Skip to main content
Log in

Die Saison hat schon begonnen

Frühsommer-Meningoenzephalitis

  • FORTBILDUNG_ÜBERSICHT
  • Published:
MMW - Fortschritte der Medizin Aims and scope

Zusammenfassung

Die beiden häufigsten durch Zecken übertragenen neurologischen Erkrankungen in Europa sind die Neuroborreliose (neurologische Manifestation der Lyme-Borreliose) und die Frühsommer-Meningoenzephalitis (FSME). Beiden Erkrankungen gemeinsam sind der Übertragungsmodus und das Auslösen neurologischer Symptome. Häufiger als die Neuroborreliose hinterlässt die FSME nach der akuten Erkrankung jedoch lang anhaltende neurologische Defizite.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. Heinz FX, Mandl CW. The molecular biology of tick-borne encephalitis virus. Review article. APMIS 1993;101:735–745

    Article  CAS  PubMed  Google Scholar 

  2. Mandl CW, Heinz FX, Stockl E et al. Genome sequence of tick-borne encephalitis virus (Western subtype) and comparative analysis of nonstructural proteins with other flaviviruses. Virology 1989;173:291–301

    Article  CAS  PubMed  Google Scholar 

  3. Chambers TJ, Hahn CS, Galler R et al. Flavivirus genome organization, expression, and replication. Annu Rev Microbiol 1990;44:649–688

    Article  CAS  PubMed  Google Scholar 

  4. Holzmann H, Vorobyova MS, Ladyzhenskaya IP et al. Molecular epidemiology of tick-borne encephalitis virus: cross-protection between European and Far Eastern subtypes. Vaccine 1992;10:345–349

    Article  CAS  PubMed  Google Scholar 

  5. Chiba N, Iwasaki T, Mizutani T et al. Pathogenicity of tick-borne encephalitis virus isolated in Hokkaido, Japan in mouse model. Vaccine 1999;17:779–787

    Article  CAS  PubMed  Google Scholar 

  6. Leonova GN, Ternovoi VA, Pavlenko EV et al. Evaluation of vaccine Encepur Adult for induction of human neutralizing antibodies against recent Far Eastern subtype strains of tick-borne encephalitis virus. Vaccine 2007;25:895–901

    Article  CAS  PubMed  Google Scholar 

  7. WHO. Vaccines against tick-borne encephalitis: WHO position paper. Wkly Epidemiol Rec 2011;86:241-256

    Google Scholar 

  8. Holzmann H, Aberle SW, Stiasny K et al. Tickborne encephalitis from eating goat cheese in a mountain region of Austria. Emerg Infect Dis 2009;15:1671–1673

    Article  PubMed  Google Scholar 

  9. Poponnikova TV. Specific clinical and epidemiological features of tick-borne encephalitis in Western Siberia. Int J Med Microbiol 2006;296 Suppl 40:59–62

    Article  PubMed  Google Scholar 

  10. Barrett, P. N., Dorner, F., Ehrlich, H. J., and Plotkin, SA. Tick-borne encephalitis virus vaccine. In: Plotkin, SA and Orenstein, WA. Vaccines. Elsevier Inc USA, 20

  11. Dobler G, Gniel D, Petermann R et al. Epidemiology and distribution of tick-borne encephalitis. Wien Med Wochenschr 2012;162:230–238

    Article  PubMed  Google Scholar 

  12. Kaiser R. The clinical and epidemiological profile of tick-borne encephalitis in southern Germany 1994–98: a prospective study of 656 patients. Brain 1999;122( Pt 11):2067–2078

    Google Scholar 

  13. Nuttall PA. Pathogen-tick-host interactions: Borrelia burgdorferi and TBE virus. Zentralbl Bakteriol 1999;289:492–505

    Article  CAS  PubMed  Google Scholar 

  14. Labuda M, Austyn JM, Zuffova E et al. Importance of localized skin infection in tick-borne encephalitis virus transmission. Virology 1996;219:357–366

    Article  CAS  PubMed  Google Scholar 

  15. Ruzek D, Dobler G, Mantke OD. Tick-borne encephalitis: pathogenesis and clinical implications. Travel Med Infect Dis 2010;8:223–232

    Article  PubMed  Google Scholar 

  16. Khor CC, Hibberd ML. Host-pathogen interactions revealed by human genome-wide surveys. Trends Genet 2012;28:233–243

    Article  CAS  PubMed  Google Scholar 

  17. Davila S, Wright VJ, Khor CC et al. Genomewide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet 2010;42:772–776

    Article  CAS  PubMed  Google Scholar 

  18. Gassmann C, Bauer G. Avidity determination of IgG directed against tick-borne encephalitis virus improves detection of current infections. J Med Virol 1997;51:242–251

    Article  CAS  PubMed  Google Scholar 

  19. Kaiser R, Holzmann H. Laboratory findings in tick-borne encephalitis-correlation with clinical outcome. Infection 2000;28:78–84

