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Katatonie in der klinischen Realität: unterdiagnostiziert und vergessen

Catatonia in clinical reality: underdiagnosed and forgotten

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MMW - Fortschritte der Medizin Aims and scope

Zusammenfassung

Hintergrund

Die Katatonie ist ein noch wenig verstandenes, durchaus häufiges, aber doch oft übersehendes Krankheitsbild. Folgen für die Patienten sind eine unzureichende Behandlung, verlängerte Krankenhausaufenthalte und schwerwiegendere Komplikationen.

Methode

In dieser übersichtsarbeit werden die Ursachen für eine Unterdiagnose dargestellt und Maßnahmen zu deren Vermeidung genannt, Hilfen zur differenzialdiagnostischen Einordnung der Katatonie gegeben und die Therapie kurz erläutert.

Ergebnisse und Schlussfolgerungen

Katatonien werden in erster Linie mit Schizophrenie in Verbindung gebracht. Sie werden aber auch bei anderen Erkrankungen wie z. B. dem malignen neuroleptischen Syndrom (MNS), bei Enzephalitiden und auch bei Allgemeinerkrankungen beobachtet. Durch einfache Maßnahmen wie eine gründliche körperliche Untersuchung, das Beachten verbaler und non-verbaler Zeichen der Katatonie sowie durch psychiatrische Konsultationen in Allgemeinkrankenhäusern lässt sich vermeiden, dass eine Katatonie übersehen wird. Zur Behandlung der akuten Katatonie sind in erster Linie die hochdosierte Gabe von Benzodiazepinen sowie eine Elektrokonvulsionstherapie empfohlen.

Abstract

Background

Catatonia is still a poorly understood, quite common, but often overlooked clinical picture. Consequences for patients are inadequate treatment, prolonged hospital stays and more serious complications.

Method

In this overview, the causes for an underdiagnosis are presented and measures for their prevention named, help for the differential diagnostic classification of catatonia is offered and the treatment is briefly explained.

Results and conclusions

Catatonia is primarily associated with schizophrenia, but is also observed in other diseases such as neuroleptic malignant syndrome (MNS), in encephalitis and also in systemic diseases. Underdiagnosis can be avoided by simple measures such as a thorough physical examination, observance of verbal and non-verbal signs of catatonia, and psychiatric consultations in general hospitals. For the treatment of acute catatonia, the high-dose administration of benzodiazepines and electroconvulsive therapy are recommended.

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Literatur

  1. Kahlbaum KL. Die Katatonie: oder das Spannungsirresein, eine klinische Form psychischer Krankheit. Hirschwald Verlag, Berlin 1874, S. 5.

    Google Scholar 

  2. Stuivenga M et al. Prevalence of the catatonic syndrome in an acute inpatient sample. Front Psychiatry 2014; 5: 174.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ungvari GS et al. The catatonia conundrum: evidence of psychomotor phenomena as a symptom dimension in psychotic disorders. Schizophr Bull 2010; 36(2): 231–238.

    Article  PubMed  Google Scholar 

  4. Schultze-Lutter F, Schimmelmann BG. Psychotische Störungen im DSM-5. DSM-5 Kommentar. Z Kinder Jugendpsychiatr Psychother 2014; 42(3): 193–202.

    Article  PubMed  Google Scholar 

  5. Llesuy JR et al. Catatonia under-diagnosis in the general hospital. J Neuropsychiatry Clin Neurosci 2018; 30(2): 145–151.

    Article  PubMed  Google Scholar 

  6. Madigand J et al. Catatonic syndrome: From detection to therapy. Encephale 2016; 42(4): 340–345.

    Article  CAS  PubMed  Google Scholar 

  7. Fink M. Catatonia: a syndrome appears, disappears, and is rediscovered. Can J Psychiatry 2009; 54(7): 437–445.

    Article  PubMed  Google Scholar 

  8. Daniels J. Catatonia: clinical aspects and neurobiological correlates. J Neuropsychiatry Clin Neurosci 2009; 21(4): 371–380.

    Article  CAS  PubMed  Google Scholar 

  9. Garcia-Agudo LF et al. Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion. FASEB J 2019; 33(7): 8634–8647.

    Article  CAS  PubMed  Google Scholar 

  10. Janova H et al. Microglia ablation alleviates myelin-associated catatonic signs in mice. J Clin Invest 2018; 128(2): 734–745.

    Article  PubMed  Google Scholar 

  11. Poggi G et al. Cortical network dysfunction caused by a subtle defect of myelination. Glia 2016; 64(11): 2025–2040.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Pease-Raissi SE et al. Micro(glial)-managing executive function: white matter inflammation drives catatonia. J Clin Invest 2018; 128(2): 564–565.

