Skip to main content
SpringerLink
Log in

Langzeitüberleben von Darmkrebspatienten dank multimodaler Therapieoptionen

Lebermetastasen: Heute kein Todesurteil mehr!

Multimodal treatment of colorectal liver metastases

  • FORTBILDUNG_SCHWERPUNKT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

Bis vor einigen Jahren galten Lebermetastasen als Todesurteil. Durch Fortschritte in der Leberchirurgie und durch hoch effektive chemotherapeutische Regime können die Patienten aber heute lange Zeit überleben. Am besten ist dies bei kolorektalen Karzinomen belegt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Schlesinger-Raab, A., et al. Versorgungsforschung: Kolorektales Karzinom. Evaluation der Versorgung von Darmkrebspatienten im Einzugsgebiet des Tumorregisters München (TRM) auf der Basis der aktuellen S3-Leitlinie 2012.

  2. Leitlinienprogramm Onkologie (Deutsche Krebsgesellschaft, D.K., AWMF) S3-Leitlinie Kolorektales Karzinom, Langversion 1.1, AWMF Registrierungsnummer: 021-007OL. 2014.

  3. Jones, R.P., et al., Effect of specialist decision-making on treatment strategies for colorectal liver metastases. Br J Surg, 2012. 99(9): p. 1263–9.

    Article  CAS  PubMed  Google Scholar 

  4. Folprecht, G., et al., Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol, 2010. 11(1): p. 38–47.

    Article  CAS  PubMed  Google Scholar 

  5. Heinemann, V., et al., FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol, 2014. 15(10): p. 1065–75.

    Article  CAS  PubMed  Google Scholar 

  6. Loupakis, F., et al., Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer. N Engl J Med, 2014. 371(17): p. 1609–18.

    Article  PubMed  Google Scholar 

  7. Schnitzbauer, A.A., et al., Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg, 2012. 255(3): p. 405–14.

    Article  PubMed  Google Scholar 

  8. Majno, P., et al., Anatomy of the liver: an outline with three levels of complexity—a further step towards tailored territorial liver resections. J Hepatol, 2014. 60(3): p. 654–62.

    Article  PubMed  Google Scholar 

  9. Adam, R., et al., Two-stage hepatectomy: A planned strategy to treat irresectable liver tumors. Ann Surg, 2000. 232(6): p. 777–85.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  10. Rahbari, N.N., et al., Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS—a randomised controlled multicentre trial (ISRCTN30964555). BMC Cancer, 2012. 12: p. 142.

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Allgemeine, Viszeral-, Transplantations-, Gefäß- und Thoraxchirurgie, Klinikum der Universität München, Marchioninistr. 15, D-81377, München, Deutschland

    Markus Albertsmeier,  Markus Guba,  Jens Werner &  Martin Angele

  2. Medizinische Klinik und Poliklinik III, Klinikum der Universität München, München, Deutschland

    Sebastian Stintzing

Authors
  1. Markus Albertsmeier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sebastian Stintzing
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Markus Guba
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jens Werner
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Martin Angele
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Markus Albertsmeier.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Albertsmeier, M., Stintzing, S., Guba, M. et al. Lebermetastasen: Heute kein Todesurteil mehr!. MMW - Fortschritte der Medizin 157, 47–50 (2015). https://doi.org/10.1007/s15006-015-3419-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-015-3419-1

Keywords

Search

Navigation