Durch die weltweit zunehmende Prävalenz der Adipositas erkranken immer mehr Menschen an einer nichtalkoholischen Fettlebererkrankung (NAFLD). Bei ca. 30% entwickelt sich daraus eine nichtalkoholische Steatohepatitis (NASH). Wird diese nicht rechtzeitig erkannt und behandelt, drohen irreversible Schäden bis hin zu Karzinomen.
Literatur
Reccia I et al., Non-alcoholic fatty liver disease: A sign of systemic disease. Metabolism, 2017 Jul; 72: 94–108.
Roeb E et al., S2k Guideline non-alcoholic fatty liver disease. Z Gastroenterol. 2015 Jul; 53 (7): 668–723.
Caligiuri A et al., Molecular pathogenesis of NASH. Int J Mol Sci. 2016 Sep 20; 7 (9); 1–34.
Machado MV et al., Pathogenesis of non-alcoholic steatohepatitis. Gastroenterology. 2016 Jun; 150(8): 1769–77.
Oh H et al., Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment. Clin Mol Hepatol. 2016 Sep; 22(3): 327–335.
EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. EASL, EASD and EASO. J Hepatology 2016; 64: 1388 – 1402.
Vilar-Gomez E et al., Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015; 149(2):367–78.
Sanyal AJ et al., Pioglitazone, vitamin E, or placebo for non-alcoholic steatohepatitis. N Engl J Med. 2010; 362(18): 1675–85.
Armstrong MJ et al., Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet. 2016; 387: 679–90.
Neuschwander-Tetri BA et al., Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. NASH Clinical Research Network. Lancet. 2015; 385: 956–65.
Ratziu V et al., GOLDEN-505 Investigator Study Group. Elafibranor, an agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Gastroenterology. 2016; 150(5):1147–1159.
Friedman SL et al., A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis. Hepatology. 2017 Aug.
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Konturek, P.C. Neue und bewährte Therapieansätze bei NASH. MMW - Fortschritte der Medizin 160, 50–54 (2018). https://doi.org/10.1007/s15006-018-0292-8
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DOI: https://doi.org/10.1007/s15006-018-0292-8