Patienten, die von einer Trigeminus-Neuralgie geplagt werden, brauchen dringend eine wirksame Behandlung. Welche Basistherapie heute Standard ist und welche Optionen es für schwere, progrediente Verläufe gibt, wird im folgenden Beitrag dargestellt.
Literatur
Maarbjerg S, Di SG, Bendtsen L, Cruccu G (2017) Trigeminal neuralgia - diagnosis and treatment. Cephalalgia 37:648–657
Obermann M, Holle D, Katsarava Z (2011) Trigeminal neuralgia and persistent idiopathic facial pain. Expert Rev Neurother 11:1619–1629
Headache Classification Subcommittee of the International Headache Society (IHS) (2018) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38:1–211
Antonini G, Di PA, Cruccu G, Truini A, Morino S, Saltelli G, Romano A, Trasimeni G, Vanacore N, Bozzao A (2014) Magnetic resonance imaging contribution for diagnosing symptomatic neurovascular contact in classical trigeminal neuralgia: a blinded case-control study and meta-analysis. Pain 155:1464–1471
Maarbjerg S, Wolfram F, Gozalov A, Olesen J, Bendtsen L (2015) Significance of neurovascular contact in classical trigeminal neuralgia. Brain 138:311–319
Leal PR, Barbier C, Hermier M, Souza MA, Cristino-Filho G, Sindou M (2014) Atrophic changes in the trigeminal nerves of patients with trigeminal neuralgia due to neurovascular compression and their association with the severity of compression and clinical outcomes. J Neurosurg 120:1484–1495
Förderreuther S, Engelter S, Evers S, Paulus W, Tronnier V, Mitrovic N. (2012) Trigeminusneuralgie. Leitlinie der Deutschen Gesellschaft für Neurologie. https://www.dgn.org/leitlinien/2287-ll-58-2012-trigeminusneuralgie
Elsner F, Radbruch L, Gaertner J, Straub U, Sabatowski R (2006) [Efficacy of opioid analgesia at the superior cervical ganglion in neuropathic head and facial pain]. Schmerz 20:268–6
Zakrzewska JM, Chaudhry Z, Nurmikko TJ, Patton DW, Mullens EL (1997) Lamotrigine (lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. Pain 73:223–230
Lechin F, van der DB, Lechin ME, Amat J, Lechin AE, Cabrera A, Gomez F, Acosta E, Arocha L, Villa S, Jimenez V (1989) Pimozide therapy for trigeminal neuralgia. Arch Neurol 46:960–963
Wu CJ, Lian YJ, Zheng YK, Zhang HF, Chen Y, Xie NC, Wang LJ (2012) Botulinum toxin type A for the treatment of trigeminal neuralgia: results from a randomized, double-blind, placebo-controlled trial. Cephalalgia 32:443–450
Zhang H, Lian Y, Ma Y, Chen Y, He C, Xie N, Wu C (2014) Two doses of botulinum toxin type A for the treatment of trigeminal neuralgia: observation of therapeutic effect from a randomized, double-blind, placebo-controlled trial. J Headache Pain 15:65
Li S, Lian YJ, Chen Y, Zhang HF, Ma YQ, He CH, Wu CJ, Xie NC, Zheng YK, Zhang Y (2014) Therapeutic effect of Botulinum toxin-A in 88 patients with trigeminal neuralgia with 14-month follow-up. J Headache Pain 15:43
Zakrzewska JM, Palmer J, Morisset V, Giblin GM, Obermann M, Ettlin DA, Cruccu G, Bendtsen L, Estacion M, Derjean D, Waxman SG, Layton G, Gunn K, Tate S (2017) Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial. Lancet Neurol 16:291–300
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Ruscheweyh, R., Straube, A. Therapie der Trigeminus-Neuralgie. MMW - Fortschritte der Medizin 161, 52–56 (2019). https://doi.org/10.1007/s15006-019-0557-x
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DOI: https://doi.org/10.1007/s15006-019-0557-x