Skip to main content
SpringerLink
Log in

Einteilung anhand der klinischen Befunde und Labordaten

Mögliche, wahrscheinliche oder sichere Neuroborreliose?

Lyme neuroborreliosis

  • FORTBILDUNG . SCHWERPUNKT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

Treten 3—4 Wochen nach Zeckenstich z. B. radikuläre Schmerzen oder periphere Paresen auf, sollten Sie an eine Lyme-Neuroborreliose denken. Aber auch nach Monaten bis Jahren ist eine Manifestation noch möglich. Wie klären Sie die Erkrankung ab?

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2

Literatur

  1. Enkelmann J, Bohmer M, Fingerle V et al. Incidence of notified Lyme borreliosis in Germany, 2013-2017. Sci Rep 2018;8:14976.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Koedel U, Fingerle V, Pfister HW. Lyme neuroborreliosis-epidemiology, diagnosis and management. Nat Rev Neurol 2015;11:44656.

    Article  Google Scholar 

  3. Rauer S, Kastenbauer S, Fingerle V et al. Lyme Neuroborreliosis. Dtsch Arztebl Int 2018;115:751–6.

    PubMed  PubMed Central  Google Scholar 

  4. Rupprecht TA, Koedel U, Fingerle V et al. The pathogenesis of lyme neuroborreliosis: from infection to inflammation. Mol Med 2008;14:205–12.

    Article  CAS  PubMed  Google Scholar 

  5. Hansen K, Lebech AM. The clinical and epidemiological profile of Lyme neuroborreliosis in Denmark 1985–1990. A prospective study of 187 patients with Borrelia burgdorferi specific intrathecal antibody production Brain. 1992;115:399–423.

    PubMed  Google Scholar 

  6. Reik L, Steere AC, Bartenhagen NH et al. Neurologic abnormalities of Lyme disease. Medicine (Baltimore) 1979;58:281–94.

    Article  CAS  Google Scholar 

  7. Rupprecht TA, Birnbaum T, Pfister HW. [Pain and neuroborreliosis: significance, diagnosis and treatment]. Schmerz 2008;22:615–23.

    Article  CAS  PubMed  Google Scholar 

  8. Rauer S, Kastenbauer S, Hofmann H, Fingerle V, Huppertz HI, Hunfeld KP, Krause A, Ruf B. Neuroborreliose. S3-Leitlinie. Deutsche Gesellschaft für Neurologie (Hrsg.), Leitlinien für Diagnostik und Therapie in der Neurologie, Online: www.dgn.org/leitlinien. 2018.

    Google Scholar 

  9. Kruger H, Kohlhepp W, Konig S. Follow-up of antibiotically treated and untreated neuroborreliosis. Acta Neurol Scand 1990;82:59–67.

    Article  CAS  PubMed  Google Scholar 

  10. Back T, Grunig S, Winter Y et al. Neuroborreliosis-associated cerebral vasculitis: longterm outcome and health-related quality of life. J Neurol 2013;260:1569–75.

    Article  PubMed  Google Scholar 

  11. Wittwer B, Pelletier S, Ducrocq X et al. Cerebrovascular Events in Lyme Neuroborreliosis. J Stroke Cerebrovasc Dis 2015;24:1671–8.

    Article  PubMed  Google Scholar 

  12. Fingerle V, Eiffert H, Gessner A, Göbel UB, Hofmann H, Hunfeld KP, Krause A, Pfister HW, Reischl U, Sing A, Stanek G, Wilske B, Zöller L. MIQ12: Lyme-Borreliose. Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik. 2.Auflage ed. Urban & Fischer Verlag/Elsevier GmbH; 2017.

    Google Scholar 

  13. Lager M, Dessau RB, Wilhelmsson P et al. Serological diagnostics of Lyme borreliosis: comparison of assays in twelve clinical laboratories in Northern Europe. Eur J Clin Microbiol Infect Dis 2019;38:1933–45.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Cerar T, Ogrinc K, Cimperman J et al. Validation of cultivation and PCR methods for diagnosis of Lyme neuroborreliosis. J Clin Microbiol 2008;46:3375–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Moore A, Nelson C, Molins C et al. Current Guidelines, Common Clinical Pitfalls, and Future Directions for Laboratory Diagnosis of Lyme Disease, United States. Emerg Infect Dis 2016;22(7).

    Google Scholar 

  16. Ogrinc K, Lusa L, Lotric-Furlan S et al. Course and Outcome of Early European Lyme Neuroborreliosis (Bannwarth Syndrome): Clinical and Laboratory Findings. Clin Infect Dis 2016;63:245–53.

    Article  Google Scholar 

  17. Ljostad U, Skogvoll E, Eikeland R et al. Oral doxycycline versus intravenous ceftriaxone for European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blind, randomised trial. Lancet Neurol 2008;7:690–5.

    Article  PubMed  Google Scholar 

  18. Solheim AM, Ljostad U, Mygland A. Six versus two weeks treatment with doxycycline in Lyme neuroborreliosis: the protocol of a multicentre, non-inferiority, double-blinded and randomised controlled trial. BMJ Open 2019;9:e027083.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Ljostad U, Mygland A. Remaining complaints 1 year after treatment for acute Lyme neuroborreliosis; frequency, pattern and risk factors. Eur J Neurol 2010;17:118–23.

    Article  CAS  PubMed  Google Scholar 

  20. Koedel U, Pfister HW. Lyme neuroborreliosis. Curr Opin Infect Dis 2017;30:101–7.

    PubMed  Google Scholar 

  21. Dersch R, Sommer H, Rauer S et al. Prevalence and spectrum of residual symptoms in Lyme neuroborreliosis after pharmacological treatment: a systematic review. J Neurol 2016;263:17–24.

    Article  CAS  PubMed  Google Scholar 

  22. Wormser GP, Weitzner E, McKenna D et al. Long-term assessment of health-related quality of life in patients with culture-confirmed early Lyme disease. Clin Infect Dis 2015;61:244–7.

    Article  PubMed  Google Scholar 

  23. Wills AB, Spaulding AB, Adjemian J et al. Long-term follow-up of patients with Lyme disease: longitudinal analysis of clinical and quality-of-life easures. Clin Infect Dis 2016;62:1546–51.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Berende A, Ter Hofstede HJ, Vos FJ et al. Randomized trial of longer-term therapy for symptoms attributed to Lyme disease. N Engl J Med 2016;374:1209–20.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurologische Klinik und Poliklinik, Klinikum Großhadern, Ludwig-Maximilians-Univ., Marchioninistr. 15, D-81377, München, Deutschland

    Uwe Ködel &  Hans-Walter Pfister

  2. Nationales Referenzzentrum für Borrelien, Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Oberschleißheim, Deutschland

    Volker Fingerle

Authors
  1. Uwe Ködel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Volker Fingerle
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hans-Walter Pfister
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hans-Walter Pfister.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ködel, U., Fingerle, V. & Pfister, HW. Mögliche, wahrscheinliche oder sichere Neuroborreliose?. MMW - Fortschritte der Medizin 162, 44–48 (2020). https://doi.org/10.1007/s15006-020-0160-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-020-0160-1

Keywords

Search

Navigation