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A Rare Case of Clostridium sordellii Bacteremia in an Immunocompromised Patient

Abstract

Clostridium sordellii is a gram-positive, anaerobic sporeforming rod with peritrichous flagella that is rarely associated with disease in humans. In most cases, infections occur after trauma, childbirth and routine gynecological procedures or intravenous drug abuse. C. sordellii produce several exotoxins that lead to progressive edema and shock, and C. sordellii infections have high mortality rates of up to 70%. Since its first report in 1922, only a few cases of bacteremia have been reported. This report describes a case of C. sordellii bacteremia in a patient with rectum carcinoma and liver metastases.

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References

  1. Abdulla A, Yee L: The clinical spectrum of Clostridium sordellii bacteraemia: two case reports and a review of the literature. J Clin Pathol 2000; 53: 709–712.

    PubMed  Article  CAS  Google Scholar 

  2. Wiebe E, Guilbert E, Jacot F, Shannon C, Winikoff B: A fatal case of Clostridium sordellii septic shock syndrome associated with medical abortion. Obstet Gynecol 2004; 104: 1142–1144.

    PubMed  Google Scholar 

  3. Centers for Disease Control and Prevention (CDC): Clostridium sordellii toxic shock syndrome after medical abortion with mifepristone and intravaginal misoprostol - United States and Canada, 2001-2005. MMWR Morb Mortal Wkly Rep, 2005: 724.

  4. Fischer M, Bhatnagar J, Guarner J, Reagan S, Hacker JK, Van Meter SH, Poukens V, Whiteman DB, Iton A, Cheung M, Dassey DE, Shieh WJ, Zaki SR: Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortion. N Engl J Med 2005; 353: 2352–2360.

    PubMed  Article  CAS  Google Scholar 

  5. Elsayed S, Zhang K: Positive Clostridium difficile stool assay in a patient with fatal Clostridium sordellii infection. N Engl J Med 2006; 355: 1284–1285.

    PubMed  Article  CAS  Google Scholar 

  6. Aldape MJ, Bryant AE, Stevens DL: Clostridium sordellii infection: epidemiology, clinical findings, and current perspectives on diagnosis and treatment. Clin Infect Dis 2006; 43: 1436–1446.

    PubMed  Article  CAS  Google Scholar 

  7. Aldape MJ, Bryant AE, Ma Y, Stevens DL: The leukemoid reaction in Clostridium sordellii infection: neuraminidase induction of promyelocytic cell proliferation. J Infect Dis 2007; 195: 1838–1845.

    PubMed  Article  CAS  Google Scholar 

  8. Foroulis CN, Gerogianni I, Kouritas VK, Karestsi E, Klapsa D, Gourgoulianis K, Petinaki E: Direct detection of Clostridium sordellii in pleural fluid of a patient with pneumonic empyema by a broad-range 16S rRNA PCR. Scand J Infect Dis 2007; 39: 617–619.

    PubMed  Article  CAS  Google Scholar 

  9. Spera RV Jr, Kaplan MH, Allen SL: Clostridium sordellii bacteremia: case report and review. Clin Infect Dis 1992; 15: 950–954.

    PubMed  Google Scholar 

  10. Martinez RD, Wilkins TD: Purification and characterization of Clostridium sordellii hemorrhagic toxin and cross-reactivity with Clostridium difficile toxin A (enterotoxin). Infect Immun 1988; 56: 1215–1221.

    PubMed  CAS  Google Scholar 

  11. Kikuchi E, Miyamoto Y, Narushima S, Itoh K: Design of species-specific primers to identify 13 species of Clostridium harbored in human intestinal tracts. Microbiol Immunol 2002; 46: 353–358.

    PubMed  CAS  Google Scholar 

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Correspondence to J. Matten.

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Matten, J., Buechner, V. & Schwarz, R. A Rare Case of Clostridium sordellii Bacteremia in an Immunocompromised Patient. Infection 37, 368–369 (2009). https://doi.org/10.1007/s15010-008-8192-y

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  • DOI: https://doi.org/10.1007/s15010-008-8192-y

Keywords

  • Clostridium
  • Teicoplanin
  • Tigecycline
  • Mifepristone
  • Toxic Shock Syndrome