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Isolation of Dengue Virus Serotype 1 from the Blood of a Swiss Traveler Prior to Seroconversion

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Abstract

Dengue virus serotype 1 was isolated from the blood of a patient who had returned to Switzerland from Brazil with fever of unknown origin.

After 2 days of culture on Aedes albopictus (C6/36) cell line, the dengue virus was identified as serotype 1 using a type-specific indirect immunofluorescence assay. The diagnosis was confirmed by seroconversion of anti-dengue virus-specific IgM and IgG antibodies and by amplification of a serotype 1-specific region of the denque virus genome.

This is the first description of dengue virus isolation from the blood of a traveler returning to Switzerland. We recommend detection of dengue viremia during the 1st week of illness, before serological tests usually yield conclusive results, as the most efficient means of early specific diagnosis.

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Authors and Affiliations

  1. Institute for Clinical Microbiology and Immunology, Frohbergstr. 3, CH-9001 St. Gallen, Switzerland; Phone: (+41/71) 494-3700, Fax: -3705, e-mail: detlev.schultze@gd-ikmi.sg.ch, CH

    D. Schultze

  2. Dept. of Medicine, Kantonsspital, CH-9007 St. Gallen, Switzerland, CH

    C. Berendonk

  3. General Practioner, Leimatstr. 4, CH-9205 Waldkirch, Switzerland, CH

    T. Ammann

  4. Robert Koch Institute, Nordufer 20, D-13353 Berlin, Germany, DE

    M. Niedrig

Authors
  1. D. Schultze
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  2. C. Berendonk
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  3. T. Ammann
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  4. M. Niedrig
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Received: May 26, 2001 · Revision accepted: December 27, 2001

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Schultze, D., Berendonk, C., Ammann, T. et al. Isolation of Dengue Virus Serotype 1 from the Blood of a Swiss Traveler Prior to Seroconversion. Infection 30, 237–239 (2002). https://doi.org/10.1007/s15010-002-2091-4

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  • DOI: https://doi.org/10.1007/s15010-002-2091-4

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