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Predictive factors for extended-spectrum beta-lactamase producing Enterobacteriaceae causing infection among intensive care unit patients with prior colonization

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Abstract

We investigated the predictive factors for extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-PE) causing infections among intensive care unit patients with prior documented ESBL-PE colonization. Using multivariate analysis, referral from medical ward, nursing home or rehabilitation center [Odds ratio (OR), 2.5; 95 % confidence interval (CI), [1.3–5.0]; p = 0.007], previous fluoroquinolone treatment (OR, 3.4; CI, [1.1–10.5]; p = 0.003), extracorporeal membrane oxygenation (OR, 4.6; CI, [1.3–15.9]; p = 0.02), and absence of prior positive ESBL-PE rectal swab culture (OR, 5.0; CI, [1.6–10.0]; p = 0.0009) were risk factors for ESBL-PE infection. Easily identifiable factors may help with targeting carbapenem prescriptions.

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Acknowledgments

The authors would like to thank Mrs. Alison Good (Scotland, UK) for her helpful review of the manuscript.

Conflict of interest

All authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris-Diderot University, Paris, France

    D. Vodovar, N. Deye, F. J. Baud & B. Mégarbane

  2. Bacteriological Laboratory, Lariboisière Hospital, Paris-Diderot University, Paris, France

    G. Marcadé & L. Raskine

  3. Unit of Clinical Research, Lariboisière Hospital, Paris, France

    H. Rousseau & E. Vicaut

  4. INSERM U1144, Paris-Descartes University, Paris, France

    B. Mégarbane

Authors
  1. D. Vodovar
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  2. G. Marcadé
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  3. H. Rousseau
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  4. L. Raskine
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  5. E. Vicaut
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  6. N. Deye
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  7. F. J. Baud
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  8. B. Mégarbane
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Corresponding author

Correspondence to B. Mégarbane.

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Vodovar, D., Marcadé, G., Rousseau, H. et al. Predictive factors for extended-spectrum beta-lactamase producing Enterobacteriaceae causing infection among intensive care unit patients with prior colonization. Infection 42, 743–748 (2014). https://doi.org/10.1007/s15010-014-0619-z

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  • DOI: https://doi.org/10.1007/s15010-014-0619-z

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