Skip to main content
SpringerLink
Log in

HPV-Infektion: Neuer Risikofaktor für Mund-Rachen-Karzinome

Wandel in der Pathogenese

  • FORTBILDUNG_SCHWERPUNKT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

Früher waren vor allem Tabakrauch und Alkoholkonsum Risikofaktoren für Kopf-Hals-Karzinome. Heute gewinnt dagegen die Infektion mit Humanen Papillomaviren (HPV) an Bedeutung. Von dieser neuen Tumorentität sind vor allem Männer mit häufig wechselnden Sexualpartnern betroffen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global Caner Statistics. CA Cancer J Clin, 2011; 61: 69–90.

    Article  PubMed  Google Scholar 

  2. Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends form human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol, 2008; 26: 612–619.

    Article  PubMed  Google Scholar 

  3. Syrjanen KJ, Pyrhonen S, Syrjanen SM, Lamberg MA. Immunohistochemical demonstration of human papilloma virus (HPV) antigens in oral squamous cell lesions. Br J Oral Surg, 1983; 21: 147–153.

    Article  CAS  PubMed  Google Scholar 

  4. Kreimer AR, Clifford GM, Boyle P, Franceschi S. Human papillomavirus in head and neck squamous cell carcinoma worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev, 2005; 14: 467–475.

    Article  CAS  PubMed  Google Scholar 

  5. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Zahurak ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst, 2000; 92: 709–720.

    Article  CAS  PubMed  Google Scholar 

  6. Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Kolligs J, Jungehuelsing M, Eckel HE, Dienes HP, Pfister HJ, Fuchs PG. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer, 2001; 92: 2875–2884.

    Article  CAS  PubMed  Google Scholar 

  7. Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Jiang B, Goodman MT, Sibug-Saber M, Cozen W, Liu L, Lynch CF, Wentzensen N, Jordan RC, Altekruse S, Anderson WF, Rosenberg PS, Gillison ML. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol, 2011; 29: 4294–4301.

    Article  PubMed  Google Scholar 

  8. Hammarstedt L, Lindquist D, Dahlstrand H, Romanitan M, Dahlgren LO, Joneberg J, Creson N, Lindholm J, Ye W, Dalianis T, Munck- Wikland E. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer, 2006; 119: 2620–2623.

    Article  CAS  PubMed  Google Scholar 

  9. Näsman A, Attner P, Hammarstedt L, Du J, Eriksson M, Giraud G, Ahrlund-Richter S, Marklund L, Romanitan M, Lindquist D, Ramqvist T, Lindholm J, Spar'n P, Ye W, Dahlstrand H, Munck-Wikland E, Dalianis T. Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma? Int J Cancer, 2009; 125: 362–366.

    Article  PubMed  Google Scholar 

  10. Attner P, Du J, Näsman A, Hammarstedt L, Ramqvist T, Lindholm J, Marklund L, Dalianis T, Munck-Wikland E. The role of human papillomavirus in the increased incidence of base of tongue cancer. Int J Cancer, 2010; 126: 2879–2884.

    CAS  PubMed  Google Scholar 

  11. Auluck A, Hslop G, Bajdik C, Poh C, Zhang L, Rosin M. Trends in oropharyngeal and oral cavity cancer incidences of human papillomavirus (HPV)-related and HPV-unrelated sites in a multicultural population: the British Columbia experience. Cancer, 2010; 116: 2635–2644.

    PubMed  Google Scholar 

  12. Hocking JS, Stein A, Conway EL, Regan D, Grulich A, Law M, Brotherton JM. Head and neck cancer in Australia between 1982 and 2005 show increasing incidence of potentially HPV-associated oropharyngeal cancers. Br J Cancer, 2011; 104: 886–891.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Marur S, D'souza G, Westra WH, Forastiere AA. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol, 2010; 11: 781–789.

    Article  PubMed  Google Scholar 

  14. D'souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, Westra WH, Gillison ML. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med, 2007; 356: 1944–1956.

    Article  PubMed  Google Scholar 

  15. Herbenick D, Reece M, Schick V, Sanders SA, Dodge B, Fortenberry JD. Sexual behavior in the United States: results from a national probability sample of men and women ages 14-94. J Sex Med, 2010; 7: S255–S265.

    Article  Google Scholar 

  16. Bajos N, Bozon M, Beltzer N, Laborde C, Andro A, Ferrand M, Goulet V, Laporte A, Le Van C, Leridon H, Levinson S, Razafin ndratsima N, Toulemon L, Warszawski J, Wellings K. Changes in sexual behaviours: from secular trends to public health policies. AIDS, 2010; 24: 1185–1191.

    Article  PubMed  Google Scholar 

  17. Gillison ML, Broutian T, Pickard RK, Tong Z, Xiao W, Kahle L, Graubard BI, Chaturvedi AK. Prevalence of oral HPV infection in the United States, 2009 - 2010. JAMA, 2012; 307: 693–703.

    Article  CAS  PubMed  Google Scholar 

  18. Schiffman M, Wentzensen N, Wacholder S, Kinney W, Gage JC, Castle PE. Human papillomavirus testing in the prevention of cervical cancer. J Natl Cancer Inst, 2011; 103: 368–383.

    Article  PubMed  Google Scholar 

  19. D'souza G, Gross ND, Pai SI, Haddad RI, Gillison ML, Posner MR. Oral HPV infection in HPV-positive oropharyngeal cancer cases and their spouses. J Clin Oncol, 2013; 31: abstr CRA6031.