    Article  PubMed  Google Scholar 

  13. Rogers JP et al. Catatonia and the immune system: a review. Lancet Psychiatry 2019; 6(7): 620–630.

    Article  PubMed  Google Scholar 

  14. Bakker PR et al. Novel directions for psychiatric diagnosis: from psychopathology to motor function to monitoring technology. Epidemiol Psychiatr Sci 2013; 22(4): 289–295.

    Article  CAS  PubMed  Google Scholar 

  15. Margetić B et al. Neuroleptic malignant syndrome and its controversies. Pharmacoepidemiol Drug Saf 2011; 20(6): 659.

    Article  Google Scholar 

  16. Saddawi-Konefka D et al. Catatonia in the ICU: an important and underdiagnosed cause of altered mental status. A case series and review of the literature. Crit Care Med 2014; 42(3): e234–e241.

    Article  PubMed  Google Scholar 

  17. Tandon R et al. Definition and description of schizophrenia in the DSM-5. Schizophr Res 2013; 150(1): 3–10.

    Article  PubMed  Google Scholar 

  18. Tandon R. Schizophrenia and other psychotic disorders in Diagnostic and Statistical Manual of Mental Disorders (DSM)-5: clinical implications of revisions from DSM-IV. Indian J Psychol Med 2014; 36(3): 223–225.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Carpenter WT et al. Psychotic disorders in DSM-5: summary of changes. Asian J Psychiatr 2013; 6(3): 266–268.

    Article  PubMed  Google Scholar 

  20. Tandon R et al. Catatonia in DSM-5. Schizophr Res 2013; 150(1): 26–30.

    Article  PubMed  Google Scholar 

  21. Parker GF. DSM-5 and psychotic and mood disorders. J Am Acad Psychiatry Law 2014; 42(2): 182–190.

    PubMed  Google Scholar 

  22. American Psychitaric Association. Diagnostic and statistical manual of mental disorders (DSM-5). American Psychiatric Pub 2013 May 22.

    Book  Google Scholar 

  23. Wilson JE et al. The diagnostic criteria and structure of catatonia. Schizophr Res 2015; 164(1—3): 256–262.

    Article  PubMed  Google Scholar 

  24. Paulzen M et al. Schizophrenia and other psychotic disorders in DSM-5: summary of the changes compared to DSM-IV. Nervenarzt 2014; 85(5): 533–542.

    Article  CAS  PubMed  Google Scholar 

  25. Peralta V et al. Motor features in psychotic disorders. II. Development of diagnostic criteria for catatonia. Schizophr Res 2001; 47(2—3): 117–126.

    Article  CAS  PubMed  Google Scholar 

  26. Mazzone L et al. Catatonia in patients with autism: prevalence and management. CNS Drugs 2014; 28(3): 205–215.

    Article  CAS  PubMed  Google Scholar 

  27. Barry H et al. Anti-N-methyl-d-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment. BJPsych Bull 2015; 39(1): 19–23.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Mann A et al. A multidisciplinary approach to the treatment of anti-NMDA-receptor antibody encephalitis: a case and review of the literature. J Neuropsychiatry Clin Neurosci 2012; 24(2): 247–254.

    Article  CAS  PubMed  Google Scholar 

  29. AWMF S3-Leitlinie Schizophrenie, Herausgebende Fachgesellschaft: DGPPN, verfügbar online: https://www.awmf.org/leitlinien/detail/ll/038-009.html (zuletzt aufgerufen am 8.10.2019).

  30. Pelzer ACM et al. Systematic review of catatonia treatment. Neuropsychiatr Dis Treat 2018; 14: 317–326.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Palm U et al. Electroconvulsive therapy and corpus callosum aplasia: a case report. J ECT 2011; 27(1): e17–e20.

    Article  PubMed  Google Scholar 

  32. Palm U et al. Electroconvulsive therapy and corpus callosum aplasia: a 3-year followup. Case Rep Psychiatry 2011; 2011: 638506.

    PubMed  PubMed Central  Google Scholar 

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Correspondence to Kristina Adorjan.

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This article is part of a supplement not sponsored by the industry.

Interessenkonflikt

Dr. Kristina Adorjan, Prof. Dr. Peter Falkai und Prof. Dr. Oliver Pogarell erklären, dass keine finanziellen Interessenkonflikte im Zusammenhang mit dieser Arbeit vorliegen.

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Adorjan, K., Falkai, P. & Pogarell, O. Katatonie in der klinischen Realität: unterdiagnostiziert und vergessen. MMW - Fortschritte der Medizin 161 (Suppl 7), 7–11 (2019). https://doi.org/10.1007/s15006-019-1173-5

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  • DOI: https://doi.org/10.1007/s15006-019-1173-5

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