, Volume 42, Issue 1, pp 191–194 | Cite as

Human infection by a “fish tapeworm”, Diphyllobothrium latum, in a non-endemic country

  • J. G. EstebanEmail author
  • C. Muñoz-Antoli
  • M. Borras
  • J. Colomina
  • R. Toledo
Case Report


We document a case of locally acquired “broad- or fish-tapeworm” infection caused by Diphyllobothrium latum in a 27-year-old Spanish man, confirmed by molecular analysis (COI gene). The patient had naturally expelled a worm of 110 cm in length, but the physical examination did not yield any remarkable findings, and the patient did not suffer from any particular symptoms. Laboratory test results were normal except for a remarkable increase in the red blood cell count, and an evident decrease in the mean corpuscular volume and mean corpuscular hemoglobin. Vitamin B12 and folic acid values were in the normal range without signs of anemia. It was suggested that these anomalies in erythrocyte formation might not be related to the parasite, and analysis of the patient’s anamnestic data revealed that the infection could only have been caused by the ingestion of imported fish, although no light could be shed on the specific source of infection. From a public health viewpoint, this human case of fish-borne zoonosis is exemplary, suggesting that not only is control of fish and fish product quality essential, but also increased awareness of the general population with regard to changes in culinary habits.


Fish tapeworm Diphyllobothrium latum Human infection Diphyllobothriasis 



We thank Dr. J. Sastre of Department of Physiology at the Faculty of Medicine at the University of Valencia for the helpful interpretation of the hematological results.

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.


  1. 1.
    Scholz T, Garcia HH, Kuchta R, Wicht B. Update on the human broad tapeworm (genus Diphyllobothrium), including clinical relevance. Clin Microbiol Rev. 2009;22:146–60.PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Wicht B, Peduzzi R, Yera H, Dupouy-Camet J. Diphyllobothrium. In: Dongyou L, editor. Molecular detection of human parasitic pathogens. Baton Rouge: CRC Press; 2012. p. 237–44.CrossRefGoogle Scholar
  3. 3.
    Chai JY, Murrell KD, Lymbery AJ. Fish-borne parasitic zoonoses: status and issues. Int J Parasitol. 2005;35:1233–54.PubMedCrossRefGoogle Scholar
  4. 4.
    Wicht B, Yanagida T, Scholz T, Ito A, Jimenez JA, Brabec J. Multiplex PCR for differential identification of broad tapeworms (Cestoda: Diphyllobothrium) infecting humans. J Clin Microbiol. 2010;48:3111–6.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Dupouy-Camet J, Peduzzi R. Current situation of human diphyllobothriasis in Europe. Euro Surveill. 2004;9:31–4.PubMedGoogle Scholar
  6. 6.
    Dick TA. Diphyllobothriasis: the Diphyllobothrium latum human infection conundrum and reconciliation with a worldwide zoonosis. In: Murrell KD, Fried B, editors. World class parasites: vol 11. Food-borne parasitic zoonoses. Fish and plant-borne parasites. New York: Springer SBM; 2007. p. 151–84.CrossRefGoogle Scholar
  7. 7.
    Yera H, Estran C, Delaunay P, Gari-Toussaint M, Dupouy-Camet J, Marty P. Putative Diphyllobothrium nihonkaiense acquired from a Pacific salmon (Oncorhynchus keta) eaten in France: genomic identification and case report. Parasitol Int. 2006;55:45–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Wicht B, de Marval F, Peduzzi R. Diphyllobothrium nihonkaiense (Yamane et al., 1986) in Switzerland: first molecular evidence and case reports. Parasitol Int. 1986;2007(56):195–9.Google Scholar
  9. 9.
    Wicht B, de Marval F, Gottstein B, Peduzzi R. Imported diphyllobothriasis in Switzerland: molecular evidence of Diphyllobothrium dendriticum (Nitzsch, 1824). Parasitol Res. 2008;102:201–4.PubMedCrossRefGoogle Scholar
  10. 10.
    Paugman A, Yera H, Poirier P, Lebuisson A, Dupouy-Camet J. Bothriocéphalose à Diphyllobothrium nihonkaiense: un nouveau risque lié à la consummation de saumon. Presse Méd. 2009;38:675–7.CrossRefGoogle Scholar
  11. 11.
    Shimizu H, Kawakatsu H, Shimizu T, Yamada M, Tegoshi T, Uchikawa R, Arizono N. Diphyllothriasis nihonkaiense: possibly acquired in Switzerland from imported Pacific salmon. Inter Med. 2008;47:1359–62.CrossRefGoogle Scholar
  12. 12.
    Zerolo FJ, Ibarra A, Escauriaza J, Ruiz P, Costan G. Diphyllobothrium latum: consideraciones a propósito de un caso en Córdoba. Enferm Infec. 1983;2:76–8.Google Scholar
  13. 13.
    Colomina J, Villar J, Esteban G. Parasitación asintomática por Diphyllobothrium latum en un niño español de 3 años. Med Clin (Barc). 2002;118:279.PubMedCrossRefGoogle Scholar
  14. 14.
    Gil-Setas A, Mazón A, Pascual P, Sagua H. Helmintiasis poco frecuente en nuestro medio en un varón de 71 años. Enferm Infecc Microbiol Clin. 2004;22:553–4.PubMedGoogle Scholar
  15. 15.
    Marty AM, Neafie RC. Diphyllobothriasis and sparganosis. In: Meyers WM, Neafie RC, Marty AM, Wear DJ, editors. Pathology of infectious diseases: vol I Helminthiases. Washington DC: Armed Forces Institute of Pathology, American Registry of Pathology; 2000. p. 165–83.Google Scholar
  16. 16.
    Organisation for Economic Cooperation and Development (OECD). Review of fisheries in OECD countries 2009. Policies and summary statistics. Capítulo 16, Spain. Paris: OECD; 2010; p. 237–44.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • J. G. Esteban
    • 1
    Email author
  • C. Muñoz-Antoli
    • 1
  • M. Borras
    • 2
  • J. Colomina
    • 2
  • R. Toledo
    • 1
  1. 1.Departamento de Parasitología, Facultad de FarmaciaUniversidad de ValenciaValenciaSpain
  2. 2.Servicio de MicrobiologíaHospital de La RiberaAlciraSpain

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