Skip to main content
SpringerLink
Log in

Neue Vakzine mit zwei Influenza-B-Stämmen

Vierfach gegen Grippe: bald Standard?

Quadrivalent influenza vaccines

  • FORTBILDUNG_ÜBERSICHT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

Der klassische trivalente Grippeimpfstoff enthält – neben zwei Influenza-A-Subtypen – nur einen B-Stamm. Da die Vorhersagen, welche B-Linie in der nächsten Saison aktiv sein wird, nicht immer zutreffen, war die Entwicklung eines Vierfachimpfstoffes naheliegend. Für wen ist er empfehlenswert?

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Ambrose CS, Levin MJ. The rationale for quadrivalent influenza vaccines. Hum Vaccin Immunother. 2012;8: 81–88.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Belshe RB, Coelingh K, Ambrose CS, Woo JC, Wu X. Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarity. Vaccine. 2010;28:2149–2156.

    Article  CAS  PubMed  Google Scholar 

  3. Beran J, Peeters M, Dewé W, Raupachová J, Hobzová L, Devaster JM. Immunogenicity and safety of quadrivalent versus trivalent inactivated influenza vaccine: a randomized, controlled trial in adults. BMC Infect Dis. 2013;13:224.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Block SL, Falloon J, Hirschfield JA, Krilov LR, Dubovsky F, Yi T, Belshe RB. Immunogenicity and safety of a quadrivalent live attenuated influenza vaccine in children. Pediatr Infect Dis J. 2012;31:745–751.

    Article  PubMed  Google Scholar 

  5. Domachowske JB, Pankow-Culot H, Bautista M, Feng Y, Claeys C, Peeters M, Innis BL, Jain V. A randomized trial of candidate inactivated quadrivalent influenza vaccine versus trivalent influenza vaccines in children aged 3-17 years. J Infect Dis. 2013;207:1878–1887.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Eichner M, Schwehm M, Hain J, Uphoff H, Salzberger B, Knuf M, Schmidt-Ott R. 4Flu - an individual based simulation tool to study the effects of quadrivalent vaccination on seasonal influenza in Germany. BMC Infect Dis. 2014;14:365.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Glezen PW, Schmier JK, Kuehn CM, Ryan KJ, Oxford J. The burden of influenza B: a structured literature review. Am J Public Health. 2013;103:e43–51.

    Article  Google Scholar 

  8. Greenberg DP, Robertson CA, Noss MJ, Blatter MM, Biedenbender R, Decker MD. Safety and immunogenicity of a quadrivalent inactivated influenza vaccine compared to licensed trivalent inactivated influenza vaccines in adults. Vaccine. 2013;31:770–776.

    Article  CAS  PubMed  Google Scholar 

  9. Greenberg DP, Robertson CA, Landolfi VA, Bhaumik A, Senders SD, Decker MD. Safety and immunogenicity of an inactivated quadrivalent influenza vaccine in children 6 months through 8 years of age. Pediatr Infect Dis J. 2014;33:630–636.

    Article  PubMed  Google Scholar 

  10. Gutiérrez-Pizarraya A, Pérez-Romero P, Alvarez R, Aydillo TA, Osorio-Gómez G, Milara-Ibáñez C, Sánchez M, Pachón J, Cordero E. Unexpected severity of cases of influenza B infection in patients that required hospitalization during the first postpandemic wave. J Infect. 2012;65:423–430.

    Article  PubMed  Google Scholar 

  11. Heikkinen T, Ikonen N, Ziegler T. Impact of influenza B lineage-level mismatch between trivalent seasonal influenza vaccines and circulating viruses, 1999-2012. Clin Infect Dis. 2014;59:1519–1524.

    Article  PubMed  Google Scholar 

  12. Hong KW, Cheong HJ, Song JY, Noh JY, Yang TU, Kim WJ. Clinical Manifestations of Influenza A and B in Children and Adults in a Tertiary Hospital in Korea: 2011-2012 Season. Jpn J Infect Dis. 2014 Nov 25 https://www.jstage.jst.go.jp/article/yoken/advpub/0/advpub_JJID.2013.466/_pdf

    Google Scholar 

  13. Jain VK, Rivera L, Zaman K, Espos RA Jr, Sirivichayakul C, Quiambao BP, Rivera-Medina DM, Kerdpanich P, Ceyhan M, Dinleyici EC, Cravioto A, Yunus M, Chanthavanich P, Limkittikul K, Kurugol Z, Alhan E, Caplanusi A, Durviaux S, Boutet P, Ofori-Anyinam O, Chandrasekaran V, Dbaibo G, Innis BL. Vaccine for prevention of mild and moderate-to severe influenza in children. N Engl J Med. 2013;369:2481–2491.

