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Femoral osteomyelitis due to Cladophialophora arxii in a patient with chronic granulomatous disease

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Abstract

Fungal infections in patients with chronic granulomatous disease (CGD) are a poor prognostic factor. We describe the first case of CGD with femoral osteomyelitis due to Cladophialophora arxii, which is a member of the dematiaceous group. The causative fungus was identified on the basis of its morphological characteristics, growth temperature profile, and nucleotide sequence on the internal transcribed space region of the ribosomal gene. The patient was successfully treated with surgical debridement, subsequent administration of itraconazolem and interferon-γ.

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Authors and Affiliations

  1. Dept. of Pediatrics, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    T. Shigemura, K. Agematsu, T. Yamazaki & K. Koike

  2. Dept. of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

    K. Eriko

  3. Dept. of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan

    G. Yasuda

  4. First Laboratories Co., Ltd., Medical Mycology Research Center, Chiba University, Chiba, Japan

    K. Nishimura

Authors
  1. T. Shigemura
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  2. K. Agematsu
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  3. T. Yamazaki
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  4. K. Eriko
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  5. G. Yasuda
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  6. K. Nishimura
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  7. K. Koike
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Correspondence to T. Shigemura.

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Shigemura, T., Agematsu, K., Yamazaki, T. et al. Femoral osteomyelitis due to Cladophialophora arxii in a patient with chronic granulomatous disease. Infection 37, 469–473 (2009). https://doi.org/10.1007/s15010-009-8238-9

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  • DOI: https://doi.org/10.1007/s15010-009-8238-9

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