    Article  CAS  PubMed  Google Scholar 

  20. Schultze D, Dollenmaier G, Rohner A et al. Benefit of detecting tick-borne encephalitis viremia in the first phase of illness. J Clin Virol 2007;38:172–175

    Article  PubMed  Google Scholar 

  21. Puchhammer-Stockl E, Kunz C, Mandl CW et al. Identification of tick-borne encephalitis virus ribonucleic acid in tick suspensions and in clinical specimens by a reverse transcription-nested polymerase chain reaction assay. Clin Diagn Virol 1995;4:321–326

    Article  CAS  PubMed  Google Scholar 

  22. Poschl P, Kleiter I, Grubwinkler S et al. [Severe tick-borne encephalomyelitis with lack of cerebrospinal fluid pleocytosis]. Fortschr Neurol Psychiatr 2009;77:591–593

    Article  CAS  PubMed  Google Scholar 

  23. Pfefferkorn T, Feddersen B, Schulte-Altedorneburg G et al. Tick-borne encephalitis with polyradiculitis documented by MRI. Neurology 2007;68:1232–1233

    Article  CAS  PubMed  Google Scholar 

  24. Marjelund S, Tikkakoski T, Tuisku S et al. Magnetic resonance imaging findings and outcome in severe tick-borne encephalitis. Report of four cases and review of the literature. Acta Radiol 2004;45:88–94

    Article  CAS  PubMed  Google Scholar 

  25. Stich O, Reinhard M, Rauer S. MRI scans of cervical cord provide evidence of anterior horn lesion in a patient with tick-borne encephalomyeloradiculitis. Eur J Neurol 2007;14:e5–e6

    Article  CAS  PubMed  Google Scholar 

  26. Bender A, Schulte-Altedorneburg G, Walther EU et al. Severe tick borne encephalitis with simultaneous brain stem, bithalamic, and spinal cord involvement documented by MRI. J Neurol Neurosurg Psychiatry 2005;76:135–137

    Article  CAS  PubMed  Google Scholar 

  27. Kaiser R, Vollmer H, Schmidtke K et al. [Followup and prognosis of early summer meningoencephalitis]. Nervenarzt 1997;68:324–330

    Article  CAS  PubMed  Google Scholar 

  28. Lammli B, Muller A, Ballmer PE. [Late sequelae of early summer meningoencephalitis]. Schweiz Med Wochenschr 2000;130:909–915

    CAS  PubMed  Google Scholar 

  29. Gunther G, Haglund M, Lindquist L et al. Tick-borne encephalitis in Sweden in relation to aseptic meningo-encephalitis of other etiology: a prospective study of clinical course and outcome. J Neurol 1997;244:230–238

    Article  CAS  PubMed  Google Scholar 

  30. Schwanda M, Oertli S, Frauchiger B et al. [Tick-borne meningoencephalitis in Thurgau Canton: a clinical and epidiomological analysis]. Schweiz Med Wochenschr 2000;130:1447–1455

    CAS  PubMed  Google Scholar 

  31. Haglund M, Forsgren M, Lindh G et al. A 10- year follow-up study of tick-borne encephalitis in the Stockholm area and a review of the literature: need for a vaccination strategy. Scand J Infect Dis 1996;28:217–224

    Article  CAS  PubMed  Google Scholar 

  32. Mickiene A, Laiskonis A, Gunther G et al. Tickborne encephalitis in an area of high endemicity in Lithuania: disease severity and long-term prognosis. Clin Infect Dis 2002;35:650–658

    Article  PubMed  Google Scholar 

  33. Laursen K, Knudsen JD. Tick-borne encephalitis: a retrospective study of clinical cases in Bornholm, Denmark. Scand J Infect Dis 2003;35:354–357

    Article  PubMed  Google Scholar 

  34. Gustaw-Rothenberg K. Cognitive impairment after tick-borne encephalitis. Dement Geriatr Cogn Disord 2008;26:165–168

    Article  PubMed  Google Scholar 

  35. Kaiser R. [Long-term prognosis of patients with primary myelitic manifestation of tickborne encephalitis: A trend analysis covering 10 years]. Nervenarzt 2011

  36. Lesnicar G, Poljak M, Seme K et al. Pediatric tick-borne encephalitis in 371 cases from an endemic region in Slovenia, 1959 to 2000. Pediatr Infect Dis J 2003;22:612–617

    Article  PubMed  Google Scholar 

  37. Cizman M, Rakar R, Zakotnik B et al. Severe forms of tick-borne encephalitis in children. Wien Klin Wochenschr 1999;111:484–487

    CAS  PubMed  Google Scholar 

  38. Rakar, R. Klopni Meningoencefalitis pri otroku. In: Rakar, R. Proceedings. Celje: Bedjanicev Simpozij V Zdraviliscu Dobrna, 1993.

