Abstract
Background
The intention of our investigation was to determine the seroprevalence of H1N1v antibodies after a pandemic by the haemagglutination inhibition (HI) test. We included the serum samples of adults who had not received vaccination against H1N1v. By means of serological footprints, the spread of infection can be investigated.
Materials and methods
Between December 2009 and May 2010, we collected 233 serum samples from healthy people aged 1–72 years and analysed the titres of H1N1v antibodies by the use of the HI test.
Results
After the pandemic, a seroprevalence of 36.9% was observed. The highest rate of seropositivity was detected in the age group of 10–19 years (60%) and the lowest rate was found in the age group of 30–39 years (22%). The seroprevalence of H1N1v antibodies in females exceeded the rate of positive men (41.5 vs. 31.8%). Almost 70% of the influenza A/H1N1v infections were passed inapparently.
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References
Taubenberger JK, Morens DM. The pathology of influenza virus infections. Annu Rev Pathol. 2008;3:499–522.
Palese P, Shaw ML. Orthomyxoviridae: the viruses and their replication. In: Knipe DM, Howley PM, editors. Fields virology. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. pp. 1647–90.
Obenauer JC, Denson J, Mehta PK, et al. Large-scale sequence analysis of avian influenza isolates. Science. 2006;311:1576–80.
Wright PF, Neumann G, Kawaoka Y. Orthomyxoviruses. In: Knipe DM, Howley PM, editors. Fields virology, 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2007. pp. 1691–740.
Michaelis M, Doerr HW, Cinatl J Jr. Novel swine-origin influenza A virus in humans: another pandemic knocking at the door. Med Microbiol Immunol. 2009;198(3):175–83.
Michaelis M, Doerr HW, Cinatl J Jr. An influenza A H1N1 virus revival—pandemic H1N1/09 virus. Infection. 2009;37(5):381–9.
Lagacé-Wiens PR, Rubinstein E, Gumel A. Influenza epidemiology—past, present, and future. Crit Care Med. 2010;38(4 Suppl):e1–9.
Allwinn R, Geiler J, Berger A, et al. Determination of serum antibodies against swine-origin influenza A virus H1N1/09 by immunofluorescence, haemagglutination inhibition, and by neutralization tests: how is the prevalence rate of protecting antibodies in humans? Med Microbiol Immunol. 2010;199(2):117–21.
Jones JH, Salathé M. Early assessment of anxiety and behavioral response to novel swine-origin influenza A(H1N1). PLoS One. 2009;4(12):e8032.
Buda S, Wilking H, Schweiger B, et al. Influenza-Wochenbericht. Der Arbeitsgemeinschaft Influenza. Robert Koch Institut für Kalenderwoche 8/2010. Available online at: http://www.influenza.rki.de/Wochenberichte/2009_2010/2010-08.pdf.
Taubenberger JK. The origin and virulence of the 1918 “Spanish” influenza virus. Proc Am Philos Soc. 2006;150(1):86–112.
Buda S, Wilking H, Schweiger B, et al. Influenza-Wochenbericht. Der Arbeitsgemeinschaft Influenza. Robert Koch Institut, Stand 27.04.2010.
Miller E, Hoschler K, Hardelid P, et al. Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study. Lancet. 2009;375(9720):1100–8.
Hancock K, Veguilla V, Lu X, et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med. 2009;361(20):1945–52.
Ross T, Zimmer S, Burke D, et al. Seroprevalence following the second wave of pandemic 2009 H1N1 influenza. PLoS Curr. 2010;2:RRN1148.
Statistisches Bundesamt Deutschland. Gesundheitszustand und gesundheitsrelevantes Verhalten.
Deimel H, Pfeifer K, Huber G, et al. Neue aktive Wege in Prävention und Rehabilitation. Köln: Deutscher Ärzte Verlag; 2007.
Doerr HW, Allwinn R, Cinatl J. Against the new H1N1 influenza (swine influenza): vaccinate or don’t vaccinate (all)? That is currently the question! Infection. 2009;37(5):379–80.
Statistisches Jahrbuch der Stadt Frankfurt am Main, Stand 31.12.2008.
Robert Koch Institut. Epidemiologisches Bulletin, Ausgabe 50/2010 (20.12.2010).
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Reinheimer, C., Allwinn, R. & Doerr, H.W. Limited prevalence of influenza A/H1N1v antibodies: footprints of the pandemic of 2010. Infection 39, 101–104 (2011). https://doi.org/10.1007/s15010-011-0105-9
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DOI: https://doi.org/10.1007/s15010-011-0105-9