Skip to main content
Log in

Erst weitläufig verordnet, dann in Verruf geraten

Renaissance der Hormontherapie

The renaissance of hormonal therapy

  • FORTBILDUNG . SCHWERPUNKT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

In den 1980er-Jahren wurden Frauen in den Wechseljahren Hormone z. T. recht unkritisch verordnet. 2002 kam diese Therapie dann nach der Publikation der WHI-Studie in Verruf. Wie ist der aktuelle Wissensstand zu Nutzen und Risiken?

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. Stuenkel CA, Davis SR, Gompel A, et al. Treatment of symptoms of the menopause: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2015; 100: 3975–4011.

    Article  CAS  PubMed  Google Scholar 

  2. Santen RJ, Stuenkel CA, Burger HG, Manson JE. Competency in menopause management: whither goest the internist? J Womens Health 2014; 23: 281–5.

    Article  Google Scholar 

  3. Weidner, Beckermann, MJ. Nicht nur eine Frage der hormonellen Situation. Dtsch Arztebl 2016; 113:2101–2106

    Google Scholar 

  4. Weidner K, Richter J, Bittner A, Stöbel-Richter Y, Brähler E: Klimakterische Beschwerden über die Lebensspanne? Ergebnisse einer repräsentativen Umfrage in der deutschen Allgemeinbevölkerung. Psychother Psychosom Med 2012; 62: 266–75.

    Article  Google Scholar 

  5. Freedman RR. Physiology of hot flashes. Am J Hum Biol. 2001 Aug; 13(4):453–64.

    Article  CAS  PubMed  Google Scholar 

  6. Sarrel P1, Portman D, Lefebvre P, Lafeuille MH, Grittner AM, Fortier J, Gravel J, Duh MS, Aupperle PM. Incremental direct and indirect costs of untreated vasomotor symptoms. Menopause. 2015 Mar;22(3):260–6.

    Article  PubMed  Google Scholar 

  7. Gesundheitsreport der Techniker Krankenkasse 2011

  8. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002; 288:321–333.

    Article  CAS  PubMed  Google Scholar 

  9. Rossouw JE1, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, Ko M, LaCroix AZ, Margolis KL, Stefanick ML. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA. 2007;297(13):1465–77

    Article  CAS  PubMed  Google Scholar 

  10. Rossouw JE1, Manson JE, Kaunitz AM, Anderson GL. Lessons learned from the Women’s Health Initiative trials of menopausal hormone therapy. Obstet Gynecol. 2013;121(1):172–6.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Stuenkel CA, Gass ML, Manson JE, et al. A decade after the women’s health initiative—the experts do agree. J Clin Endocrinol Metab. 2012;97:2617–2618.

    Article  CAS  PubMed  Google Scholar 

  12. de Villiers TJ, Gass ML, Haines CJ, et al. Global consensus statement on menopausal hormone therapy. Maturitas. 2013;74:391–392

    Article  PubMed  Google Scholar 

  13. Birkhauser M, Hadji P, Imthurn B, Mueck AO, Neulen J, Thaler CJ, Wiegratz I, Wildt L. 10 Jahre Women’s Health Initiative (WHI) — was haben wir gelernt? Frauenarzt. 2013;54:346–356.

    Google Scholar 

  14. Manson JE, Kaunitz AM. Menopause management — Getting clinical care back on track. N Engl J Med 2016; 374: 803–806.

    Article  PubMed  Google Scholar 

  15. Hsieh E, Nunez-Smith M, Henrich JB. Needs and priorities in women’s health training: perspectives from an internal medicine residency program. J Womens Health (Larchmt) 2013; 22: 667–72.

    Article  Google Scholar 

  16. Mueck AO. Anwendungsempfehlungen zur Hormonsubstitution im Klimakterium und Postmenopause. Frauenarzt 2015; 56: 657–659.

    Google Scholar 

  17. Bassuk SS, Manson JE. The timing hypothesis: Do coronary risks of menopausal hormone therapy vary by age or time since menopause onset? Metabolism. 2016 May;65(5):794–803.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Hodis HN, Mack WJ, Shoupe D, Azen SP, Stanczyk FZ, Hwang-Levine J, Budoff MJ, Henderson VW. Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradioltesting the menopausal hormone timing hypothesis. Menopause. 2015 Apr;22(4):391–401.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Olié V, Canonico M, Scarabin PY. Risk of venous thrombosis with oral versus transdermal estrogen therapy among postmenopausal women. Curr Opin Hematol. 2010;17(5):457–463.

    Article  PubMed  Google Scholar 

  20. Sweetland S, Beral V, Balkwill A et al. Venous thromboembolism risk in relation to use of different types of postmenopausal hormone therapy in a large prospective study. J. Thromb. Haemost. 10, 2277–2286 (2012).

    Article  CAS  PubMed  Google Scholar 

  21. Birkhaeuser M, Hadji P, Imthurn B, Mueck AO, Neulen J, Thaler CJ, Wiegratz I, Wildt L. Postmenopausale Hormonsubstitution und Thrombo-Embolierisiko: Unterschied zwischen oraler und transdermaler Applikation? Gyne 04/2014

  22. Fournier A, Berrino F, Clavel-Chapelon F. Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study. Breast Cancer Res Treat. 2008;107:103–111.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Corinna Mann.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mann, C., Rogenhofer, N., Mahner, S. et al. Renaissance der Hormontherapie. MMW - Fortschritte der Medizin 159, 39–42 (2017). https://doi.org/10.1007/s15006-017-9705-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-017-9705-3

Keywords

Navigation