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TAF statt TDF

Neue Therapie schont die Niere

New therapy preservers the kidney

  • FORTBILDUNG . ÜBERSICHT
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MMW - Fortschritte der Medizin Aims and scope

Tenofovir ist als ein zentraler Baustein der HIV-Therapie sehr häufig im Einsatz. Doch die bisher verwendete Substanz führte nicht selten zu Nierenfunktionsstörungen. Ändert sich dies mit der Einführung eines neueren Präparats?

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Literatur

  1. Nishijima T et al. Long-term exposure to tenofovir continuously decrease renal function in HIV-1-infected patients with low body weight: results from10 years of follow-up, AIDS 2014, 28:1903–1910

    Article  CAS  PubMed  Google Scholar 

  2. Nelson M, Katlama C, Montaner JS, et al. The safety of TDF for the treatment of HIV infection in adults: the first 4 years. AIDS 2007; 21:1273–81.

    Article  CAS  PubMed  Google Scholar 

  3. Gallant JE, Winston J, DeJesus E, et al. The 3- year renal safety of a tenofovir disoproxil fumarate vs. a thymidine analogue- containing regime in antiretroviral- naive patients. AIDS 2008, 22:2155–2163.

    Article  CAS  PubMed  Google Scholar 

  4. Casado, Jose et al.: Prevalence and significance of proximal renal tubular abnormalities in HIV infected patients receiving tenofovir. Aids 2016, 30: 231–239

    Article  CAS  PubMed  Google Scholar 

  5. Martorell C, et al. Efficacy and Safety of Co-formulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide in Geriatric Adults with Renal Impairment, 7th International Workshop on HIV & Aging, September 26-27, 2016, Washington DC

  6. Raffi F, et al. HIV Drug Therapy Glasgow 2016. O125.

  7. Sax P, et al. Lancet 2014

  8. Ruane P, et al. J Acquir Immune Defic Syndr. 2013;63:449.

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur

  • Gallant Joel E, Eric S Daar, Raffi, Francois et al. Efficacy and safety of tenofovir alafenamide versus tenofovir disoproxil fumarate given as fixed-dose combinations containing emtricitabine as backbones for treatment of HIV-1 infection in virologically suppressed adults: a randomised, double-blind, active-controlled phase 3 trial. Lancet HIV 2016; 3: e158–65

    Article  PubMed  Google Scholar 

  • Gallant Joel E, Brunetta Jason, Crofoot Gordon et al. Efficacy and Safety of Switching to a Single-Tablet Regimen of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in HIV-1/Hepatitis B-Coinfected Adults. J Acquir Immune Defic Syndr 2016; 73:294–298

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gallant JE, Parish MA, et al. Tenofovir and changes in renal function:reply to Gupta (letter). Clin Infect Dis 2005; 41:571

    Article  Google Scholar 

  • Gaur Aditya H, Kizito Hilda, Prasitsueubsai Wasana et al. Safety, efficacy, and pharmacokinetics of a single-tablet regimen containing elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in treatment-naïve, HIV-infected adolescents: a single-arm, open-label trial. Lancet HIV 2016, Published online October 17,2016 hhtp://dx.doi.org/10.1016/S2352-3018(16)30121-7

  • Huhn Gregory D, Tebas Pablo, Galland Joel et al. A Randomized, Opel-Label Trial to Evaluate Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Darunavir in Treatment-Experienced HIB-1-Infected Adults. J Acquir Immune Defic Syndr, Volume 74,Number 2, February 1,2017

  • Mills Anthony, Arribas Jose R, Andrade-Villanueva Jaime et al. Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomized active-controlled, multicentre, open-label, phase 3, non-inferiority study. Lancet Infect Dis 2015, Published online, November 2, 2015; http://dx.doi.org/10.1016/ S1473-3099(15)00348-5

  • Post Frank A, Tebas Pablo, Clarke Amanda et al. Switching to Tenofovir Alafenamide, Coformulated With Elvitegravir, Cobicistat, and Emtricitabine, in HIV-Infected Adults With Renal Impairment: 96-Week Results From a Single-Arm, Multicenter, Open-Label Phase 3 Study. J Acquir Immune Defic Syndr; Volume 74; Number 2, February 1, 2017

  • Pozniak Anton, Arribad Jose R, Gathe Joseph et al. Switching to Tenofovir Alafenamide, Coformulataed With Elvitegravir, Cobicistat, and Emtricitabine, in HIV-Infected Patients With Renal Impairment: 48-Week Results From a Single-Arm, Multicenter, Open-Label Phase 3 Study. J Acquir Immune Defic Syndr; Volume 71; Number 5, April 15,2016

  • Raffi F et al. Long-term (96-week) Efficacy and Safety After Switching from Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) in HIV-infected, Virologically Suppressed Adults, JAIDS Journal of Acquired Immune Deficiency Syndromes Publish Ahead of Print

  • Rieke, A. HIV und Niere in www.HIVBUCH.de, 2016; 552- 565

  • Sax Paul E, Wohl, David, Yin Michael T et al. Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomized, double-blind, phase 3, non-inferiority trials. Lancet 2015;385:2606–15

    Article  CAS  PubMed  Google Scholar 

  • Wohl David, Oka Shinichi, Clumeck Nathan et al. A Randomized, Double-Blind Comparison of Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate, Each Coformulated With Elvitegravir, Cobicistat, and Emtricitabine for Initial HIV-1 Treatment: Week 96 Results. J Acquir Immune Defic Syndr 2016; 72:58–64

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Ansgar Rieke.

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Rieke, A. Neue Therapie schont die Niere. MMW - Fortschritte der Medizin 159 (Suppl 2), 27–31 (2017). https://doi.org/10.1007/s15006-017-9731-1

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  • DOI: https://doi.org/10.1007/s15006-017-9731-1

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