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Dauerhafte Heilung bei vielen Patienten

Das ist neu in der Therapie der Hepatitis C

The news in hepatitis C therapy

  • FORTBILDUNG . ÜBERSICHT
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MMW - Fortschritte der Medizin Aims and scope

Zusammenfassung

Die Einführung der neuen direkt antiviral wirksamen Medikamente hat die Therapie der chronischen Hepatitis C revolutioniert. Dank dieser Entwicklung sind wir heute in der Lage, den überwiegenden Teil unserer Hepatitis-C-Patienten dauerhaft zu heilen. Für die tägliche Praxis ist daher eine gezielte Diagnostik bezüglich einer Hepatitis C von großer Bedeutung, um infizierte Patienten identifizieren und behandeln zu können.

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Literatur

  1. Webster DP, Klenermann P et al. Hepatitis C. Lancet. 2015;385:1124–35

    Article  PubMed  PubMed Central  Google Scholar 

  2. Blachier M, Leleu H et al. The burden of liver disease in Europe: A review of available epidemiological data. J Hepatol. 2013;58:593–608

    Article  PubMed  Google Scholar 

  3. Robert-Koch-Institut. Epidemiologisches Bulletin Nr. 29, 25. Juli 2016

  4. Thein HH, Yi Q, Dore GJ, Krahn MD: Estimation of stage-specific fibrosis progression rates in chronic hepatitis C virus infection: a meta-analysis and meta-regression. Hepatology. 2008;48:418–31

    Article  PubMed  Google Scholar 

  5. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132:2557–76

    Article  CAS  PubMed  Google Scholar 

  6. Ramos-Casals M, Zignego AL et al. Evidence-based recommendations on the management of extrahepatic manifestations of chronic hepatitis C virus infection. J Hepatol. 2017;66:1282–99

    Article  PubMed  Google Scholar 

  7. Smith DB, Bukh J et al. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. Hepatology. 2014;59:318–27

    Article  PubMed  Google Scholar 

  8. Messina JP, Humphreys I et al. Global distribution and prevalence of hepatitis C virus genotypes. Hepatology. 2015;61:77–87

    Article  PubMed  Google Scholar 

  9. Hüppe D, Zehnter E et al. Epidemiology of chronic hepatitis C in Germany - an analysis of 10,326 patients in hepatitis centres and outpatient units. Z Gastroenterol. 2008;46:34–44

    Article  PubMed  Google Scholar 

  10. De Luca A, Di Giambenedetto S et al. Two Distinct Hepatitis C Virus Genotype 1a Clades Have Different Geographical Distribution and Association With Natural Resistance to NS3 Protease Inhibitors. Open Forum Infect Dis. 2015;2 - https://doi.org/10.1093/ofid/ofv043

  11. Zimmermann R, Marcus U et al. A multicentre sero-behavioural survey for hepatitis B and C, HIV and HTLV among people who inject drugs in Germany using respondent driven sampling. BMC Public Health. 2014;14:845

    Article  PubMed  PubMed Central  Google Scholar 

  12. Schmidt AJ, Rockstroh JK et al. Trouble with bleeding: risk factors for acute hepatitis C among HIV-positive gay men from Germany — a case-control study. PloS one 2011;6:e17781

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Jansen K, Thamm M et al. High Prevalence and High Incidence of Coinfection with Hepatitis B, Hepatitis C, and Syphilis and Low Rate of Effective Vaccination against Hepatitis B in HIV-Positive Men Who Have Sex with Men with Known Date of HIV Seroconversion in Germany. PLoS One 2015;10:e0142515

    Article  PubMed  PubMed Central  Google Scholar 

  14. Hagan H, Jordan AE et al. Incidence of sexually transmitted hepatitis C virus infection in HIV-positive men who have sex with men. Aids. 2015;29:2335–45

    Article  PubMed  PubMed Central  Google Scholar 

  15. McFaul K, Maghlaoui A et al. Acute hepatitis C infection in HIV-negative men who have sex with men. J Viral Hepat. 2015;22:535–8

    Article  CAS  PubMed  Google Scholar 

  16. Sarrazin C, Berg T et al. Prophylaxis, Diagnosis and Therapy of Hepatitis C Virus (HCV) Infection: The German Guidelines on the Management of HCV Infection. Z Gastroenterol. 2010;48:289–351

    Article  CAS  PubMed  Google Scholar 

  17. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol. 2015;63:237–264

  18. Zeuzem S. Treatment options in hepatitis C — the current state of the art. Dtsch Arztebl Int. 2017;114:11–21

    PubMed  PubMed Central  Google Scholar 

  19. Lange CM, Jacobson IM et al. Emerging therapies for the treatment of hepatitis C. EMBO Mol Med. 2014;6:4–15

    Article  CAS  PubMed  Google Scholar 

  20. Sarrazin C, Hézode C et al. Antiviral strategies in hepatitis C virus infection. J Hepatol. 2012;56(Suppl 1):88–100

    Article  Google Scholar 

  21. Aktuelle Empfehlungen zur Therapie der chronischen Hepatitis C. www.dgvs.de/wissen-kompakt/leitlinien/leitlinien-der-dgvs/hepatitis-c

