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Verbesserte LDL-Cholesterin-Zielwerterreichung bei Patienten mit akutem Koronarsyndrom in der kardiologischen Rehabilitation: PATIENT-CARE-Register

Improvement of LDL-C target value achievement through cardiac rehabilitation in patients with acute coronary syndrome: PATIENT-CARE registry

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MMW - Fortschritte der Medizin Aims and scope

Zusammenfassung

Hintergrund

Für Patienten nach akutem Koronarsyndrom beinhaltet die Teilnahme an einer kardiologischen Rehabilitation neben der Lebensstiländerung auch die optimale Einstellung auf sekundärpräventive Medikamente. Dadurch können sehr effektiv Folgeereignisse verhindert werden.

Methode

Die PATIENT-CARE-Registerstudie untersuchte die Behandlung der Patienten während der Rehabilitation. Besonders interessierte dabei, ob die Zielwerte für LDL-Cholesterin (LDL-C) erreicht wurden.

Ergebnisse

Die Rate der behandelten Patienten nahm in nahezu allen Medikationsklassen zu. Bei der Entlassung erhielten 96,7% der Patienten Statine, 98,5% Antithrombotika und 22,3% Antidiabetika. Das LDL-C wurde während der Rehabilitation deutlich gesenkt — im Mittel um 21,3 mg/dl (0,55 mmol/l). Den LDL-C-Zielwert erreichten 41,9% der Patienten.

Schlussfolgerung

Die Ergebnisse zeigen, dass die Optimierung der medikamentösen Sekundärprävention im ambulanten Bereich unbedingt und konsequent fortgesetzt werden muss.

Abstract

Background

For patients undergoing acute coronary syndrome, participation in cardiac rehabilitation includes, in addition to lifestyle modification, optimal adjustment to secondary preventive medication. As a result, follow-up events can be prevented very effectively.

Method

The PATIENT-CARE registry study examined the treatment of patients during rehabilitation. Of particular interest was whether LDL cholesterol (LDL-C) targets were met.

Results

The rate of treated patients increased in almost all classes of medication. At discharge, 96.7% of patients received statins, 98.5% antithrombotics and 22.3% antidiabetics. LDL-C was significantly reduced during rehabilitation — on average by 21.3 mg/dl (0.55 mmol/l). 41.9% of the patients achieved the LDL-C target value.

Conclusion

The results show that the optimization of secondary drug prevention in the outpatient sector must be continued unconditionally and consistently.

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Author information

Authors and Affiliations

  1. Curschmann Klinik, Rehabilitationskrankenhaus für Kardiologie, Angiologie und Diabetologie, Akademisches Lehrkrankenhaus der Universität zu Lübeck, Saunaring 6, 23669, Timmendorfer Strand, Deutschland

    Bernhard Schwaab

  2. Medizinische Klinik B, Herzzentrum Ludwigshafen und Institut für Klinische Pharmakologie, Technische Universität Dresden, Dresden, Deutschland

    Uwe Zeymer

  3. Medizinische Abteilung, MSD Sharp & Dohme GmbH, Haar, Deutschland

    Christina Jannowitz

  4. Institut für Klinische Pharmakologie, Technische Universität Dresden, Dresden, Deutschland

    David Pittrow

  5. Medizinische Klinik B, Herzzentrum Ludwigshafen und Stiftung IHF — Institut für Herzinfarktforschung, Ludwigshafen/Rhein, Deutschland

    Anselm Gitt

Authors
  1. Bernhard Schwaab
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  2. Uwe Zeymer
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  3. Christina Jannowitz
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  4. David Pittrow
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  5. Anselm Gitt
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Corresponding author

Correspondence to Bernhard Schwaab.

Additional information

This article is part of a supplement not sponsored by the industry.

Finanzierung der Studie

Die Studie PATIENT-CARE wurde durch MSD Sharp & Dohme GmbH, Haar, finanziert.

Teilnehmende Zentren

• Gollwitz-Meier-Klinik Bad Oeynhausen, Dr. Carsten Cordes

• Rehabilitationsklinik Elbe-Saale GmbH Barby, Dr. Yuri Bychkov

• Medclin Blieskastel Kliniken, Dr. Gunther Berg

• Klinik St. Irmingard GmbH Prien am Chiemsee, Dr. Inga Jahn

• Rehabilitationszentrum Oldenburg GmbH, Dr. Jochen Muke

• MedClin Fachklinik Rhein/Ruhr Essen, Dr. Dirk Bassenge

• Paracelsus-Harz-Klinik Quedlinburg, Prof. Dr. Axel Schlitt

• Drei-Burgen-Klinik Bad Münster am Stein, Dr. Ute Masius

• AOK Klinik Baden-Baden, Dr. Reiner Baumgärtner

• Klinik Höhenried gGmbH Bernried, Dr. Christina Bongarth

• Knappschafts-Klinik Bad Driburg, Dr. Gabriele Augsten

• Klinik Möhnesee, Dr. Rainer Schubmann

• Klinik Teutoburger Wald Bad Rothenfelde, Dr. Sebastian Hilgart

• MedClin Albert-Schweitzer-Klinik Königsfeld im Schwarzwald, Dr. Thomas Witt

• Klinik Bad Wörishofen, Prof. Jens Wagner

• Curschmann Klinik, Klinikgruppe Dr. Guth GmbH & Co. KG, Timmendorfer Strand, Prof. Bernhard Schwaab

• Herz-und-Kreislaufzentrum Rotenburg a. d. Fulda, Dr. Ralf Degenhardt

• HELIOS Rehaklinik Damp GmbH Ostseebad Damp, Dr. Norbert Henke

• Maternus Klinik Bad Oeynhausen, Hossain Sajid

• Dr. Lauterbach Klinik Bade Liebenstein, Dr. Jörg Kowalski

Interessenkonflikt

Prof. Bernhard Schwaab, Prof. Uwe Zeymer, Dr. Anselm Gitt und Prof. David Pittrow erhielten Honorar für Beratungsleistungen von MSD. Dr. Christina Jannowitz ist Mitarbeiterin von MSD.

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Schwaab, B., Zeymer, U., Jannowitz, C. et al. Verbesserte LDL-Cholesterin-Zielwerterreichung bei Patienten mit akutem Koronarsyndrom in der kardiologischen Rehabilitation: PATIENT-CARE-Register. MMW - Fortschritte der Medizin 161 (Suppl 5), 21–24 (2019). https://doi.org/10.1007/s15006-019-0742-y

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  • DOI: https://doi.org/10.1007/s15006-019-0742-y

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