Skip to main content

Advertisement

Log in

Necrotizing mycosis due to Verruconis gallopava in an immunocompetent patient

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

Verruconis gallopava is a dematiaceous mould usually causing saprophytic infection in immunosuppressed host. Only a few cases have been published even in immunocompromised states. We present a rare case of pulmonary involvement in an immunocompetent patient with recurrent disease. The mid-aged woman had no evidence of any disease causing impaired immune response. Recurrent disease shows pulmonary infiltrates and symptoms of allergic bronchopulmonary mycosis. We describe an emerging pathogen that has been found in an immunocompetent host. Eradication was not possible despite the use of several different antifungal drugs. Further recurrence of infection in the described patient is probable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Shoham S, Pic-Aluas L, Taylor J, Cortez K, Rinaldi MG, Shea Y, Walsh TJ. Transplant-associated Ochroconis gallopava infections. Transpl Infect Dis. 2008;10:442–8.

    Article  CAS  PubMed  Google Scholar 

  2. Rossmann SN, Cernoch PL, Davis JR. Dematiaceous fungi are an increasing cause of human disease. Clin Infect Dis. 1996;22:73–80.

    Article  CAS  PubMed  Google Scholar 

  3. Singh N, Chang FY, Gayowski T, Marino IR. Infections due to dematiaceous fungi in organ transplant recipients: case report and review. Clin Infect Dis. 1997;24:369–74.

    Article  CAS  PubMed  Google Scholar 

  4. Meriden Z, Marr KA, Lederman HM, Illei PB, Villa K, Riedel S, Caroll KC, Zhang SX. Ochroconis gallopava infection in a patient with chronic granulomatous disease: case report and review of the literature. Med Mycol. 2012;50:883–9.

    Article  PubMed  Google Scholar 

  5. Mayer N, Bastani B. A case of pulmonary cavitary lesion due to Dactylaria constricta var. gallopava in a renal transplant patient. Nephrology. 2009;14:262.

    Article  PubMed  Google Scholar 

  6. Burns KEA, Ohori NP, Iacono AT. Dactylaria gallopava infection presenting as a pulmonary nodule in a single-lung transplant recipient. J Heart Lung Transplant. 2000;19:900–2.

    Article  CAS  PubMed  Google Scholar 

  7. Mancini MC, McGinnis MR. Dactylaria infection of a human being: pulmonary disease in a heart transplant recipient. J Heart Lung Transpl. 1992;11:827–30.

    CAS  Google Scholar 

  8. Wang TK, Chiu W, Chim S, Chan TM, Wong SS, Ho PL. Disseminated Ochroconis gallopavum infection in a renal transplant recipient: the first reported case and a review of the literature. Clin Nephrol. 2003;60:415–23. doi:10.5414/CNP60415.

    Article  CAS  PubMed  Google Scholar 

  9. Sides EH, Benson JD, Padhye AA. Phaeohyphomycotic brain abscess due to Ochroconis gallopavum in a patient with malignant lymphoma of a large cell type. J Med Vet Mycol. 1991;29:317–22.

    Article  PubMed  Google Scholar 

  10. Fukushima N, Mannen K, Okamoto S, Shinogi T, Nishimoto K, Sueoka E. Disseminated Ochroconis gallopavum infection in a chronic lymphocytic leukemia: a case report and review of the literature on hematological malignancies. Intern Med. 2005;44:879–82.

    Article  PubMed  Google Scholar 

  11. Qureshi ZA, Kwak EJ, Nguyen MH, Silveira FP. Ochroconis gallopava: a dematiaceous mold causing infections in transplant recipients. Clin Transplant. 2012;26:E17–23.

    Article  PubMed  Google Scholar 

  12. Odell JA, Alvarez S, Cvitkovich DG, Cortese DA, McComb BL. Multiple lung abscesses due to Ochroconis gallopavum, a dematiaceous fungus, in a nonimmunocompromised wood pulp worker. Chest. 2000;118:1503–5.

    Article  CAS  PubMed  Google Scholar 

  13. Hollingsworth JW, Shofer S, Zaas A. Successful treatment of Ochroconis gallopavum infection in an immunocompetent host. Infection. 2007;35:367–9.

    Article  CAS  PubMed  Google Scholar 

  14. Samerpitak K, Van der Linde E, Choi HJ, Gerrits van den Ende AHG, Machouart M, Gueidan C, de Hoog GS. Taxonomy of Ochroconis, genus including opportunistic pathogens on humans and animals. Fungal Divers. 2014;65:89–126. doi:10.1007/s13225-013-0253-6.

    Article  Google Scholar 

  15. Lass-Flörl C, Mayr A, Perkhofer S, Hinterberger G, Hausdorfer J, Speth C, Fille M. Activities of antifungal agents against yeasts and filamentous fungi: assessment according to the methodology of the European Committee on Antimicrobial Susceptibility Testing. Antimicrob Agents Chemother. 2008;52:3637–41. doi:10.1128/AAC.00662-08 [Epub 2008 Aug 11].

    Article  PubMed Central  PubMed  Google Scholar 

  16. Giraldo A, Sutton DA, Samerpitak K, de Hoog GS, Wiederhold NP, Guarro J, Gené J. Occurrence of Ochroconis and Verruconis species in clinical specimens from the United States. J Clin Microbiol. 2014;52:4189–201. doi:10.1128/JCM.02027-14 [Epub 2014 Sep 17].

    Article  PubMed Central  PubMed  Google Scholar 

  17. Seyedmousavi S, Samerpitak K, Rijs AJM, Melchers WJG, Mouton JW, Verweij PE, de Hoog GS. Antifungal Susceptibility Patterns of Opportunistic Fungi in the Genera Verruconis and Ochroconis. Antimicrob Agents Chemother. 2014;58:3285–92.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyian-nis DP, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, Van Burik JA, Wingard JR, Patterson TF. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:327–60.

    Article  CAS  PubMed  Google Scholar 

  19. Fricker-Hidalgo H, Coltey B, Llerena C, Renversez JC, Grillot R, Pin I, Pelloux H, Pinel C. Recombinant allergens combined with biological markers in the diagnosis of allergic bronchopulmonary aspergillosis in cystic fibrosis patients. Clin Vaccine Immunol. 2010;17:1330–6. doi:10.1128/CVI.00200-10.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

None for this case report.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christian Geltner.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Geltner, C., Sorschag, S., Willinger, B. et al. Necrotizing mycosis due to Verruconis gallopava in an immunocompetent patient. Infection 43, 743–746 (2015). https://doi.org/10.1007/s15010-015-0757-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-015-0757-y

Keywords

Navigation