords

Search

Navigation