Skip to main content
SpringerLink
Log in

Gegen Herpes Zoster impfen

Schutz vor einer Zeitbombe

Protection from a dormant time bomb: The development of effective vaccines against herpes zoster

  • FORTBILDUNG . ÜBERSICHT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

Plötzlich einschießende Schmerzen, die an elektrische Schläge erinnern — Gürtelrose ist eine Qual. Um sich davor zu schützen, steht in Deutschland ein Lebendimpfstoff zur Verfügung. Die Zulassung eines Totimpfstoffes, der auch für immunsupprimierte Personen geeignet ist, wird für 2018 erwartet.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Wutzler P, Farber I, Wagenpfeil S, Bisanz H, Tischer A. Seroprevalence of varicella-zoster virus in the German population. Vaccine. 2001;20(1-2):121–124.

    Article  CAS  PubMed  Google Scholar 

  2. Robert Koch Institut. Stellungnahme der Ständigen Impfkommission (STIKO): Evaluation der Varizellen-Impfempfehlung durch die STIKO. Epidemiologisches Bulletin. 2013;7. Januar 2013(1).

  3. Cohen JI. Clinical practice: Herpes zoster. N Engl J Med. 2013;369(3):255–263.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Simberkoff MS, Arbeit RD, Johnson GR, Oxman MN, Boardman KD, Williams HM, et al. Safety of herpes zoster vaccine in the shingles prevention study: a randomized trial. Ann Intern Med. 2010;152(9):545–554.

    Article  PubMed  Google Scholar 

  5. Ultsch B, Siedler A, Rieck T, Reinhold T, Krause G, Wichmann O. Herpes zoster in Germany: quantifying the burden of disease. BMC Infect Dis. 2011;11:173.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Hope-Simpson RE. The Nature of Herpes Zoster: A Long-Term Study and a New Hypothesis. Proc R Soc Med. 1965;58:9–20.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Horn J, Karch A, Damm O, Kretzschmar ME, Siedler A, Ultsch B, et al. Current and future effects of varicella and herpes zoster vaccination in Germany - Insights from a mathematical model in a country with universal varicella vaccination. Hum Vaccin Immunother. 2016;12(7):1766–1776.

    PubMed  PubMed Central  Google Scholar 

  8. Doan HQ, Ung B, Ramirez-Fort MK, Khan F, Tyring SK. Zostavax: a subcutaneous vaccine for the prevention of herpes zoster. Expert Opin Biol Ther. 2013;13(10):1467–1477.

    Article  CAS  PubMed  Google Scholar 

  9. Hales CM, Harpaz R, Ortega-Sanchez I, Bialek SR, Centers for Disease C, Prevention. Update on recommendations for use of herpes zoster vaccine. MMWR Morb Mortal Wkly Rep. 2014;63(33):729–731.

    PubMed  Google Scholar 

  10. Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005;352(22):2271–2284.

    Article  CAS  PubMed  Google Scholar 

  11. Schmader KE, Johnson GR, Saddier P, Ciarleglio M, Wang WW, Zhang JH, et al. Effect of a zoster vaccine on herpes zoster-related interference with functional status and health-related quality-of-life measures in older adults. J Am Geriatr Soc. 2010;58(9):1634–1641.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Schmader KE, Levin MJ, Gnann JW, Jr., McNeil SA, Vesikari T, Betts RF, et al. Efficacy, safety, and tolerability of herpes zoster vaccine in persons aged 50-59 years. Clin Infect Dis. 2012;54(7):922–928.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Levin MJ, Schmader KE, Pang L, Williams-Diaz A, Zerbe G, Canniff J, et al. Cellular and Humoral Responses to a Second Dose of Herpes Zoster Vaccine Administered 10 Years After the First Dose Among Older Adults. J Infect Dis. 2016;213(1):14–22.

    Article  PubMed  Google Scholar 

  14. Robert Koch Institut. Empfehlungen der Ständigen Impfkommission (STIKO) am Robert Koch-Institut — 2016/2017. Epidemiologisches Bulletin. 2016.

  15. Lal H, Cunningham AL, Godeaux O, Chlibek R, Diez-Domingo J, Hwang SJ, et al. Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015;372(22):2087–2096.

    Article  PubMed  Google Scholar 

  16. Cunningham AL, Lal H, Kovac M, Chlibek R, Hwang SJ, Diez-Domingo J, et al. Efficacy of the Herpes Zoster Subunit Vaccine in Adults 70 Years of Age or Older. N Engl J Med. 2016;375(11):1019–1032.

    Article  CAS  PubMed  Google Scholar 

  17. Stadtmauer EA, Sullivan KM, Marty FM, Dadwal SS, Papanicolaou GA, Shea TC, et al. A phase 1/2 study of an adjuvanted varicella-zoster virus subunit vaccine in autologous hematopoietic cell transplant recipients. Blood. 2014;124(19):2921–2929.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Schiffner-Rohe J, Jow S, Lilie HM, Köster I, Schubert I. Herpes zoster in Deutschland - Eine retrospektive Analyse von GKV-Daten. MMW Fortschr Med Originalien. 2009;IV/2009(151):193–197.

    Google Scholar 

  19. Hillebrand K, Bricout H, Schulze-Rath R, Schink T, Garbe E. Incidence of herpes zoster and its complications in Germany, 2005-2009. J Infect. 2015;70(2):178–186.

    Article  PubMed  Google Scholar 

  20. https://www.rki.de/DE/Content/Infekt/EpidBull/Merkblaetter/Ratgeber_Varizellen.html, letzter Zugriff am 12.10.20162

Download references

Author information

Authors and Affiliations

  1. Klinikum der Universität München, Institut für Allgemeinmedizin, Pettenkoferstr. 8a, D-80336, München, Deutschland

    Jörg Schelling &  Ina-Maria Rückert-Eheberg MPH

  2. Klinik für Geriatrie, Alexianer Krefeld GmbH, Krefeld, Deutschland

    Andreas H. Leischker M.A.

Authors
  1. Jörg Schelling
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ina-Maria Rückert-Eheberg MPH
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andreas H. Leischker M.A.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jörg Schelling.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schelling, J., Rückert-Eheberg, IM. & Leischker, A.H. Schutz vor einer Zeitbombe. MMW - Fortschritte der Medizin 159, 46–48 (2017). https://doi.org/10.1007/s15006-017-9707-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-017-9707-1

Keywords

Search

Navigation