    Google Scholar 

  20. Kim L, King T, Agulnik M. Head and neck cancer: changing epidemiology and public health implications. Oncology (Williston Park), 2010. 24: 915–924.

    Google Scholar 

  21. Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer, 1953; 6: 963–968.

    Article  CAS  PubMed  Google Scholar 

  22. Assmann G, Sotlar K. HPV-assoziierte Plattenepithelkarzinogenese. Der Pathologe, 2011; 31: 391–398.

    Article  Google Scholar 

  23. Zandberg DP, bhargava R, Badin S, Cullen KJ. The role of human papillomavirus in nongenital cancers. CA Cancer J Clin, 2013; 63: 57–81.

    Article  PubMed  Google Scholar 

  24. Zengel P, Assmann G, Mollenhauer M, Jung A, Sotlar K, Kirchber T, Ihrler S. Cancer of unknown primary originating from oropharyngeal carcinomas are strongly correlated to HPV positivity. Virchows Arch, 2012; 461: 283–290.

    Article  PubMed  Google Scholar 

  25. Vent J, Haidle B, Wedemeyer I, Huebbers C, Siefer C, Semrau R, Preuss SF, Klussmann J. P16 expression in carcinoma of unknown primary: diagnostic indicator and prognostic marker. Head Neck, 2013; 35: 1521–1526.

    Article  PubMed  Google Scholar 

  26. Ang KK, Sturgis EM. Human papillomavirus as a marker of the natural history and response to therapy of head and neck squamous cell carcinoma. Semin Radiat Oncol, 2012; 22: 128–142.

    Article  PubMed  Google Scholar 

  27. Gillespie MB, Rubinchik S, Hoel B, Sutkowski N. Human papillomavirus and oropharyngeal cancer: what you need to know in 2009. Curr Treat Options Oncol, 2009; 10: 296–307.

    Article  PubMed  Google Scholar 

  28. Chaturvedi AK. Epidemiology and clinical aspects of HPV in head and neck cancers. Head Neck Pathol, 2012; 6: S16–S24.

    Article  PubMed  Google Scholar 

  29. Nguyen NP, Chi A, Nguyen LM, Ly BH, Karlsson U, Vinh-Hung V. Human papillomavirusassociated oropharyngeal cancer: a new clinical entity. QJM, 2010; 103: 229–236.

    Article  CAS  PubMed  Google Scholar 

  30. Wiest T, Schwarz E, Enders C, Flechtenmacher C, Bosch FX. Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene, 2002; 21: 1510–1517.

    Article  CAS  PubMed  Google Scholar 

  31. Maxwell JH, Kumar B, Feng FY, Worden FP, Lee JS, Eisbruch A, Wolf GT, Prince ME, Moyer JS, Teknos TN, Chepeha DB, McHugh JB, Urba SG, Stoerker J, Walline HM, Kurnit DM, Cordell KG, Davis SJ, Ward PD, Bradford CR, Carey TE. Tobacco use in human papillomavirus- positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clin Cancer Res, 2010; 16: 1226–1235.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  32. Fischer CA, Zlobec I, Green E, Probst S, Storck C, Lugli A, Tornillo L, Wolfensberger M, Terracciano LM. Is the improved prognosis of p16 positive oropharyngeal squamous cell carcinoma dependent of the treatment modality? Int J Cancer, 2010; 126: 1256–1262.

    CAS  PubMed  Google Scholar 

  33. Haughey BH, Sinha P. Prognostic factors and survival unique to surgically treated p16+ oropharyngeal cancer. Laryngoscope, 2012; 122: S13–S33.

    Article  PubMed  Google Scholar 

  34. Huang SH, Perez-Ordonez B, Weinreb I, Hope A, Massey C, Waldron JN, Kim J, Bayley AJ, Cummings B, Cho BC, Ringash J, Dawson LA, Siu LL, Chen E, Irish J, Gullane P, Hui A, Liu FF, Shen X, Xu W, O'sullivan B. Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPVrelated oropharyngeal cancer. Oral Oncol, 2013; 49: 79–85.

    Article  PubMed  Google Scholar 

  35. O'sullivan B, Huang SH, Siu LL, Waldron J, Zhao H, Perez-Ordonez B, Weinreb I, Kim J, Ringash J, Bayley A, Dawson LA, Hope A, Cho J, Irish J, Gilbert R, Gullane P, Hui A, Liu FF, Chen E, Xu W. Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. J Clin Oncol, 2013; 31: 543–550.

    Article  PubMed  Google Scholar 

  36. Rowe Price K, Okuno SH, Garcia JJ, Molina JR, Olsen KD, Kasperbauer JC, Price DL, Garces YI, Ma D, Neben-Wittich MA, Shull AE, Foote RL, Moore EJ. Survival in patients with HPVpositive oropharynx squamous cell carcinoma with distant metastases. J Clin Oncol, 2013; 31: abstr 6095.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Klinikum Großhadern, Marchioninistr. 15, D-81366, München, Deutschland

    Philipp Baumeister &  Ulrich Harréus

Authors
  1. Philipp Baumeister
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ulrich Harréus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Philipp Baumeister.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baumeister, P., Harréus, U. HPV-Infektion: Neuer Risikofaktor für Mund-Rachen-Karzinome. MMW - Fortschritte der Medizin 156, 45–48 (2014). https://doi.org/10.1007/s15006-014-2660-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-014-2660-3

Keywords - Oropharyngeal squamous cell cancer change in pathogenesis

Search

Navigation