Skip to main content

Advertisement

Log in

Detection of Herpesvirus DNA in Cerebrospinal Fluid and Correlation with Clinical Symptoms

  • Brief Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

Background:

Novel PCR techniques can detect minute quantities of herpesvirus DNA in cerebrospinal fluid (CSF). The clinical significance of such findings is not always clear.

Patients and Methods:

(a) Investigation of clinical characteristics of 76 patients with herpesvirus DNA detection in CSF. (b) Screening for herpesvirus DNA in CSF samples of 208 patients without clinical signs of herpesvirus infection.

Results:

(a) Eleven of 76 herpesvirus-DNA-positive patients did not show symptoms usually associated with the detected virus (HSV-1/2, n = 5; EBV, n = 6). (b) Two of 208 patients without hint for herpesvirus infection had HHV-6 DNA of low concentration in CSF.

Conclusions:

The detection of low-level herpesvirus replication in CSF by highly sensitive PCR assays requires critical evaluation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

We’re sorry, something doesn't seem to be working properly.

Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Plentz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Plentz, A., Jilg, W., Kochanowski, B. et al. Detection of Herpesvirus DNA in Cerebrospinal Fluid and Correlation with Clinical Symptoms. Infection 36, 158–162 (2008). https://doi.org/10.1007/s15010-007-6354-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-007-6354-y

Keywords

Navigation