Es ist Aufgabe jedes Arztes, für einen guten Impfschutz seiner Patienten zu sorgen. Allergische Reaktionen auf Impfstoffe sind selten und sollten daher kein Anlass sein, einen Impfschutz zu verhindern. Wann eine allergologische Diagnostik notwendig ist und was es hinsichtlich Allergien und Impfungen zu beachten gilt, haben Sebastian Schmidt, Thomas Spindler und Tobias Ankermann in Kapitel 4.12 der Neuauflage des „Weißbuch Allergie in Deutschland“ zusammengefasst.
Literatur
www.erkenntnisweg.de/themen/impfen/impfen. pps [Zugriff am 30.8.2018].
www.tetanus-luege.de [Zugriff am 7.3. 2018]
Oberle D, Pavel J, Rieck T, Weichert S, Schroten H, Keller-Stanislawski B, et al. Anaphylaxis after immunization of children and adolescents in Germany. Ped Inf Dis J 2016;35:535–41
Bohlke K, Davis RL, Marcy SM, Braun MM, DeStefano F, Black SB, et al. Risk of anaphylaxis after vaccination of children and adolescents. Pediatrics 2003;112:815–20
McNeil M, Weintraub ES, Duffy J, Sukumaran L, Jacobsen SJ, Klein NP, et al. Risk of anaphylaxis after vaccination in children and adults. J Allergy Clin Immunol 2016;137:868–78
Rüggeberg JU, Gold MS, Bayas JM, Blum MD, Bonhoeffer J, Friedlander S, et al. Anaphylaxis: case definition and guidelines for data collection, analysis, and presentation of immunization safety data. Brighton Collaboration Anaphylaxis Working Group. Vaccine 2007;25:5675–8
Miller ER, Moro PL, Cano M, Shimabukuro TT. Deaths following vaccination: What does the evidence show?. Vaccine 2015;33:3288–92
Anaphylaxie-Register, gemeinsame Datenbank für Deutschland, Österreich und die Schweiz zur Erhebung aufgetretener anaphylaktischer Reaktionen; Stand 15.9.2017; www.anaphylaxie. Net
Pawankar R. Allergic diseases and asthma: a global public health concern and a call to action. World Allergy Organ J 2014;7:12
Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002;347:911–20
Ege MJ, Mayer M, Normand AC, et al. Exposure to environmental microorganisms and childhood asthma. N Engl J Med 2011;364:701–9
Ege MJ. The hygiene hypothesis in the age of the microbiome. Ann Am Thorac Soc 2017;14 (Suppl 5):S348–53
von Hertzen L, Beutler B, Bienenstock J, et al. Helsinki alert of biodiversity and health. Ann Med 2015;47:218–25
Grüber C, Nilsson L, Bjorksten B. Do early childhood immunizations influence the development of atopy and do they cause allergic reactions?. Pediatr Allergy Immunol 2001;12:296–311
Schlaud M, Schmitz R, Poethko-Muller C, Kuhnert R. Vaccinations in the first year of life and risk of atopic disease — Results from the KiGGS study. Vaccine 2017;35:5156–62
Asher MI, Stewart AW, Mallol J, et al. Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One. Respir Res 2010;11:8
Balicer RD, Grotto I, Mimouni M, Mimouni D. Is childhood vaccination associated with asthma? 4.12 Allergien und Impfungen 323 A meta-analysis of observational studies. Pediatrics 2007;120:e1269–77
Grüber C, Illi S, Lau S, et al. Transient suppression of atopy in early childhood is associated with high vaccination coverage. Pediatrics 2003;111:e282–8
Grüber C, Warner J, Hill D, Bauchau V. Early atopic disease and early childhood immunization — is there a link? Allergy 2008;63:1464–72
Koppen S, de Groot R, Neijens HJ, Nagelkerke N, van Eden W, Rumke HC. No epidemiological evidence for infant vaccinations to cause allergic disease. Vaccine 2004;22:3375–85
Maher JE, Mullooly JP, Drew L, DeStefano F. Infant vaccinations and childhood asthma among full-term infants. Pharmacoepidemiol Drug Saf 2004;13:1–9
