Skip to main content
SpringerLink
Log in

Zufallsbefund Leukopenie — unverzüglich zum Hämatologen?

Onkologische Zufallsbefunde

Incidental finding of leukopenia — directly to the hematologist?

  • FORTBILDUNG -- SCHWERPUNKT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

Ist die Zahl der Leukozyten im Blut zu niedrig, kann das ganz verschiedene Ursachen haben, von einem Infekt bis hin zu seltenen Erkrankungen des Blutes oder des Knochenmarks. Wann können Sie abwarten, wann müssen Sie rasch handeln?

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Palmblad J, Dufour C, Papadaki HA. How we diagnose neutropenia in the adult and elderly patient. Haematologica 2014; 99: 1130–1133

    Article  Google Scholar 

  2. Kuderer NM, Dale DC, Crawford J, Cosler LE, Lyman GH. Mortality, morbidity, and cost associated with febrile neutropenia in adult cancer patients. Cancer 2006; 106: 2258–2266

    Article  Google Scholar 

  3. Palmblad J, Siersma V, Lind B, Bjerrum OW, Hasselbalch H, Andersen CL. Age-related prevalence and clinical significance of neutropenia - isolated or combined with other cytopenias. Am J Hematol 2020; Im Internet: https://doi.org/10.1002/ajh.25756

    Google Scholar 

  4. Andersen CL, Tesfa D, Siersma VD, Sandholdt H, Hasselbalch H, Bjerrum OW, Felding P, Lind B, Olivarius N de F, Palmblad J. Prevalence and clinical significance of neutropenia discovered in routine complete blood cell counts: a longitudinal study. J Intern Med 2016; 279: 566–575

    Article  CAS  Google Scholar 

  5. Christen D, Brümmendorf T, Panse J. Leukopenie — ein diagnostischer Leitfaden für die Praxis. DMW - Deutsche Medizinische Wochenschrift 2017; 142: 1744–1749 Im Internet: https://doi.org/10.1055/s-0043-113123

    Article  Google Scholar 

  6. Rodak Bernadette JHC. Clinical Hematology Atlas, Fifth Edition. Elsevier, 2017

    Google Scholar 

  7. Gibson C, Berliner N. How we evaluate and treat neutropenia in adults. Blood 2014; 124: 1251–1258

    Article  CAS  Google Scholar 

  8. Foucar K, Duncan MH, Smith KJ. Practical approach to the investigation of neutropenia. Clin Lab Med 1993; 13: 879–894

    Article  CAS  Google Scholar 

  9. Averbuch D, Orasch C, Cordonnier C, Livermore DM, Mikulska M, Viscoli C, Gyssens IC, Kern WV, Klyasova G, Marchetti O, Engelhard D, Akova M, ECIL4, a joint venture of EBMT, EORTC, ICHS, ESGICH/ESCMID and ELN. European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia. Haematologica 2013; 98: 1826–1835

    Article  Google Scholar 

  10. Bhatt V, Saleem A. Review: Drug-induced neutropenia—pathophysiology, clinical features, and management. Ann Clin Lab Sci 2004; 34: 131–137

    PubMed  Google Scholar 

  11. Andrès E, Zimmer J, Mecili M, Weitten T, Alt M, Maloisel F. Clinical presentation and management of drug-induced agranulocytosis. Expert Rev Hematol 2011; 4: 143–151

    Article  Google Scholar 

  12. Garbe E. Non-chemotherapy drug-induced agranulocytosis. Expert Opin Drug Saf 2007; 6: 323–335

    Article  CAS  Google Scholar 

  13. Röhrig G, Becker I, Pappas K, Polidori MC, Schulz RJ. Analysis of cytopenia in geriatric inpatients. Z Gerontol Geriatr 2018; 51: 231–236

    Article  Google Scholar 

  14. Tesfa D, Gelius T, Sander B, Kimby E, Fadeel B, Palmblad J, Hägglund H. Late-onset neutropenia associated with rituximab therapy: evidence for a maturation arrest at the (pro)myelocyte stage of granulopoiesis. Med Oncol 2008; 25: 374–379

    Article  CAS  Google Scholar 

  15. Jabbour N, DiGiuseppe JA, Usmani S, Tannenbaum S. Copper deficiency as a cause of reversible anemia and neutropenia. Conn Med 2010; 74: 261–263

    PubMed  Google Scholar 

  16. Hartmann L, Metzeler KH. Clonal hematopoiesis and preleukemia-Genetics, biology, and clinical implications. Genes Chromosomes Cancer 2019; Im Internet: https://doi.org/10.1002/gcc.22756

    Google Scholar 

  17. Malcovati L, Gallì A, Travaglino E, Ambaglio I, Rizzo E, Molteni E, Elena C, Ferretti VV, Catricalà S, Bono E, Todisco G, Bianchessi A, Rumi E, Zibellini S, Pietra D, Boveri E, Camaschella C, Toniolo D, Papaemmanuil E, Ogawa S, Cazzola M. Clinical significance of somatic mutation in unexplained blood cytopenia. Blood 2017; 129: 3371–3378

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Labor für Leukämiediagnostik, Medizinische Klinik und Poliklinik III, Klinikum der Universität München, Marchioninistr. 15, D81377, München, Deutschland

    Frank Ziemann &  Klaus Metzeler

Authors
  1. Frank Ziemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Klaus Metzeler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Frank Ziemann.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ziemann, F., Metzeler, K. Zufallsbefund Leukopenie — unverzüglich zum Hämatologen?. MMW - Fortschritte der Medizin 162, 38–41 (2020). https://doi.org/10.1007/s15006-020-0389-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-020-0389-8

Keywords

Search

Navigation