Zusammenfassung
Die Osteoporose ist eine der häufigsten Erkrankungen der Frau in der Postmenopause. Liegt die Häufigkeit bei 50-Jährigen nur bei 12%, so hat bereits die Hälfte aller über 74-Jährigen eine Osteoporose. Orientieren Sie sich auf den folgenden Seiten, um rechtzeitig eine adäquate Therapie einleiten zu können.
Literatur
Pfeilschifter J. 2006 DVO-guideline for prevention, diagnosis, and therapy of osteoporosis for women after menopause, for men after age 60 executive summary guidelines. Exp Clin Endocrinol Diabetes. 2006;114:611–22
Hadji P et al. The epidemiology of osteoporosis-Bone Evaluation Study (BEST): an analysis of routine health insurance data. Dtsch Arztebl Int. 2013;110:52–7
Reginster JY. Antifracture efficacy of currently available therapies for postmenopausal osteoporosis. Drugs. 2011;7:65–78
Seeman E et al. Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age. Bone. 2010; 46:1038–42
Misra M, Klibanski A. Anorexia nervosa and bone. J Endocrinol. 2014;221:163–76
Wisser J et al. Changes in bone density and metabolism in pregnancy. Acta Obstet Gynecol Scand. 2005;84:349–54
Lanham SA et al. Intrauterine programming of bone. Part 1: Alteration of the osteogenic environment. Osteoporos Int. 2008;19:147–56
Lanham SA et al. Intrauterine programming of bone. Part 2: Alteration of skeletal structure. Osteoporos Int 2008;19:157–67.
Kovacs CS. Kalzium and bone metabolism during pregnancy and lactation. J Mammary Gland Biol Neoplasia. 2005;10:105–18
Wuertz C et al. Cross-sectional study of factors that influence the 25-hydroxyvitamin D status in pregnant women and in cord blood in Germany. Br J Nutr. 2013;110:1895–902
Wagner CL et al. Health characteristics and outcomes of two randomized vitamin D supplementation trials during pregnancy: a combined analysis. J Steroid Biochem Mol Biol. 2013;136:313–20
Steib-Furno S et al. Pregnancy-related hip diseases: incidence and diagnoses. Joint Bone Spine. 2007;74:3738
Hellmeyer L et al. The use of i. v. bisphosphonate in pregnancy-associated osteoporosis—case study. Exp Clin Endocrinol Diabetes. 2007;115:139–42
Hellmeyer L et al. Quantitative ultrasonometry of the phalanges during pregnancy: a longitudinal study. Climacteric. 2006;9:446–51
Hadji P. Aromatasehemmer-induzierte Osteoporose. Möglichkeiten der Diagnostik, Prävention und Therapie. Osteologie. 2010;19:144–8
Eastell R. Aromatase inhibitors and bone. J Steroid Biochem Mol Biol. 2007;106:157–61
Rizzoli R et al. Guidance for the prevention of bone loss and fractures in postmenopausal women treated with aromatase inhibitors for breast cancer: an ESCEO position paper. Osteoporos Int;2012;23:2567–76
Podsiadlo D, Richardson S. The timed „Up & Go“: a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc. 1991;39:142–8
Guralnik JM et al. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med. 1995;32:556–61
Krege JH et al. A simple method for determining the probability a new vertebral fracture is present in postmenopausal women with osteoporosis. Osteoporos Int. 2006;17: 379–86
O’Connell TX, Horita TJ, Kasravi B. Understanding and interpreting serum protein electrophoresis. Am Fam Physician. 2005;71: 105–12
Michaelsson K et al. Long term Kalzium intake and rates of all cause and cardiovascular mortality: community based prospective longitudinal cohort study. BMJ. 2013;346:228
Reid IR, Bristow SM, Bolland MJ. Cardiovascular Complications of Kalzium Supplements. J Cell Biochem. 2013;2014:25028
Holick MF, Matsuoka LY, Wortsman J. Age, vitamin D, and solar ultraviolet. Lancet. 1989;2:1104–5
Tsai KS et al. Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis. J Clin Invest. 1984;73:1668–72
Bischoff-Ferrari HA et al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005;293:2257–64
Ralston SH et al. Randomized trial of alendronate plus vitamin D3 versus standard care in osteoporotic postmenopausal women with vitamin D insufficiency. Calcif Tissue Int. 2011;88:485–94
Carmel AS et al. The 25(OH)D level needed to maintain a favorable bisphosphonate response is >/=33 ng/ml. Osteoporos Int. 2012;23:2479–87
Holick MF et al. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. J Clin Endocrinol Metab. 2012;97:1153–8
Holick MF et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911–30
Kanis JA et al. Bazedoxifene reduces vertebral and clinical fractures in postmenopausal women at high risk assessed with FRAX. Bone. 2009;44:1049–54
Reid IR. Short-term and long-term effects of osteoporosis therapies. Nat Rev Endocrinol. 2015;11:418–28
Moreira LD et al. Physical exercise and osteoporosis: effects of different types of exercises on bone and physical function of postmenopausal women. Arq Bras Endocrinol Metabol. 2014;58:514–22
Author information
Authors and Affiliations
Corresponding author
Additional information
This article is part of a supplement not sponsored by the industry.
Interessenkonflikt
Die Autorin erklärt, dass sie sich bei der Erstellung des Beitrages von keinen wirtschaftlichen Interessen leiten ließ. Sie legt folgende potenzielle Interessenkonflikte offen: Vortragshonorare: MSD, Lilly, Amgen, GSK, Servier; Advisory Board: MSD, Lilly, Amgen, Servier.
Der Verlag erklärt, dass die inhaltliche Qualität des Beitrags von zwei unabhängigen Gutachtern geprüft wurde. Werbung in dieser Zeitschriftenausgabe hat keinen Bezug zur CME-Fortbildung. Der Verlag garantiert, dass die CME-Fortbildung sowie die CME-Fragen frei sind von werblichen Aussagen und keinerlei Produktempfehlungen enthalten. Dies gilt insbesondere für Präparate, die zur Therapie des dargestellten Krankheitsbildes geeignet sind.
Rights and permissions
About this article
Cite this article
Siggelkow, H. Die Osteoporose der Frau. MMW - Fortschritte der Medizin 157 (Suppl 3), 73–80 (2015). https://doi.org/10.1007/s15006-015-3301-1
Published:
Issue Date:
DOI: https://doi.org/10.1007/s15006-015-3301-1