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Grenzformen zwischen Typ-1- und Typ-2-Diabetes

Seminar / Diabetes

Latent autoimmune diabetes in adults

  • FORTBILDUNG -- SEMINAR
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MMW - Fortschritte der Medizin Aims and scope

Aktuell ist in Diskussion, ob die dichotome Einteilung in Typ-1- und Typ-2-Diabetes der Wirklichkeit gerecht wird. So sehen wir im Alltag zunehmend Überschneidungen zwischen diesen beiden Kategorien, und es entstehen Begriffe wie Doppel- und LADA-Diabetes.

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Literatur

  1. Hawa MI & Action LADA 7 Consortium. Adult-Onset Autoimmune Diabetes in Europe is Prevalent with a broad Clinical Phenotype. Diabetes Care 2013; 36: 908–913

    Article  Google Scholar 

  2. Turner R et al. Prospective Diabetes Study Group, UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes, Lancet 1997; 350: 1288–1293

    Article  CAS  Google Scholar 

  3. Tuomi T et al. The many faces of diabetes: A disease with increasing heterogeneity. Lancet 2014; 383: 1084–94

    Article  Google Scholar 

  4. Fourlanos S, Dotta F, Greenbaum CJ, et al. Latent autoimmune diabetes in adults (LADA) should be less latent. Diabetologia 2005; 48: 2206–12

    Article  CAS  Google Scholar 

  5. Zampetti S, Campagna G, Tiberti C, et al. High GADA titer increases the risk of insulin requirement in LADA patients: a 7-year follow-up (NIRAD study 7). Eur J Endocrinol 2014; 71: 697–704

    Article  Google Scholar 

  6. Hernandez M, Mollo A, Marsal JR, et al. Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9. BMC Endocr Disord 2015; 15: 1

    Article  Google Scholar 

  7. Pieralice S, Pozilli P. Latent Autoimmune Diabetes in Adults: A Review on Clinical Implications and Management. Diabetes Metab J 2018; 42: 451–464

    Article  Google Scholar 

  8. Maruyama T, et al. Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitus. J Clin Endocrinol Metab 2008; 93: 2115–21

    Article  CAS  Google Scholar 

  9. Yang Z, et al. Rosiglitazone preserves islet beta-cell function of adult-onset latent autoimmune diabetes in 3 years follow-up study. Diabetes Research and Clinical Practice 2009; 83: 54–60

    Article  CAS  Google Scholar 

  10. Zhao Y, Yang L, Xiang Y, et al. Dipeptidyl peptidase 4 inhibitor sitagliptin maintains ß-cell function in patients with recent-onset latent autoimmune diabetes in adults: one year prospective study. J Clin Endocrinol Metab 2014; 99: E876–80

    Article  CAS  Google Scholar 

  11. Johansen OE, Boehm B, Grill V, et al. C-Peptide Levels in Latent Autoimmune Diabetes in Adults Treated With Linagliptin Versus Glimepiride: Exploratory results from a 2-year, double-blind, randomised, controlled study. Diabetes Care 2014; 37: e11–e12

    Article  CAS  Google Scholar 

  12. Pettus J, Hirsch I, Edelman S. GLP-1 agonists in type 1 diabetes. Clin Immunol 2013; 149: 317–23

    Article  CAS  Google Scholar 

  13. Pozzilli P, Leslie RD, Peters AL, et al. Dulaglutide treatment results in effective glycaemic control in latent autoimmune diabetes in adults (LADA): a post-hoc analysis of the AWARD-2, -4 and -5 trials. Diabetes Obes Metab 2018; 20: 1490–8

    Article  CAS  Google Scholar 

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Correspondence to Michael Hummel.

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Hummel, M. Grenzformen zwischen Typ-1- und Typ-2-Diabetes. MMW - Fortschritte der Medizin 162, 60–63 (2020). https://doi.org/10.1007/s15006-020-0577-6

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  • DOI: https://doi.org/10.1007/s15006-020-0577-6

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