Martignon G, Oryszczyn MP, Annesi-Maesano I. Does childhood immunization against infectious diseases protect from the development of atopic disease? Pediatr Allergy Immunol 2005;16:193–200
Matheson MC, Haydn Walters E, Burgess JA, et al. Childhood immunization and atopic disease into middle-age — a prospective cohort study. Pediatr Allergy Immunol 2010;21:301–6
McKeever TM, Lewis SA, Smith C, Hubbard R. Vaccination and allergic disease: a birth cohort study. Am J Public Health 2004;94:985–9
Spycher BD, Silverman M, Egger M, Zwahlen M, Kuehni CE. Routine vaccination against pertussis and the risk of childhood asthma: a population-based cohort study. Pediatrics 2009;123:944–50
Grabenhenrich LB, Gough H, Reich A, et al. Early-life determinants of asthma from birth to age 20 years: a German birth cohort study. J Allergy Clin Immunol 2014;133:979–88
Nilsson L, Gruber C, Granstrom M, Bjorksten B, Kjellman NI. Pertussis IgE and atopic disease. Allergy 1998;53:1195–201
Nilsson L, Kjellman NI, Bjorksten B. Allergic disease at the age of 7 years after pertussis vaccination in infancy: results from the follow-up of a randomized controlled trial of 3 vaccines. Arch Pediatr Adolesc Med 2003;157:1184–9
Vogt H, Braback L, Kling AM, Grunewald M, Nilsson L. Pertussis immunization in infancy and adolescent asthma medication. Pediatrics 2014;134:721–8
Bernsen RM, de Jongste JC, van der Wouden JC. Lower risk of atopic disorders in whole cell pertussis-vaccinated children. Eur Respir J 2003;22:962–4
Rosenlund H, Bergstrom A, Alm JS, et al. Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection. Pediatrics 2009;123:771–8
Hviid A, Melbye M. Measles-mumps-rubella vaccination and asthma-like disease in early childhood. Am J Epidemiol 2008;168:1277–83
Timmermann CA, Osuna CE, Steuerwald U, Weihe P, Poulsen LK, Grandjean P. Asthma and allergy in children with and without prior measles, mumps, and rubella vaccination. Pediatr Allergy Immunol 2015;26:742–9
Linehan MF, Nurmatov U, Frank TL, Niven RM, Baxter DN, Sheikh A. Does BCG vaccination protect against childhood asthma? Final results from the Manchester Community Asthma Study retrospective cohort study and updated systematic review and meta-analysis. J Allergy Clin Immunol 2014;133:688–95.e14
Olesen AB, Juul S, Thestrup-Pedersen K. Atopic dermatitis is increased following vaccination for measles, mumps and rubella or measles infection. Acta Derm Venereol 2003;83:445–50
Thomson JA, Widjaja C, Darmaputra AA, et al. Early childhood infections and immunisation and the development of allergic disease in particular asthma in a high-risk cohort: A prospective study of allergy-prone children from birth to six years. Pediatr Allergy Immunol 2010;21:1076–85
Bremner SA, Carey IM, DeWilde S, et al. Timing of routine immunisations and subsequent hay fever risk. Arch Dis Child 2005;90:567–73
McDonald KL, Huq SI, Lix LM, Becker AB, Kozyrskyj AL. Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma. J Allergy Clin Immunol 2008;121:626–31
Chung EK, Casey R, Pinto-Martin JA, Pawlowski NA, Bell LM. Routine and influenza vaccination rates in children with asthma. Ann Allergy Asthma Immunol 1998;80:318–22
Kuehni CE, Davis A, Brooke AM, Silverman M. Are all wheezing disorders in very young (preschool) children increasing in prevalence?. Lancet 2001;357:1821–5
Spycher BD, Silverman M, Kuehni CE. Timing of routine vaccinations and the risk of childhood asthma. J Allergy Clin Immunol 2008;122:656; author reply 657—58
