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Chronic Hepatitis C: Viral Clearance Several Months after Discontinuation of Therapy in Two Non-responders

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Abstract

When hepatitis C virus (HCV) infection becomes chronic, spontaneous viral eradication is a rare event. We report two patients with chronic hepatitis C, non-responders to standard interferon alone. They were treated with Pegylated interferon plus ribavirin. At the end of therapy, HCV RNA was still detectable. Several months after stopping treatment, aminotransferase level normalized and HCV RNA became undetectable. No case of sustained viral response happening several months after therapy has been yet described. During long-term follow-up of non-responders, when a persistent normalization of aminotransferase level is observed after stopping treatment, viral clearance could be suspected.

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Authors and Affiliations

  1. Service d’Hépato-Gastroenterologie, Centre Hospitalier Sud-Francilien, quartier du Canal-Courcouronnes, 91014, Evry Cedex, France

    J. Denis, P. E. Rautou, B. Lambare & S. Herbert

  2. Service d’Hépato-Gastroentérologie, Centre Hospitalier Intercommunal, Créteil, France

    V. Auray-Cartier

  3. Service d’Hépatologie and INSERM CRB3, University of Paris VII, AP-HP, Hôpital Beaujon, Clichy, France

    T. Asselah

Authors
  1. J. Denis
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  2. P. E. Rautou
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  3. B. Lambare
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  4. S. Herbert
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  5. V. Auray-Cartier
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  6. T. Asselah
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Corresponding author

Correspondence to P. E. Rautou.

Additional information

ANGH Association Nationale des Gastro-entérologues des Hôpitaux non universitaires, Montfermeil, France

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Denis, J., Rautou, P.E., Lambare, B. et al. Chronic Hepatitis C: Viral Clearance Several Months after Discontinuation of Therapy in Two Non-responders. Infection 35, 197 (2007). https://doi.org/10.1007/s15010-007-6099-7

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  • DOI: https://doi.org/10.1007/s15010-007-6099-7

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