Bei therapieresistenter Depression könnte die transkranielle Gleichstromstimulation eine Behandlungsalternative darstellen. Wie funktioniert und wie wirkt sie? Ist sie eventuell auch eine Option für Schwangere mit Depressionen?
Literatur
Maeda F, Keenan JP, Pascual-Leone A. Interhemispheric asymmetry of motor cortical excitability in major depression as measured by transcranial magnetic stimulation. Br J Psychiatry 2000; 177: 169–173.
Nitsche MA. Modulation kortikaler Erregbarkeit beim Menschen durch transkranielle Gleichstromstimulation. Nervenarzt 2002; 73: 332–335.
Palm U, Keeser D, Schiller C, Fintescu Z, Reisinger E, Baghai TC, et al. Transcranial direct current stimulation in a patient with therapy-resistant major depression. World J Biol Psychiatry 2009; 10 (Pt 2): 632–635.
Keeser D, Padberg F, Reisinger E, Pogarell O, Kirsch V, Palm U, et al. Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) study. Neuroimage 2011; 55: 644–657.
Keeser D, Meindl T, Bor J, Palm U, Pogarell O, Mulert C, et al. Prefrontal transcranial direct current stimulation changes connectivity of resting state networks during fMRI. J Neurosci 2011; 26: 15284–15293.
Peña-Gómez C, Sala-Lonch R, Junqué C, Clemente IC, Vidal D, Bargalló N, Falcón C, Valls-Solé J, Pascual-Leone Á, Bartrés-Faz D. Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI. Brain Stimul 2012; 5: 252–263.
Loo CK, Sachdev P, Martin DM, Pigot M, Alonzo A, Malhi GS, et al. A double-Blind, sham-controlled trial of transcranial direct current stimulation for the treatment of depression. Int J Neuropsychopharmacol 2010; 13: 61–69.
Loo CK, Alonzo A, Martin DM, Mitchel PB, Galvez V, Sachdev P. Transcranial direct current stimulation for depression: 3-week, randomized, sham-controlled trial. Br J Psychiatry 2012; 200: 52–59.
Palm U, Schiller C, Fintescu Z, Obermeier M, Keeser D, Reisinger E, et al. Transcranial direct current stimulation in treatment resistant depression: a randomized double-blind, placebo-controlled study. Brain Stimul 2012; 5: 242–251.
Blumberger DM, Tran LC, Fitzgerald PB, Hoy KE, Daskalakis ZJ. A randomized double-blind sham-controlled study of transcranial direct current stimulation for treatment-resistant major depression. Front Psychiatry 2012; 3: 74.
Brunoni AR, Valiengo L, Baccaro A, Zanao TA, de Oliveira JF, Goulart A, et al. The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry 2013; 70: 893–891.
Bennabi D, Nicolier M, Monnin J, et al. Pilot study of feasibility of the effect of treatment with tDCS in patients suffering from treatment-resistant depression treated with escitalopram. Clinical Neurophysiology 2015; 126: 1185–1189.
Raimundo RJ, Uribe CE, Brasil-Neto JP. Lack of clinically detectable acute changes on autonomic or thermoregulatory functions in healthy subjects after transcranial direct current stimulation (tDCS). Brain Stimul 2012; 5: 196–200.
Rigonatti SP, Boggio PS, Myczkowski ML, Otta E, Fiquer JT, Ribeiro RB, Nitsche MA, Pascual-Leone A, Fregni F. Transcranial direct stimulation and fluoxetine for the treatment of depression. Eur Psychiatry 2008; 23: 74–76.
Lefaucheur JP et al. Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). In Vorbereitung.
Vigod S, Dennis CL, Daskalakis Z, Murphy K, Ray J, Oberlander T, Somerton S, Hussain-Shamsy N, Blumberger D. Transcranial direct current stimulation (tDCS) for treatment of major depression during pregnancy: study protocol for a pilot randomized controlled trial. Trials 2014; 15: 366.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Tschirdewahn, J., Vignaud, P., Pfeiffer, A. et al. Neue Therapieoption bei Depression: die transkranielle Gleichstromstimulation. MMW - Fortschritte der Medizin 157, 46–49 (2015). https://doi.org/10.1007/s15006-015-7540-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s15006-015-7540-y