  22. Ioannou GN, Beste LA et al. Effectiveness of Sofosbuvir,Ledipasvir/Sofosbuvir, or Paritaprevir/Ritonavir/Ombitasvir and Dasabuvir Regimens forTreatment of Patients With Hepatitis C in the Veterans Affairs National Health Care System. Gastroenterology 2016;151:457–71

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Bruno S, Stroffolini T et al. Sustained virologhical response to interfreron-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study. Hepatology. 2007;45:579–87

    Article  CAS  PubMed  Google Scholar 

  24. Van der Meer AL, Veldt BJ et al. Association between sustained virological response and all-cause mortality among patients with chronic hepatitis c and advanced hepatic fibrosis. JAMA. 2012;308:2584–93

    Article  PubMed  Google Scholar 

  25. Kowdley KV, Gordon SC et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med. 2014;370:1879–88

    Article  PubMed  Google Scholar 

  26. Ferenci P, Bernstein D et al. ABT-450/r-ombitasvir and dasabuvir with or without ribavirin for HCV. N Engl J Med. 2014;370:1983–92

    Article  PubMed  Google Scholar 

  27. Welzel TM, Asselah T et al. Lancet Gastroenterol Hepatol. 2017 Apr 13. pii: S2468-1253(17)30071 7. doi: 10.1016/S2468-1253(17) 30071-7 (Epub ahead of print)

  28. Zeuzem S, Ghalib R et al. Grazoprevir-Elbasvir combination therapy for treatment-naive cirrhotic and noncirrhotic patients withchronic hepatitis C virus genotype 1, 4, or 6 infection: A randomizedtrial. Ann Intern Med. 2015;163:1–13

    Article  PubMed  Google Scholar 

  29. Zeuzem S, Dusheiko GM et al. Sofosbuvir and ribavirin in HCV genotypes 2 and 3. N Engl J Med. 2014;370:1993–2001

    Article  PubMed  Google Scholar 

  30. Feld JJ, Jacobson IM et al. Sofosbuvir and Velpatasvir for HCV Genotype 1, 2, 4, 5, and 6 infection. N Engl J Med. 2015;373:2599–607

    Article  CAS  PubMed  Google Scholar 

  31. Foster GR, Afdhal N et al. Sofosbuvir and Velpatasvir for HCV genotype 2 and 3 infection. N Engl J Med. 2015;373:2608–17

    Article  CAS  PubMed  Google Scholar 

  32. Sulkowski MS, Gardiner DF et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med. 2014;370:211–21

    Article  CAS  PubMed  Google Scholar 

  33. Bourlière M, Gordon SC et al. Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection. N Engl J Med. 2017;376:2134–46

    Article  PubMed  Google Scholar 

  34. Jacobson IM, Lawitz E et al. Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials. Gastroenterology. 2017;153:113–22

    Article  CAS  PubMed  Google Scholar 

  35. Forns X, Lee SS et al. Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial. Lancet Infect Dis. 2017;14. pii: S1473–3099(17)30496–6

    Google Scholar 

  36. Kwo PY, Poordad F et al. Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis. J Hepatol. 2017;67:263–71

    Article  CAS  PubMed  Google Scholar 

  37. Poordad F, Felizarta F et al. Glecaprevir and pibrentasvir for 12 weeks for hepatitis C virus genotype 1 infection and prior direct-acting antiviral treatment. Hepatology. 2017;66:389–97

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Nektarios Dikopoulos.

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This article is part of a supplement not sponsored by the industry.

INTERESSENKONFLIKTE

Die Autoren erklären, dass sie sich bei der Erstellung des Beitrages von keinen wirtschaftlichen Interessen leiten ließen. Sie legen folgende potenzielle Interessenkonflikte offen: Frau Dr. Backhus: Vortragshonorar der Firma Gilead; Prof. Dikopoulos: Vortragshonorare der Firmen Gilead, AbbVie und MSD. Prof. Dollinger: Vortrags- und Beratertätigkeit sowie Studiendurchführung für die Firmen Gilead, AbbVie, Merck, BMS und Janssen.

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Dikopoulos, N., Backhus, J. & Dollinger, M. Das ist neu in der Therapie der Hepatitis C. MMW - Fortschritte der Medizin 159 (Suppl 3), 43–52 (2017). https://doi.org/10.1007/s15006-017-9595-4

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  • DOI: https://doi.org/10.1007/s15006-017-9595-4

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