Sarkopenie wird als ein progressiver und generalisierter Verlust von Muskelmasse und Muskelfunktion verstanden. Damit ist eine erhöhte Wahrscheinlichkeit für z. B. Stürze, Frakturen, körperliche Behinderung und Mortalität verbunden. Was können Sie Ihren Patienten in Bezug auf Prävention und Therapie raten?
Literatur
McLean RR, Shardell MD, Alley DE, Cawthon PM, Fragala MS, Harris TB, Kenny AM, Peters KW, Ferrucci L, Guralnik JM, Kritchevsky SB, Kiel DP, Vassileva MT, Xue Q-L, Perera S, Studenski SA, Dam T-TL. Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J. Gerontol. A. Biol. Sci. Med. Sci. 2014;69(5):576–83.
Beaudart C, Zaaria M, Pasleau F, Reginster J-Y, Bruyère O. Health Outcomes of Sarcopenia: A Systematic Review and Meta-Analysis. PLoS One 2017;12(1):e0169548.
Malmstrom TK, Miller DK, Simonsick EM, Ferrucci L, Morley JE. SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J. Cachexia. Sarcopenia Muscle 2016;7(1):28–36.
Beaudart C, McCloskey E, Bruyère O, Cesari M, Rolland Y, Rizzoli R, Araujo de Carvalho I, Amuthavalli Thiyagarajan J, Bautmans I, Bertière MC, Brandi ML, Al-Daghri NM, Burlet N, Cavalier E, Cerreta F, Cherubini A, Fielding R, Gielen E, Landi F, Petermans J, Reginster JY, Visser M, Kanis J, Cooper C. Sarcopenia in daily practice: assessment and management. BMC Geriatr. 2016;16(1):1–10.
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M, Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) and the EG for E. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2018;(1):1–16.
Landi F, Liperoti R, Russo A, Giovannini S, Tosato M, Capoluongo E, Bernabei R, Onder G. Sarcopenia as a risk factor for falls in elderly individuals: Results from the ilSIRENTE study. Clin. Nutr. 2012;31(5):652–658.
Huo YR, Suriyaarachchi P, Gomez F, Curcio CL, Boersma D, Gunawardene P, Demontiero O, Duque G. Comprehensive nutritional status in sarco-osteoporotic older fallers. J. Nutr. Heal. Aging 2015;19(4):474–480.
Peterson MD, Sen A, Gordon PM. Influence of resistance exercise on lean body mass in aging adults: a meta-analysis. Med. Sci. Sports Exerc. 2011;43(2):249–58.
Papa E V., Dong X, Hassan M. Resistance training for activity limitations in older adults with skeletal muscle function deficits: A systematic review. Clin. Interv. Aging 2017;12:955–961.
Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA, Evans WJ. High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA 1990;263(22):3029–34.
Corbett DB, Rejeski WJ, Tudor-Locke C, Glynn NW, Kritchevsky SB, McDermott MM, Church TS, Fielding RA, Gill TM, King AC, Miller ME, Chen H, Pahor M, Manini TM. Social Participation Modifies the Effect of a Structured Physical Activity Program on Major Mobility Disability Among Older Adults: Results From the LIFE Study. Journals Gerontol. Ser. B 2017;00(00):1–13.
Corcoran MP, Nelson ME, Sacheck JM, Reid KF, Kirn D, Fielding RA, Folta SC. Recruitment of mobility limited older adults into a facility-led exercise-nutrition study: The effect of social involvement. Gerontologist 2016;56(4):669–676.
Peters A. The selfish brain: Competition for energy resources. Am. J. Hum. Biol. 2011;23(1):29–34.
Cederholm T, Jensen GL, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, Baptista G, Barazzoni R, Blaauw R, Coats A, Crivelli A, Evans DC, Gramlich L, Fuchs-Tarlovsky V, Keller H, Llido L, Malone A, Mogensen KM, Morley JE, Muscaritoli M, Nyulasi I, Pirlich M, Pisprasert V, de van der Schueren MAE, Siltharm S, Singer P, Tappenden K, Velasco N, Waitzberg D, Yamwong P, Yu J, Van Gossum A, Compher C, GLIM Core Leadership Committee, GLIM Working Group. GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community. Clin. Nutr. 2018. doi:https://doi.org/10.1016/j.clnu.2018.08.002.
Ikizler TA, Cano NJ, Franch H, Fouque D, Himmelfarb J, Kalantar-Zadeh K, Kuhlmann MK, Stenvinkel P, Terwee P, Teta D, Wang AYM, Wanner C. Prevention and treatment of protein energy wasting in chronic kidney disease patients: A consensus statement by the International Society of Renal Nutrition and Metabolism. Kidney Int. 2013;84(6):1096–1107.
Perry HM, Horowitz M, Morley JE, Patrick P, Vellas B, Baumgartner R, Garry PJ. Longitudinal changes in serum 25-hydroxyvitamin D in older people. Metabolism. 1999;48(8):1028–32.
Nieschlag E. Current topics in testosterone replacement of hypogonadal men. Best Pract. Res. Clin. Endocrinol. Metab. 2015;29(1):77–90.
Crawford JC, Johnston MA, Hancock ML, Small SG, Taylor RP, Dalton JT, Steiner MS. Enobosarm, a selective androgen receptor modulator (SARM), increases lean bodymass (LBM) in advanced nsclc patients; updated results of two pivotal, international phase 3 trials. Support. care cancer 2014;22(1 SUPPL. 1):S30–S31.
Crawford J, Prado CMM, Johnston MA, Gralla RJ, Taylor RP, Hancock ML, Dalton JT. Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials). Curr. Oncol. Rep. 2016;18(6). doi:https://doi.org/10.1007/s11912-016-0522-0.
Rooks D, Praestgaard J, Hariry S, Laurent D, Petricoul O, Perry RG, Lach-Trifilieff E, Roubenoff R. Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study. J. Am. Geriatr. Soc. 2017;65(9):1988–1995.
Becker C, Lord SR, Studenski SA, Warden SJ, Fielding RA, Recknor CP, Hochberg MC, Ferrari SL, Blain H, Binder EF, Rolland Y, Poiraudeau S, Benson CT, Myers SL, Hu L, Ahmad QI, Pacuch KR, Gomez E V, Benichou O, STEADY Group. Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial. lancet. Diabetes Endocrinol. 2015;3(12):948–57.
Band MM, Sumukadas D, Struthers AD, Avenell A, Donnan PT, Kemp PR, Smith KT, Hume CL, Hapca A, Witham MD. Leucine and ACE inhibitors as therapies for sarcopenia (LACE trial): study protocol for a randomised controlled trial. Trials 2018;19(1):6.
Pötsch MS, Tschirner A, Palus S, von Haehling S, Doehner W, Beadle J, Coats AJS, Anker SD, Springer J. The anabolic catabolic transforming agent (ACTA) espindolol increases muscle mass and decreases fat mass in old rats. J. Cachexia. Sarcopenia Muscle 2014;5(2):149–158.
Sumukadas D, Witham MD, Struthers AD, McMurdo MET. Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial. CMAJ 2007;177(8):867–74.
Morley JE. Pharmacologic Options for the Treatment of Sarcopenia. Calcif. Tissue Int. 2016;98(4):319–333.
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Ferrari, U., Drey, M. Sarkopenie: Wie kommt der Patient wieder zu Kräften?. MMW - Fortschritte der Medizin 161, 45–48 (2019). https://doi.org/10.1007/s15006-019-0455-2
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DOI: https://doi.org/10.1007/s15006-019-0455-2