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Der Farmeffekt revisited: vom β-Lactoglobulin mit Zink im Kuhstallstaub zur Anwendung

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Zusammenfassung

Hintergrund: Zahlreiche Faktoren wie Mikrobiota und deren Produkte werden im Zusammenhang mit der Hygienehypothese und dem damit assoziierten allergiepräventiven Farmeffekt diskutiert. Neben dem Einatmen der Stäube auf Bauernhöfen wirkt auch der Konsum von Rohmilch der Entstehung von Asthma und Allergien entgegen. Da besonders Rinderställe und Kuhmilch als wirksam beschrieben wurden, scheint die Beteiligung eines bovinen Proteins wahrscheinlich. β-Lactoglobulin (BLG) ist ein Hauptprotein in Milch und besitzt als Lipocalin eine intramolekulare Tasche, welche eine Bindung an hydrophobe Liganden ermöglicht.

Ergebnisse: Unsere Studien zeigen, dass unbeladenes BLG die Entstehung einer Allergie begünstigt, während beladenes, sogenanntes holo-BLG, allergiepräventiv wirkt. BLG konnte mit Zink assoziiert auch im Stallstaub und in der Umgebungsluft von Rinderfarmen nachgewiesen werden.

Schlussfolgerung: Es scheint daher naheliegend, dass zusätzlich zu Mikroben und deren Produkten auch holo-BLG eine wichtige Rolle im schützenden Farmeffekt spielt. In einer neu entwickelten Lutschtablette zum Diätmanagement bei Allergien ist Zink an holo-BLG daher, basierend auf dem Bauernhof-Effekt, einer der Schlüsselbestandteile.

Zitierweise: Mayerhofer H, Pali-Schöll I. The farm effect revisited: from β-lactoglobulin with zinc in cowshed dust to its application. Allergo J Int 2021; 30:135-40

https://doi.org/10.1007/s40629-021-00174-6

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Abb. 1

© Stall, Hütte: Clker-Free-Vector-Images@Pixabay; Kuh: grafikacesky@Pixabay; Alm, Mutter-Kind, Milch: OpenClipart-Vectors@Pixabay; Hund: Jose R. Cabello@Pixabay

Change history

  • 02 March 2022

    Zitationshinweise im Seitenkopf wurden entfernt, da sie zu Verwirrung bei der Zitationsdatenbank von Clarivate geführt haben.

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Mayerhofer H, Pali-Schöll I. The farm effect revisited: from β-lactoglobulin with zinc in cowshed dust to its application. Allergo J Int 2021; 30:135-40

https://doi.org/10.1007/s40629-021-00174-6

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Authors and Affiliations

  1. Interuniversitäres Messerli Forschungsinstitut, Veterinärmedizinische Universität Wien und Medizinische Universität Wien, Wien, Österreich

    Hanna Mayerhofer

  2. Institut für Pathophysiologie und Allergieforschung, Medizinische Universität Wien, Wien, Österreich

    Isabella Pali-Schöll

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  1. Hanna Mayerhofer
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  2. Isabella Pali-Schöll
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Correspondence to Isabella Pali-Schöll.

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Mayerhofer, H., Pali-Schöll, I. Der Farmeffekt revisited: vom β-Lactoglobulin mit Zink im Kuhstallstaub zur Anwendung. Allergo J 30, 44–49 (2021). https://doi.org/10.1007/s15007-021-4820-y

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