Skip to main content

Advertisement

Log in

A Probable Case of Herpes simplex Encephalitis despite Negative PCR Findings Findings

  • Case Report
  • Published:
Infection Aims and scope Submit manuscript

Abstract

A 54-year-old woman was admitted to the hospital suffering from fever and personality changes. Laboratory examination of her cerebrospinal fluid (CSF) showed 270 mononuclear cells, 30 polynuclear cells and a clinically low number of erythrocytes/mm3. Empirical clinical findings from this case suggested treatment with acyclovir. Magnetic resonance imaging (MRI) showed bilateral temporal hyperintense signals in T2-weighted images. PCR with specific primer for herpes simplex virus type 1 (HSV-1) and HSV-2 were negative. There was no elevation of oligoclonal antibodies specific to HSV in CSF after 2 weeks. Although we did not prove the presence of the agent microbiologically at the clinical onset of the disease, the MRI and electroencephalogram (EEG) findings, erythrocytes in CSF and the dramatic response to acyclovir therapy are suggestive of a diagnosis of herpes simplex encephalitis (HSE).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: July 7, 2000 · Revision accepted: October 11, 2001

Rights and permissions

Reprints and permissions

About this article

Cite this article

Akhan, S., Coskunkan, F., Mutlu, B. et al. A Probable Case of Herpes simplex Encephalitis despite Negative PCR Findings Findings. Infection 29, 359–361 (2001). https://doi.org/10.1007/s15010-001-1095-9

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15010-001-1095-9

Navigation