Johansson SG, Bieber T, Dahl R, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004;113:832–6
National Center for Immunization and Respiratory Diseases. General recommendations on immunization — recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2011;60:1–64
Bergfors E, Trollfors B. Sixty-four children with persistent itching nodules and contact allergy to aluminium after vaccination with aluminiumadsorbed vaccines-prognosis and outcome after booster vaccination. Eur J Pediatr 2013;172:171–7
Kang LW, Crawford N, Tang ML, et al. Hypersensitivity reactions to human papillomavirus vaccine in Australian schoolgirls: retrospective cohort study. BMJ 2008;337:a2642
Centers for Disease Control and Prevention (CDC). Syncope after vaccination — United States, January 2005–July 2007. MMWR Morb Mortal Wkly Rep 2008;57:457–60
Fritsche PJ, Helbling A, Ballmer-Weber B. Vaccine hypersensitivity — update and overview. Swiss Med Wkly 2010;140:238–46
Baxter DN. Measles immunization in children with a history of egg allergy. Vaccine 1996;14:131–4
Fox A, Lack G. Egg allergy and MMR vaccination. Br J Gen Pract 2003;53:801–2
https://www.rki.de/SharedDocs/FAQ/Impfen/AllgFr_Grunderkrankungen/FAQ03.html;jsessionid=B955971009F0639A146A59ADAEC885 FC.2_cid390?nn=2391120; [Zugriff am 5.12. 2017]
McKinney KK, Webb L, Petersen M, et al. Ovalbumin content of 2010—2011 influenza vaccines. J Allergy Clin Immunol 2011;127:1629–32
Des Roches A, Paradis L, Gagnon R, et al. Eggallergic patients can be safely vaccinated against influenza. J Allergy Clin Immunol 2012;130:1213–36
Fung I, Spergel JM. Administration of influenza vaccine to pediatric patients with egg-induced anaphylaxis. J Allergy Clin Immunol 2012;129:1157–9
Webb L, Petersen M, Boden S, et al. Singledose influenza vaccination of patients with egg allergy in a multicenter study. J Allergy Clin Immunol 2011;128:218–9
Committee on Infectious Diseases, American Academy of Pediatrics. Recommendations for prevention and control of influenza in children, 2012–2013. Pediatrics 2012;130:780–92
Grohskopf LA, Sokolow LZ, Broder KR, et al. Prevention and control of seasonal influenza with vaccines. MMWR Recomm Rep 2016;65:1–56
Kelso JM, Greenhawt MJ, Li JT. Adverse reactions to vaccines practice parameter 2012 update. J Allergy Clin Immunol 2012;130:25–43
American Academy of Pediatrics. Active Immunization. In: Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2009 Report of the Committee on Infectious Diseases. Elk Grove Village: American Academy of Pediatrics 2009:48–9
Grüber C, Ankermann T, Bauer CP, et al. Impfung von Kindern mit erhöhtem Allergierisiko. Monatsschr Kinderheilkd 2016;164:52–8
Grüber C, Niggemann B. A practical approach to immunization in atopic children. Allergy 2002; 57: 472–9
Nilsson L, Brockow K, Alm J, et al. Vaccination and allergy: EAACI position paper, practical aspects. Pediatr Allergy Immunol 2017;28:628–40
Wood RA, Berger M, Dreskin SC, et al; Hypersensitivity Working Group of the Clinical Immunization Safety Assessment (CISA) Network. An algorithm for treatment of patients with hypersensitivity reactions after vaccines. Pediatrics 2008;122:e771–7
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Schmidt, S.M., Spindler, T. & Ankermann, T. Allergien und Impfungen. Allergo J 28, 46–52 (2019). https://doi.org/10.1007/s15007-019-1989-4
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DOI: https://doi.org/10.1007/s15007-019-1989-4