Zusammenfassung
Die nicht-alkoholische Fettleber-Erkrankung (NAFLD) ist die am stärksten zunehmende Lebererkrankung weltweit. Und nicht nur die Leber ist gefährdet: Die NAFLD ist ein unabhängiger Risikofaktor für die Entstehung von Herz-Kreislauf- und extrahepatischen Tumorerkrankungen. Zudem drohen eine Insulinresistenz und eine Störung des Fettstoffwechsels.
Literatur
Younossi Z, Anstee QM, Marietti M et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nature reviews Gastroenterology & hepatology 2018;15:11–20
Younossi ZM, Blissett D, Blissett R et al. The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe. Hepatology. 2016;64:1577–86
Mikolasevic I, Filipec-Kanizaj T, Mijic M et al. Nonalcoholic fatty liver disease and liver transplantation - Where do we stand? World J Gastroenterol. 2018;24:1491–1506
Younossi ZM. The epidemiology of nonalcoholic steatohepatitis. Clinical liver disease. 2018;11:92–4
Younossi Z, Tacke F, Arrese M et al. Global Perspectives on Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis. Hepatology. 2019;69:2672–82
Bedogni G, Miglioli L, Masutti F et al. Incidence and natural course of fatty liver in the general population: the Dionysos study. Hepatology. 2007;46:1387–91
Mann JP, Anstee QM. NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD. Nature reviews Gastroenterology & hepatology. 2017;14:506–7
Younossi ZM, Koenig AB, Abdelatif D et al. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73–84
Allen AM, Therneau TM, Larson JJ et al. Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death: A 20 year-community study. Hepatology. 2018;67:1726–36
Tesfay M, Goldkamp WJ, Neuschwander-Tetri BA. NASH: The Emerging Most Common Form of Chronic Liver Disease. Missouri medicine. 2018;115:225–9
Dulai PS, Singh S, Patel J et al. Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis. Hepatology. 2017;65:1557–65
Younossi ZM. Non-alcoholic fatty liver disease - A global public health perspective. Journal of hepatology. 2019;70:531–44
Labenz C, Prochaska JH, Huber Y et al. Cardiovascular Risk Categories in Patients With Nonalcoholic Fatty Liver Disease and the Role of Low-Density Lipoprotein Cholesterol. Hepatol Commun. 2019;3:1472–81
Labenz C, Huber Y, Michel M et al. Impact of NAFLD on the Incidence of Cardiovascular Diseases in a Primary Care Population in Germany. Digestive diseases and sciences. 2019; in press
Huber Y, Boyle M, Hallsworth K et al. Healthrelated Quality of Life in Nonalcoholic Fatty Liver Disease Associates With Hepatic Inflammation. Clin gastroenterol hepatol. 2019;17:2085–92
Singh S, Allen AM, Wang Z et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin gastroenterol hepatol. 2015;13:643–54; e641—49; quiz e639—40
Mantovani A, Dauriz M, Byrne CD et al. Association between nonalcoholic fatty liver disease and colorectal Tumours in asymptomatic adults undergoing screening colonoscopy: a systematic review and metaanalysis. Metabolism: clinical and experimental 2018; https://doi.org/10.1016/j.metabol.2018.06.004
European Association for the Study of the L, European Association for the Study of D, European Association for the Study of O. EASLEASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J hepatol. 2016;64:1388–1402
Roeb E, Steffen HM, Bantel H et al. S2k Guideline non-alcoholic fatty liver disease. Z Gastroenterol. 2015;53:668–723
Vilar-Gomez E, Martinez-Perez Y, CalzadillaBertot L et al. Weight Loss Through Lifestyle Modification Significantly Reduces Features of Nonalcoholic Steatohepatitis. Gastroenterology. 2015;149:367–78;e365;quiz e314—65
Armstrong MJ, Gaunt P, Aithal GP et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet. 2016;387:679–90
Sanyal AJ, Chalasani N, Kowdley KV et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. New Engl J Med. 2010;362:1675–85
Bril F, Biernacki DM, Kalavalapalli S et al. Role of Vitamin E for Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes: A Randomized Controlled Trial. Diabetes care. 2019;42:1481–8
Younossi Z, Ratziu V, Loomba R et al. GS06-Positive Results from REGENERATE: A Phase 3 International, Randomized, Placebo-Controlled Study Evaluating Obeticholic Acid Treatment for NASH. J hepatol. 2019;70:e5
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Schattenberg, J.M. Die nicht-alkoholische Fettleber-Erkrankung. MMW - Fortschritte der Medizin 162, 56–62 (2020). https://doi.org/10.1007/s15006-020-0004-z
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DOI: https://doi.org/10.1007/s15006-020-0004-z