  39. Harasek G. [Tick-borne encephalitis in children (author's transl)]. Dtsch Med Wochenschr 1974;99:1965–1970

    Article  CAS  PubMed  Google Scholar 

  40. Messner, H. Pediatric Problems of TBE. In: Kunz, C. Tick-Borne Encephalitis. Wien: Facultas- Verlag,1981:25-27

  41. Helwig H, Forster J, Neumann-Haefelin D et al. Die klinische Bedeutung von FSME-Virusinfektionen im Kindesalter. Paediat Prax 1983;28:75–82

    Google Scholar 

  42. Roggendorf M, Goldhofer E, Heinz FX et al. [Epidemiology of tick-borne encephalitis in Southern Germany (author's transl)]. MMW Munch Med Wochenschr 1981;123:1407–1411

    CAS  PubMed  Google Scholar 

  43. Grubbauer HM, Dornbusch HJ, Spork D et al. Tick-borne encephalitis in a 3-month-old child. Eur J Pediatr 1992;151:743–744

    Article  CAS  PubMed  Google Scholar 

  44. Kluger G, Schöttler A, Waldvogel A et al. Tickborne encephalitis despite specific immunoglobulin prophylaxis. Lancet 1995;346:1502.

    Article  CAS  PubMed  Google Scholar 

  45. Waldvogel K, Bossart W, Huisman T et al. Severe tick-borne encephalitis following passive immunization. Eur J Pediatr 1996;155:775–779

    Article  CAS  PubMed  Google Scholar 

  46. Lindquist L. Tick-borne encephalitis (TBE) in childhood. Acta Paediatr 2008;97:532–534

    Article  PubMed  Google Scholar 

  47. Fowler A, Forsman L, Eriksson M et al. Tick- Borne Encephalitis Carries a High Risk of Incomplete Recovery in Children. J Pediatr 2013.

  48. Pazdiora P, Struncova V, Svecova M. Tick-borne encephalitis in children and adolescents in the Czech Republic between 1960 and 2007. World J Pediatr 2012;8:363–366

    Article  PubMed  Google Scholar 

  49. Rostasy K. Tick-borne encephalitis in children. Wien Med Wochenschr 2012;162:244–247

    Article  PubMed  Google Scholar 

  50. Plentz A, Jilg W, Schwarz TF et al. Long-term persistence of tick-borne encephalitis antibodies in adults 5 years after booster vaccination with Encepur((R)) Adults. Vaccine 2009;27:853–856

    Article  CAS  PubMed  Google Scholar 

  51. Wittermann C, Petri E, Zent O. Long-term persistence of tick-borne encephalitis antibodies in children 5 years after first booster vaccination with Encepur® Children. Vaccine 2009 27:1585–1588

    Article  PubMed  Google Scholar 

  52. Broker M, Schondorf I. Are tick-borne encephalitis vaccines interchangeable? Expert Rev Vaccines 2006;5:461–466

    Article  PubMed  Google Scholar 

  53. Wittermann C, Schondorf I, Gniel D. Antibody response following administration of two paediatric tick-borne encephalitis vaccines using two different vaccination schedules. Vaccine 2009;27:1661–1666

    Article  CAS  PubMed  Google Scholar 

  54. Weinzettel R, Ertl S, Zwiauer K. [FSME monitoring: monitoring of adverse events of tickborne- encephalitis vaccines by selected paediatricians and general practitioners]. Wien Med Wochenschr 2007;157:107–110

    Article  PubMed  Google Scholar 

  55. Kaiser, R, Archelos-Garcia, J-J, Jilg, W, Rauer, S., and Sturzenegger, M. Frühsommer-Meningoenzephalitis. In: Diener, H. C. and Weimar, C. Leitlinie für Diagnostik und Therapie in der Neurologie. Stuttgart: Thieme, 2013: 554–559

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Reinhard Kaiser.

Additional information

Interessenkonflikt

Der Autor erklärt, dass er sich bei der Erstellung der Beitrags von keinerlei wirtschaftlichen Interessen leiten ließ.

Der Verlag erklärt, dass die inhaltliche Qualität des Beitrags von zwei unabhängigen Gutachtern geprüft wurde. Werbung in dieser Zeitschriftenausgabe hat keinen Bezug zur CME-Fortbildung. Der Verlag garantiert, dass die CME-Fortbildung sowie die CME-Fragen frei sind von werblichen Aussagen und keinerlei Produktempfehlungen enthalten. Dies gilt insbesondere für Präparate, die zur Therapie des dargestellten Krankheitsbildes geeignet sind.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaiser, R. Die Saison hat schon begonnen. MMW - Fortschritte der Medizin 156, 49–55 (2014). https://doi.org/10.1007/s15006-014-0003-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15006-014-0003-z

Keywords - After-care in general practice after Tick-Borne Encephalitis

Navigation