Skip to main content
Log in

Immer besser im Griff

Die Rheumatoide Arthritis

Rheumatoid arthritis

  • FORTBILDUNG . ÜBERSICHT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

Zusammenfassung

Bei der Rheumatoiden Arthritis handelt es sich um eine chronische Gelenkentzündung mit destruierendem Charakter. Sie kann bereits im Jugendalter beginnen, aber auch im Senium sind Neuerkrankungen möglich. Es handelt sich um eine Autoimmunerkrankung, die nicht nur Gelenke, sondern auch innere Organe betreffen kann. Eine frühe Diagnose und eine rechtzeitige Therapie können die Prognose deutlich verbessern.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Westhoff G, Schneider M, Raspe H et al. Advance and unmet need of health care for patients with rheumatoid arthritis in the German population—results from the German Rheumatoid Arthritis Population Survey (GRAPS). Rheumatology. 2009;48:650–7; https://doi.org/10.1093/rheumatology/kep045

    Article  PubMed  Google Scholar 

  2. Guthrie KA, Dugowson CE, Voigt LF et al. Does pregnancy provide vaccine-like protection against rheumatoid arthritis? Arthritis Rheum. 2010;62:1842–8; https://doi.org/10.1002/art.27459

    PubMed  PubMed Central  Google Scholar 

  3. Kallberg H, Ding B, Padyukov L et al. Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke. Ann Rheum Dis. 2011;70:508–11; https://doi/10.1136/ard.2009.120899

    Article  PubMed  Google Scholar 

  4. Svendsen AJ, Junker P, Houen G et al. Incidence of Chronic Persistent Rheumatoid Arthritis and the Impact of Smoking: A Historical Twin Cohort Study. Arthritis Care Res. 2017;69:616–24; https://doi/10.1002/acr.22987

    Article  Google Scholar 

  5. Sundstrom B, Johansson I, Rantapaa-Dahlqvist S. Interaction between dietary sodium and smoking increases the risk for rheumatoid arthritis: results from a nested case-control study. Rheumatology. 2015;54: 487–93; https://doi/10.1093/rheumatology/keu330

    Article  PubMed  Google Scholar 

  6. de Hair MJ, Landewe RB, van de Sande MG et al. Smoking and overweight determine the likelihood of developing rheumatoid arthritis. Ann Rheum Dis. 2013;72:1654–8; https://doi/10.1136/annrheumdis-2012-202254

    Article  PubMed  Google Scholar 

  7. Stolt P, Yahya A, Bengtsson C et al. Silica exposure among male current smokers is associated with a high risk of developing ACPA-positive rheumatoid arthritis. Ann Rheum Dis. 2010;69:1072–6; https://doi/10.1136/ard.2009.114694

    Article  CAS  PubMed  Google Scholar 

  8. Di Giuseppe D, Wallin A, Bottai M et al. Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women. Ann Rheum Dis. 2014;73:1949–53; https://doi/10.1136/annrheumdis-2013-203338

    Article  PubMed  Google Scholar 

  9. Jin Z, Xiang C, Cai Q et al. Alcohol consumption as a preventive factor for developing rheumatoid arthritis: a dose-response meta-analysis of prospective studies. Ann Rheum Dis. 2014;73:1962–7; https://doi/10.1136/annrheumdis-2013-203323

    Article  PubMed  Google Scholar 

  10. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New Engl J Med. 2011;365:2205–19; https://doi.org/10.1056/NEJMra1004965

    Article  CAS  PubMed  Google Scholar 

  11. England BR, Thiele GM, Mikuls TR. Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis. Curr Opin Rheumatol. 2017;29:57–64; https://doi.org/10.1097/BOR.0000000000000356

    Article  CAS  PubMed  Google Scholar 

  12. Mikuls TR, Payne JB, Yu F et al. Periodontitis and Porphyromonas gingivalis in patients with rheumatoid arthritis. Arthritis Rheumatol 2014;66:1090–100; https://doi.org/10.1002/art.38348

    Article  PubMed  PubMed Central  Google Scholar 

  13. Maradit-Kremers H, Nicola PJ, Crowson CS et al. Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum. 2005;52:722–32; https://doi.org/10.1002/art.20878

    Article  PubMed  Google Scholar 

  14. Ranganath VK, Elashoff DA, Khanna D et al. Age adjustment corrects for apparent differences in erythrocyte sedimentation rate and C-reactive protein values at the onset of seropositive rheumatoid arthritis in younger and older patients. J Rheumatol. 2005;32:1040–2

    PubMed  Google Scholar 

  15. Nell VP, Machold KP, Stamm TA et al. Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis. 2005;64:1731–6; https://doi.org/10.1136/ard.2005.035691

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Schellekens GA, Visser H, de Jong BA et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000; 43:155–63; https://doi.org/10.1002/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3

    Article  CAS  PubMed  Google Scholar 

  17. Rantapaa-Dahlqvist S, de Jong BA, Berglin E et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003;48:2741–9; https://doi.org/10.1002/art.11223

    Article  PubMed  Google Scholar 

  18. De Rycke L, Peene I, Hoffman IE et al. Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann Rheum Dis. 2004;63:1587–93; https://doi.org/10.1136/ard.2003.017574

    Article  PubMed  PubMed Central  Google Scholar 

  19. Kellner H, Schmidt W, Rau R. Imaging procedures in rheumatology. Differential diagnosis using various imaging procedures in rheumatoid arthritis (RA). Z Rheumatol. 2005;64:553–6; https://doi.org/10.1007/s00393-005-0720-x

    Article  CAS  PubMed  Google Scholar 

  20. Aletaha D, Neogi T, Silman AJ et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569–81; https://doi.org/10.1002/art.27584

    Article  PubMed  Google Scholar 

  21. Smolen JS, Landewe R, Bijlsma J et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76:960–77; https://doi.org/10.1136/annrheumdis-2016-210715

    Article  PubMed  Google Scholar 

  22. Combe B, Landewe R, Daien CI et al. 2016 update of the EULAR recommendations for the management of early arthritis. Ann Rheum Dis. 2017;76: 948–59,; https://doi.org/10.1136/annrheumdis-2016-210602

    Article  PubMed  Google Scholar 

  23. Kruger K, Wollenhaupt J, Albrecht K et al. [German 2012 guidelines for the sequential medical treatment of rheumatoid arthritis. Adapted EULAR recommendations and updated treatment algorithm]. Z Rheumatol. 2012;71:592-603; https://doi.org/10.1007/s00393-012-1038-0

    Article  CAS  PubMed  Google Scholar 

  24. Braun J, Kay J. The safety of emerging biosimilar drugs for the treatment of rheumatoid arthritis. Expert Opin Drug Saf. 2017;16:289–302; https://doi.org/10.1080/14740338.2017.1273899

    Article  CAS  PubMed  Google Scholar 

  25. Taylor PC, Keystone EC, van der Heijde D et al. Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis. New Eng J Med. 2017; 376: 652–62; https://doi.org/10.1056/NEJMoa1608345

    Article  CAS  PubMed  Google Scholar 

  26. Singh JA, Hossain A, Mudano AS et al. Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2017;5: CD012657; https://doi.org/10.1002/14651858.CD012657

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gernot Keyßer.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Keyßer, G., Schäfer, C. Die Rheumatoide Arthritis. MMW - Fortschritte der Medizin 160, 50–58 (2018). https://doi.org/10.1007/s15006-018-0001-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-018-0001-7

Keywords

Navigation