    Article  CAS  PubMed  Google Scholar 

  14. Kieninger D, Sheldon E, Lin WY, Yu CJ, Bayas JM, Gabor JJ, Esen M, Fernandez Roure JL, Narejos Perez S, Alvarez Sanchez C, Feng Y, Claeys C, Peeters M, Innis BL, Jain V. Immunogenicity, reactogenicity and safety of an inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine: a phase III, randomized trial in adults aged =18 years. BMC Infect Dis. 2013;13:343.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Langley JM, Carmona Martinez A, Chatterjee A, Halperin SA, McNeil S, Reisinger KS, Aggarwal N, Huang LM, Peng CT, Garcia-Sicilia J, Salamanca de la Cueva I, Cabañas F, Treviño-Garza C, Rodríguez-Weber MA, de la O M, Chandrasekaran V, Dewé W, Liu A, Innis BL, Jain VK. Immunogenicity and safety of an inactivated quadrivalent influenza vaccine candidate: a phase III randomized controlled trial in children. J Infect Dis. 2013;208:544–553.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Pépin S, Donazzolo Y, Jambrecina A, Salamand C, Saville M. Safety and immunogenicity of a quadrivalent inactivated influenza vaccine in adults. Vaccine. 2013;31:5572–5578.

    Article  PubMed  Google Scholar 

  17. Robert Koch-Institut. Arbeitsgemeinschaft Influenza. Saisonberichte (https://influenza.rki.de/Saisonbericht.aspx)

  18. Rodriguez Weber MA, Claeys C, Doniz CA, Feng Y, Innis BL, Jain VK, Peeters M. Immunogenicity and safety of inactivated quadrivalent and trivalent influenza vaccines in children 18-47 months of age. Pediatr Infect Dis J. 2014;33:1262–1269.

    Article  PubMed  Google Scholar 

  19. Sauerbrei A, Langenhan T, Brandstadt A, Schmidt-Ott R, Krumbholz A, Girschick H, Huppertz H, Kaiser P, Liese J, Streng A, Niehues T, Peters J, Sauerbrey A, Schroten H, Tenenbaum T, Wirth S, Wutzler P. Prevalence of antibodies against influenza A and B viruses in children in Germany, 2008 to 2010. Euro Surveill. 2014 Feb 6;19(5).

    Google Scholar 

  20. Su S, Chaves SS, Perez A, D’Mello T, Kirley PD, Yousey-Hindes K, Farley MM, Harris M, Sharangpani R, Lynfield R, Morin C, Hancock EB, Zansky S, Hollick GE, Fowler B, McDonald-Hamm C, Thomas A, Horan V, Lindegren ML, Schaffner W, Price A, Bandyopadhyay A, Fry AM. Comparing clinical characteristics between hospitalized adults with laboratory-confirmed influenza A and B virus infection. Clin Infect Dis. 2014;59:252–255.

    Article  CAS  PubMed  Google Scholar 

  21. Tinoco JC, Pavia-Ruz N, Cruz-Valdez A, Aranza Doniz C, Chandrasekaran V, Dewé W, Liu A, Innis BL, Jain VK. Immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged =18 years: a phase III, randomized trial. Vaccine. 2014;32:1480–1487.

    Article  CAS  PubMed  Google Scholar 

  22. Wong KK, Jain S, Blanton L, Dhara R, Brammer L, Fry AM, Finelli L. Influenza-associated pediatric deaths in the United States, 2004-2012. Pediatrics. 2013;132:796–804.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Universitätsklinikum Jena, Institut für Virologie und Antivirale Therapie, Hans-Knöll-Str. 2, D-07745, Jena, Deutschland

    Peter Wutzler

  2. Taufkirchen, Deutschland

    Brigitte Dietz (Kinder- und Jugendarztpraxis)

  3. Katholisches Klinikum Mainz, St. Hildegardis-Krankenhaus, Bremen, Deutschland

    Roland Hardt

  4. Bremen, Deutschland

    Lutz Hoins (Praxis für Frauenheilkunde und Geburtshilfe)

  5. HSK Dr.-Hans-Schmidt-Kliniken, Wiesbaden, Deutschland

    Markus Knuf

  6. Münster, Deutschland

    Klaus Wahle (Praxis für Innere und Allgemeinmedizin)

Authors
  1. Peter Wutzler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brigitte Dietz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Roland Hardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lutz Hoins
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Markus Knuf
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Klaus Wahle
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter Wutzler.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wutzler, P., Dietz, B., Hardt, R. et al. Vierfach gegen Grippe: bald Standard?. MMW - Fortschritte der Medizin 157, 60–65 (2015). https://doi.org/10.1007/s15006-015-3480-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-015-3480-9

Keywords

Search

Navigation