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Breakthrough Invasive Infection Due to Debaryomyces hansenii (teleomorph Candida famata) and Scopulariopsis brevicaulis in a Stem Cell Transplant Patient Receiving Liposomal Amphotericin B and Caspofungin for Suspected Aspergillosis

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Abstract

An allogeneic stem cell transplant recipient developed pulmonary infiltrates and Aspergillus antigenemia during prophylactic low–dose liposomal amphotericin B. No response to therapy was observed after increasing the dose of liposomal amphotericin B and addition of caspofungin, and breakthrough candidemia developed. Therapy switch to voriconazole did not prevent the development of lethal septic shock. Shortly before death, Scopulariopsis brevicaulis was cultured from bronchial secretions, and positive blood cultures demonstrated persistent candidemia due to Debaryomyces hansenii, teleomorph of Candida famata.

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Authors and Affiliations

  1. Center for Infectious Diseases and Travel Medicine, University Hospital, Hugstetter Str. 55, 79106, Freiburg, Germany

    D. Wagner & W. V. Kern

  2. Dept. of Medical Microbiology, University Hospital, Freiburg, Germany

    Anna Sander

  3. Dept. of Hematology-Oncology, University Hospital, Freiburg, Germany

    H. Bertz & J. Finke

Authors
  1. D. Wagner
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  2. Anna Sander
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  3. H. Bertz
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  4. J. Finke
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  5. W. V. Kern
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Corresponding author

Correspondence to W. V. Kern.

Additional information

This paper is dedicated to the founders of the Walter Marget Foundation, D. Adam and F. Daschner, in gratitude for their support of the training in infectious diseases.

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Wagner, D., Sander, A., Bertz, H. et al. Breakthrough Invasive Infection Due to Debaryomyces hansenii (teleomorph Candida famata) and Scopulariopsis brevicaulis in a Stem Cell Transplant Patient Receiving Liposomal Amphotericin B and Caspofungin for Suspected Aspergillosis. Infection 33, 397–400 (2005). https://doi.org/10.1007/s15010-005-5082-4

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  • DOI: https://doi.org/10.1007/s15010-005-5082-4

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