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Th22-Zellen bei allergischen Erkrankungen

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Zusammenfassung

Das Feld der T-Zell-Immunologie ist unübersichtlich geworden. Immer neue Populationen von Helferzellen, in letzter Zeit auch zunehmend Lymphozyten der angeborenen Immunität, werden beschrieben. Wir beginnen erst zu verstehen, welche spezifischen Funktionen von welchen Subtypen wahrgenommen werden. Th22-Zellen sind terminal differenzierte und sehr spezialisierte T-Helferzellen, die sich durch die Sekretion ihres Leitzytokins IL-22 bei fehlender Sekretion von IL-4, IL-17 und IFN-γ auszeichnen.

Ihre Hauptfunktion ist die Protektion, aber auch die Modulation von entzündetem oder geschädigtem Gewebe, insbesondere der Haut und der Lunge. Dieser Übersichtsartikel fasst unsere bisherigen Erkenntnisse zum Phänotyp der Th22-Zellen sowie deren Rolle bei allergischen Erkrankungen zusammen.

Zitierweise: Eyerich K, Eyerich S. Th 22 cells in allergic disease. Allergo J Int 2015;24:1–7 DOI: 10.1007/s40629-015-0039-3

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Abbreviations

ACD:

Allergische Kontaktdermatitis

AE:

Atopisches Ekzem

AHR:

Aryl-Hydrocarbon-Rezeptor

CMC:

Mukokutane Candidose

FGF:

Fibroblastenwachstumsfaktoren

IFN:

Interferon

IL:

Interleukin

ILC:

Innate lymphoid cells, Lymphozyten der angeborenen Immunität

Lti:

Lymphoid-tissue inducer

MMP:

Matrixmetallproteinasen

PDGF:

Platelet-derived growth factor

ROR:

RAR-related orphan receptors

TCR:

T-Zell-Rezeptor

TGF:

Transforming growth factor

Th:

T-Helferzellen

TLR:

Toll-like-Rezeptor

TNF:

Tumornekrosefaktor

Treg :

Regulatorische T-Zelle

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Authors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München Biedersteiner, Straße 29, 80802, München, Deutschland

    Kilian Eyerich

  2. ZAUM — Zentrum Allergie & Umwelt, Technische Universität und Helmholtz Zentrum, München, Deutschland

    Stefanie Eyerich

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  1. Kilian Eyerich
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Correspondence to Kilian Eyerich.

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Englische Fassung http://link.springer.com/journal/40629

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Eyerich, K., Eyerich, S. Th22-Zellen bei allergischen Erkrankungen. Allergo J 24, 17–23 (2015). https://doi.org/10.1007/s15007-015-0750-x

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